McMaster University

McMaster University

Current Students

Program Director

Peter Margetts (Program Director)
Peter Margetts

I have been the McMaster MD/PhD Program Director since 2008. I have an MD (1994) and PhD (2002) from McMaster University. I am a staff nephrologist at St. Joseph's Healthcare with an interest in dialysis and chronic kidney disease. My research interests include gene therapy, renal and peritoneal fibrosis, and evaluation of volume status in dialysis patients.

MD/PhD Related Publications:

  • MacGillivray L, Hernandez J, Maedler C, Chu D, Margetts P. Developing Clinician Scientists: The MD/PhD Program at McMaster University. McMaster University Medical Journal 2009; 6: 5-10

Students

David Bulir

David BulirAfter completing my undergraduate degree at McMaster University in the spring of 2010, I joined the McMaster MD/PhD program in September 2010. I am working on my PhD in Medical Sciences with Dr. James Mahony at St. Joseph's Healthcare Hamilton. My area of research examines the role of type III secretion, with a specific emphasis on the hydrophobic translocators, during the lifecycle of Chlamydia pneumoniae.

Publications

  • Stone, C. B., Johnson, D. L., Bulir, D. C., Gilchrist, J. D., Mahony, J. B. 2008. Characterization of the Putative Type III Secretion ATPase CdsN (Cpn0707) of Chlamydophila pneumoniae. J. Bact. 190:6580-6588.
  • Johnson, D. L, Stone, C. B., Bulir, D. C., Coombes, B.K., Mahony, J. B. A novel inhibitor of Chlamydophila pneumoniae protein kinase D (PknD) inhibits phosphorylation of CdsD and suppresses bacterial replication. 2009. BMC Microbiology. 9:218
  • Stone, CB., Bulir, D.C., Gilchrist, JD., Toor, RK., Mahony, JB. Interactions between flagellar and type III secretion proteins of Chlamydia pneumoniae. 2010. BMC Microbiology. 10:18.
  • Stone CB, Bulir D.C., Emdin CA, Pirie RM, Porfilio EA, Slootstra JW and Mahony JB (2011) Chlamydia pneumoniae CdsL regulates CdsN ATPase activity, and disruption with a peptide mimetic prevents bacterial invasion. Front. Microbio. 2:21.
  • Mahony, J., Liu, L., Pirie, R., Bulir, D.C., Stone, C. Peptide mimetics can block bacterial Type III secretion and inhibit host cell invasion. Poster Session presented at: International Congress of Chemotherapy and Infection. 26th International Congress of Chemotherapy and Infection; 2009 Jun 19-21; Toronto, ON.
Marisa Azad

Marisa AzadMarisa started the McMaster M.D./Ph.D. program in September 2010. Prior to joining the program, she obtained an Honours B.Sc. in Cellular, Molecular, and Microbial Biology at Thompson Rivers University in May 2010.

Marisa works with Dr. Gerry Wright at the Michael G. DeGroote Institute for Infectious Disease Research where her research aims to discover novel inhibitors of acetyltransferases that pathogens use to inactivate antibiotics.

Aside from science, Marisa enjoys art, philosophy, creative writing, yoga, hiking, and most of all, laughing and spending time with friends. She recently published her own art website.

Art website: http://azadma.wix.com/marisa-azad

Facebook page: https://www.facebook.com/marisa.azad.artwork

Publications

  • Azad, M. A., and Lee, C.Clostridium difficileinfection: a practical approach. 2013.Can. J. CME. 25(2):49-51.

  • McArthur, A. G., Waglechner, N., Nizam, F., Yan, A., Azad, M. A.,et al.2013. The comprehensive antibiotic resistance database. AAC. 57(7):3348-3357.

  • Azad, M. A. and Wright, D. G. 2012. Determining the mode of action of bioactive compounds. J. Bioorg. Med. Chem. 20(6):1929-1939.

  • Azad, M. A. and Wright, D. G. 2011. Determining the mode of action of bioactive compounds. J. Bioorg. Med. Chem. Accepted.
  • Azad, M. A., Huttunen-Hennelly, H. E. K., and Friedman, C. R. 2011. Bioactivity and the first transmission electron microscopy immunogold studies of short de novo-designed antimicrobial peptides. Antimicrob. Agents Chemother. 55:2137-2145.

Patents:

  • Azad, M. A. and Huttunen-Hennelly, H. E. K. (2010 Provisional Patent: Canada). MAW-1 as a novel α-helical antimicrobial peptide with an N-terminal glycine "cap."
Elizabeth Simms

E. SimmsElizabeth is studying the immunological mechanisms of allergy and immune tolerance in the laboratory of Dr. Mark Larché.  Prior to joining the MD/PhD program in 2011, she completed an M.Sc. supervised by Drs. Mark Larché and Param Nair examining the role of allergen in driving T-cell cytokine responses in asthma patients.  For her PhD thesis, she is investigating the use of peptide immunotherapy for the treatment of peanut allergy.   Clinically, Elizabeth is interested in immune-mediated pathology and the role of the immune system in health and disease.

Publications

  • Simms E, The Influence of the Intestinal Microbiome on Allergic Disease. University of Toronto Medical Journal. May 2015 [Accepted].
  • Simms E, Peptide Immunotherapy for the Treatment of Peanut Allergy. Scrub-In. 2015. 10(2):19.
  • Simms E, Rudulier C, Wattie J, Kwok WW, James E, Moldaver D, Jordana M, Larché M. Ara h 1 Peptide Immunotherapy Ameliorates Peanut-Induced Anaphylaxis. 2015. The Journal of Allergy and Clinical Immunology. 2015. 135(2):AB158.
  • Simms E, Syed I, Rudulier C, Larché M. Peptide Immunotherapy; short but long lasting? 2015. Current Treatment Options in Allergy. 2015. 2(1):64-71.
  • Simms E, Kjarsgaard M, Denis S, Hargreave F, Nair P, Larché M. Cytokine responses of peripheral blood mononuclear cells to allergen do not identify asthma or asthma phenotypes. Clinical & Experimental Allergy. 2013. 43(11):1226-1235.
  • Nair P, Ochkur S, Protheroe C, Simms E, Lee N, Lee J. The identification of eosinophilic gastroenteritis in prednisone-dependent eosinophilic bronchitis and asthma. Allergy, Asthma & Clinical Immunology. 2011. 7(4).
Sean Rasmussen
S. Rasmussen

I completed my BSc in psychology at Mount Allison University before joining the MD/PhD program at McMaster. Under the supervision of Dr. Michael Mazurek, I am investigating strategies to predict long-term treatment outcomes in response to antipsychotic medications. Recent evidence suggests that poor response to antipsychotic drugs can be predicted within the first 1-2 weeks of treatment. If physicians can identify non-responders early in treatment, then these patients could be quickly switched to another antipsychotic, minimizing the time that they are treated with ineffective medications. For this work, I have been awarded a CIHR Master’s Award and an Ontario Mental Health Foundation Studentship

Derek Chan

Derek ChanHaving just completed my undergraduate degree at McMaster, I am returning again to begin my MD/PhD studies in September 2012, conducting research in hematopoietic and leukemic stem cell biology under the supervision of Dr. Kristin Hope in the Stem Cell and Cancer Research Institute. My primary research aims are to dually investigate the molecular regulation of HSC self-renewal and identify processes that lead to leukemia transformation and progression in order to find novel treatments for such hematopoietic malignancies. In addition to conducting basic science research, my interests also broadly span the fields of paediatric oncology, global health and medical humanities.

Publications

Abstracts:

  • Chan, D.C.H., Atkinson, H., Berry, L.R., Athale, U.H. and Chan, A.K.C. Induction of endothelial von Willebrand's factor expression by precursor B lymphoblasts. XXIII Congress of the International Society of Thrombosis and Haemostasis (ISTH), 2011, Kyoto, Japan.

Articles:

  • Chan, D., Choi, W.Y., Rozenek, A. Chapter 3 – Product development partnerships, tax breaks and green intellectual property. In: Hoffman S.J., editor. Student Voices 4: Assessing Proposals for Access to Medicines Reform. Hamilton, Canada: McMaster Health Forum; 2012.
  • Chan, D., Lau, K., So, K. Advocating for global arms control: Looking beyond the arms trade treaty. In: Hoffman S.J., editor. Student Voices 5: Advocating for Global Health through Evidence, Insight and Action. Hamilton, Canada: McMaster Health Forum; 2012.
Branavan Manoranjan

B. ManoranjanMy longstanding interest in brain tumour research stems from a high school co-operative education placement during which I explored factors that contributed to the neurosurgical management and quality-of-life of brain tumour patients. Throughout my undergraduate career in McMaster University's Bachelor of Health Sciences (Honours) program I had the opportunity to expand my research interests from a clinical to basic science model by studying the role of aberrantly activated developmental signaling pathways in brain tumorigenesis. I am now excited to pursue the next stage of my training through the MD/PhD program, and thereby bridge the internationally-renowned clinical training at the Michael G. DeGroote School of Medicine with the high-impact, novel research conducted at the McMaster Stem Cell & Cancer Research Institute.

As brain tumours represent the leading cause of childhood cancer mortality, my current doctoral work in Dr. Sheila Singh's laboratory is focused on medulloblastoma (MB), the most frequent malignant pediatric brain tumour. The identification of cancer stem cells, termed brain tumour-initiating cells (BTICs), in MB has provided novel cellular targets for the study of developmental signaling pathways. My project is interested in elucidating the role of these pathways in MB BTICs. I have been fortunate enough to be awarded a CIHR Vanier Canada Graduate Scholarship for carrying out this research. My future ambition is to merge clinical and research interests in neurosurgery and neuro-oncology, respectively, through collaborative initiatives with all those involved in the treatment and care of pediatric and adult brain tumour patients as a way to bridge the gap between the laboratory bench, patient bedside, and society as a whole. In addition to conducting basic science research, my interests also relate to quality-of-life in neurosurgical patients, evidence-based neurosurgery, and surgical innovations for resource-limited regions.

PUBLISHED REFEREED PAPERS

  • Venugopal C, Hallett R, Vora P, Manoranjan B, Qazi M, McFarlane N, Mahendram S, Nolte SM, Singh M, Garg N, Bakhshinyan D, Lach B, Provias JP, Reddy K, Mury NK, Dunn SE, Doble BW, Bhatia M, Hassell J, Singh SK. Pyrvinium targets CD133 in human glioblastoma brain tumor-initiating cells. Clinical Cancer Research. (In Press).
  • Manoranjan B, Singh SK. Letter to the Editor: Temporal evolution of medulloblastoma subgroups. Journal of Neurosurgery: Pediatrics. 2015; May 29:1-2 (Epub ahead of print).
  • Manoranjan B, Garg N, Bakhshinyan D, Singh SK. The role of stem cells in pediatric central nervous system malignancies. Advances in Experimental Medicine & Biology. 2015;853:49-68.
  • Singh M, Manoranjan B, Mahendram S, McFarlane N, Venugopal C, Singh SK. Brain metastasis-initiating cells: Survival of the fittest. International Journal of Molecular Sciences. 2014;15:9117-9133.
  • Almenawer SA, Farrokhyar F, Hong C, Alhazzani W, Manoranjan B, Yarascavitch B, Armjand P, Baronia B, Murty N, Singh SK. Chronic subdural haematoma management: Systematic review and meta-analysis. Annals of Surgery. 2014:259:449-457.
  • Triscott J, Lee C, Foster C, Manoranjan B, Pambid MR, Berns R, Fotovati A, Fotovati A, Venugopal C, O’Halloran K, Narendran A, Hawkins C, Ramaswamy V, Taylor MD, Singhal A, Hukin J, Rassekh R, Northcott P, Singh SK, Dunham C, Dunn SE. Personalizing the treatment for medulloblastoma: Polo-Like Kinase 1 as a molecular target for high-risk children. Cancer Research. 2013;73:6734-6744.
  • Manoranjan B, Wang X, Hallet RM, Venugopal C, Mack SC, McFarlane N, Nolte SM, Scheinemann K, Gunnarsson T, Hassell JA, Taylor MD, Lee C, Triscott J, Dunham C, Hawkins C, Dunn SE, Singh SK. FoxG1 interacts with Bmi1 to regulate self-renewal and tumorigenicity of medulloblastoma stem cells. Stem Cells. 2013;31:1266-1277. *Identified by Stem Cells editors as top five papers published in 2014
  • Nolte SM, Venugopal C, McFarlane N, Morozova O, Hallett RM, O’Farrell E, Manoranjan B, Murty NK, Klurfan P, Kachur K, Provias JP, Hassell JA, Marro M, Singh SK. A cancer stem cell model for studying brain metastases from primary lung cancer. Journal of the National Cancer Institute. 2013;105:551-562.
  • Manoranjan B, Venugopal C, McFarlane N, Doble BW, Dunn SE, Scheinemann K, Singh SK. Medulloblastoma stem cells: Modeling tumor heterogeneity. Cancer Letters. 2013;338:23-31.
  • Venugopal C, McFarlane NM, Nolte SM, Manoranjan B, Singh SK. Processing of primary brain tumor tissue for stem cell assays and flow sorting. Journal of Visualized Experiments. 2012;67:4111.
  • Venugopal C, Wang SX, Manoranjan B, McFarlane N, Nolte S, Li M, Murty N, Siu MKW, Singh SK. GBM secretome induces transient transformation of human neural precursor cells. Journal of Neuro-Oncology. 2012;109:457-466.
  • Manoranjan B, Venugopal C, McFarlane N, Doble BW, Dunn SE, Scheinemann K, Singh SK. Medulloblastoma stem cells: Where development and cancer cross pathways. Pediatric Research. 2012;71:516-522.
  • Venugopal C, Li N, Wang X, Manoranjan B, Hawkins C, Gunnarsson T, Hollenberg R, Klurfan P, Murty N, Kwiecien J, Wynder C, Singh SK. Bmi1 marks intermediate precursors during differentiation of human brain tumor initiating cells. Stem Cell Research. 2012;8:141-153.
  • Salehi F, Scheithauer BW, Kovacs K, Horvath E, Syro LV, Sharma S, Manoranjan B, Cusimano M. MGMT immunohistochemical expression in pituitary corticotroph adenomas. Neurosurgery. 2012;70:491-496.
  • Wang X, Venugopal C, Manoranjan B, McFarlane N, O’Farrell E, Nolte S, Gunnarsson T, Hollenberg R, Kwiecien J, Northcott P, Taylor M, Hawkins C, Singh SK. Sonic hedgehog regulates Bmi1 in human medulloblastoma brain tumor-initiating cells. Oncogene. 2012;31:187-199.
  • Manoranjan B, Syro LV, Scheithauer BW, Ortiz LD, Horvath E, Salehi F, Kovacs K, Cusimano MD. Undifferentiated sarcoma of the sellar region. Endocrine Pathology. 2011;22:159-164.
  • Manoranjan B, Provias JP. Congenital brain tumors: Diagnostic pitfalls and therapeutic interventions. Journal of Child Neurology. 2011;26:599-614.
  • Salehi F, Scheithauer BW, Moyes VJ, Drake WM, Syro LV, Manoranjan B, Sharma S, Horvath E, Kovacs K. Low immunohistochemical expression of MGMT in ACTH secreting pituitary tumors of patients with Nelson syndrome. Endocrine Pathology. 2010;21:227-229.
  • Manoranjan B, Salehi F, Scheithauer BW, Rotondo F, Kovacs K, Cusimano MD. Estrogen receptors alpha and beta immunohistochemical expression: Clinicopathological correlations in pituitary adenomas. Anticancer Research. 2010;30:2897–2904.
  • Manoranjan B, Provias JP. Hemimegalencephaly: A fetal case with neuropathological confirmation and review of the literature. Acta Neuropathologica. 2010;120:117–130.
  • Cusimano MD, Mascarenhas AM, Manoranjan B. Spinal cord injuries due to diving: A framework and call for prevention. Journal of Trauma. 2008;65:1180-1185.
Nicholas Holzapfel

Prior to entering the MD/ PhD program at McMaster University, I completed an Honours Bachelor of Science specializing in Laboratory Medicine and Pathobiology at the University of Toronto. I am currently pursuing my PhD in the lab of Dr. Kristin Hope in the Stem Cell and Cancer Research Institute at McMaster. My PhD focuses on understanding the molecular pathways involved in the maintenance of normal hematopoietic stem cells and leukemic stem cells. I am particularly interested in how RNA-binding proteins post-transcriptionally regulate gene expression in these stem cell populations.

Publications

  • Rentas S, Holzapfel N, Hope KJ, Cancer Stem Cells: Prospective Isolation and Progress Towards Functional Biomarker Characterization, 2013, Current Pathobiology Reports
Siddharth Nath
S Nath

I completed my undergraduate studies in the Honours Biochemistry program at McMaster University in June 2013 and joined the MD/PhD program in September 2013. Under the expert supervision of Dr. Ray Truant in the Department of Biochemistry and Biomedical Sciences, my research is focused on investigating the basic cellular biology and biochemistry underlying genetic neurodegenerative disorders such as Huntington’s disease and the spinocerebellar ataxias. Understanding how these devastating disorders manifest at the cellular and molecular level may ultimately lead to the development of better therapies, while providing insight into basic cellular processes relevant to a wide array of other human diseases. My work has been generously funded through awards from the Canadian Institutes of Health Research, the Huntington Society of Canada, and various institutional scholarships.

Contact: naths3@mcmaster.ca

Publications

  • Nath, S., Munsie, L.N., and Truant, R. (2015) A huntingtin-mediated fast stress response halting endosomal trafficking is defective in Huntington’s disease. Human Molecular Genetics, 24 (2) 450-462; PMID 25205111.
Randa Stringer

Randa StringerI completed my undergraduate degree studying genetics and biological anthropology at the University of Western Ontario in 2013.  During that time my research focused primarily on the epigenetics of fetal alcohol spectrum disorders (FASD), with a summer spent studying dyslipidemias.
In the fall of 2013 I entered the MD/PhD program here at McMaster University, where I have continued my research in epigenetics.  Under the supervision of Dr. Guillaume Paré and Dr. Sonia Anand I am using genetic data from several large birth cohorts to investigate the effects of maternal exposures, particularly dietary patterns, on the epigenome of the offspring.  In utero exposures such as these can have profound implications on the long-term health of the child, including his/her predisposition to chronic conditions in later life like cardiovascular disease and diabetes.  By working to elucidate the role of epigenetics in programming these changes, we hope to gain a better understanding of
the interaction between fetal genetics and the maternal environment, and provide better guidelines for maternal nutrition during pregnancy.

 

Publications

  • Lin X.H., Sjaarda J., Dyck J., Stringer R., Hillis C., Harvey M., Carter R., Ainsworth P., Leber B., Pare G., Sadicovic B. (2015). Gender and BCR-ABL transcript type are correlated with molecular response to imatinib treatment in patients with chronic myeloid leukemia. European Journal of Haematology

  • Kleiber M.L., Laufer B.I., Stringer, R.L., Singh, S.M.. (2014). Third trimester-equivalent ethanol exposure is characterized by an acute cellular stress response and an ontogenetic disruption of genes critical for synaptic establishment and function in mice. Developmental Neuroscience.

  • Dube J., Wang J., Cao H., McIntyre A., Johansen C., Hopkins S., Stringer R., Hosseinzadeh S., Kennedy B., Ban M., Young K., Dewailly E., Bjerregaard P., Boyer B., Hegele R.. (2014). The private, common LDLR p.G116S variant has a large effect on plasma LDL cholesterol in circumpolar Inuit populations. Circulation: Cardiovascular Genetics. : 1-32.

  • Stringer RL , Laufer BI , Kleiber ML , Singh SM. (2013). Reduced expression of brain cannabinoid receptor 1 (Cnr1) is coupled with an increased complementary micro-RNA (miR-26b) in a mouse model of fetal alcohol spectrum disorders. Clinical Epigenetics. 5(1): 1-4.
Calvin Hsiung Yeh
TBA
Alexander Oberc

A. ObercI started my MD at McMaster in September 2013 and I transferred into the MD/PhD program the following year. I previously graduated with an Honors BMSc at Western University in 2013. I am currently working in the lab of Dr. Brian Coombes studying the relationship between gut microorganisms and Crohn's disease. Crohn's disease is an immune-mediated intestinal illness and Canada has one of the highest rates of Crohn's in the world. The pathophysiology of Crohn's disease is currently not well understood. My research focuses on one particular bacteria associated with ileal Crohn's disease known as adherent-invasive E. coli. I am investigating how this bacterium interacts with other known genetic and environmental risk factors for Crohn's. I've been awarded the CGS-Master's award to support my research. I am clinically interested in inflammatory bowel disease as well as infectious diseases.

e-mail: alexander.oberc@medportal.ca

Conferences

  • Alexander Oberc and Brian K. Coombes. Investigating the relationship between Crohn's disease risk factors and adherent-invasive E. coli. CNMSRS (2015)
Aadil Bharwani

A. BharwaniUpon completing my Honours B.Sc. in Biology & Psychology at McMaster, I entered the MD/PhD stream in 2015. Under the tutelage of Dr. John Bienenstock and Dr. Paul Forsythe, I am investigating the functional relationship between the intestinal microbiome and stress-induced changes in brain and behaviour. There is a body of work demonstrating the systemic role of the microbial community in influencing neural development and function. My project endeavours to assess the effect of modulating the composition and function of the gut microbiota on stress-induced disruptions, and unravel the mechanistic pathways—such as the vagus and immune system—that underlie this relationship.

Publications

  • Bharwani, A., Bienenstock, J., & Forsythe, P. (2015) The Gut Microbiome: Pathways to Brain, Stress, & Behavior. In Allen-Vercoe, E. and Tetro, J. A. (Eds.), The Microbiome Handbook. In press
  • Andrews, P.W., Bharwani, A., Kyuwon, R.L., Fox, M., & Thomson, J.A. (2015). Is serotonin an upper or a downer?  The evolution of the serotonergic system and its role in depression and the antidepressant response. Neuroscience & Biobehavioral Reviews, 51, 164-188
  • Bharwani, A., Vinski, M., Watter, S., & Andrews, P. W. (2014). It's All About Me: Stressor-Task Relatedness Influences Task Utility and Performance in Depression. Canadian Journal of Experimental Psychology-Revue Canadienne de Psychologie Experimentale, 68(4), 288-289.
Madelaine Leung

M. LeungI graduated from Queen’s University in 2014 with a BScH in Biochemistry, and started an MSc in Chemical Biology at McMaster University.  The following year I transferred into the MD/PhD program.  My research is in medicinal chemistry and drug discovery, under Dr. Fred Capretta.  I am focusing on the synthesis of chemical libraries, with the purpose of discovering and developing inhibitors of aminoglycoside nucleotidyltransferases and other aminoglycoside modifying enzymes.  As aminoglycoside modifying enzymes are a key mechanism of bacterial resistance, inhibition of these enzymes should rescue the activity of obsolete drugs, allowing them to be effective again.

Graduates

Derek Chu

Derek ChuAfter completing my BHSc at McMaster in 2008, I joined the MD/PhD program to study mechanisms of allergic sensitization to food, particularly to peanut under the superperb mentorship of Dr. Manel Jordana. Peanut allergy affects ~1-2% of the North American population and is a severe food hypersensitivity in that, unlike many others, it is highly associated with anaphylaxis and typically not outgrown. My projects have taken me to work on how epithelia instruct for Th2 responses in in house-dust mite-induced allergic asthma and peanut allergy, for which I've been fortunate enough to be awarded a Vanier doctoral award from CIHR. Clinically, I have an interest in diseases involving the immune system, and look forward to my clerkship experience. I am actively involved in immunology curriculum development for the MD program.

ps. Jeremy was once my TA!

e-mail: chudk@mcmaster.ca or derek.chu@medportal.ca

Publications

  • 1. Al-Garawi A, Fattouh R, Botelho F, Walker TD, Goncharova S, Moore CL, Mori M, Erjefalt JS, Chu DK, Humbles AA, Kolbeck R, Stampfli MR, O'Byrne PM, Coyle AJ, Jordana M. Influenza A facilitates sensitization to house dust mite in infant mice leading to an asthma phenotype in adulthood. Mucosal Immunol. 2011 Aug 31. doi: 10.1038/mi.2011.35. [Epub ahead of print]
  • 2. Arias K, Chu DK, Flader K, Botelho F, Walker T, Arias N, Humbles AA, Coyle AJ, Oettgen HC, Chang HD, Van Rooijen N, Waserman S, Jordana M. Distinct immune effector pathways contribute to the full expression of peanut-induced anaphylactic reactions in mice. J Allergy Clin Immunol. 2011 Jun;127(6):1552-61.e1.
  • 3. Arias K, Baig M, Colangelo M, Chu D, Walker T, Goncharova S, Coyle A, Vadas P, Waserman S, Jordana M. Concurrent blockade of platelet-activating factor and histamine prevents life-threatening peanut-induced anaphylactic reactions. J Allergy Clin Immunol. 2009 Aug;124(2):307-14, 314.e1-2. Epub 2009 May
  • 4. MacGillivray L, Hernandez J, Maedler C, Chu D, Margetts P. Developing Clinician Scientists: The MD/PhD Program at McMaster University (2009). McMaster University Medical Journal 6: 5-10.
  • 5. Llop-Guevara A, Colangelo M, Chu DK, Moore CL, Stieber NA, Walker TD, Goncharova S, Coyle AJ, Lundblad LK, O'Byrne PM, Lovric M, Jordana M. In vivo-to-in silico iterations to investigate aeroallergen-host interactions. PLoS One. 2008 Jun 11;3(6):e2426.

Conferences

  • Derek K. Chu, Alba Llop-Guevara, Tina D. Walker, Kristin Flader, Cheryl Lynn Moore, Susanna Goncharova, Jeanette Boudreau, Waliul Khan, Michael Comeau, Alison Budelsky, Roland Kolbeck, Alison A. Humbles, and Manel Jordana. The Epithelial-derived Cytokines TSLP, IL-33, and IL-25 Converge on OX40L to Elicit Peanut Allergy and Anaphylaxis in Mice. Late breaking Abstract, AAAAI 2011.
Benny Dua

David BulirI am currently enrolled in the combined MD/PhD program at McMaster University. Prior to entering the program in 2009, I have completed a Master's degree in Medical Science and an Honours Bachelor's degree in Science, both at McMaster University. Under the supervision of Dr. Paul O'Byrne at the McMaster University Medical Centre, my research involves examining the role of dendritic cells in the pathophysiology of allergen-induced airway responses in allergic asthmatics.

Publications

  • Kinoshita T, Baatjes A, Smith SG, Dua B, Watson R, Kawayama T, Larche M, Gauvreau GM, O'Byrne PM. Natural regulatory T cells in isolated early responders compared with dual responders with allergic asthma. Journal of Allergy and Clinical Immunology. (In press)
  • Gauvreau GM, Boulet LP, Cockcroft DW, FitzGerald JM, Mayers I, Carlsten C, Laviolette M, Killian K, Davis BE, Larché M, Kipling C, Dua B, Mosesova S, Putnam W, Zheng Y, Scheerens H, McClintock D, Matthews J, O'Byrne PM. OX40L blockade and allergen-induced airway responses in subjects with mild asthma. Clinical and Experimental Allergy. (In press).
  • Tang W, Smith S, Beaudin S, Dua B, Howie K, Gauvreau G, O'Byrne P. IL-25 and IL-25 receptor expression on eosinophils from subjects with allergic asthma. International Archives of Allergy and Immunology. 2013;163:5-10.
  • Dua B, Smith S, Kinoshita T, Imaoka H, Gauvreau GM, O'Byrne PM. Myeloid dendritic cells type 2 in allergic asthma. Allergy. 2013;68:1322-1326.
  • Imaoka H, Gauvreau GM, Watson RM, Smith SG, Dua B, Baatjes AJ, Howie K, Hoshino T, Killian KJ, Aizawa H, O'Byrne PM. Interleukin-18 and interleukin-18 receptor- expression in allergic asthma. European Respiratory Journal. 2011;38:981-983.
  • Zahida M, Dua B, Watson RM, Gauvreau GM, O'Byrne PM. Allergen inhalation challenge in smoking compared to non-smoking asthmatic subjects. Clinical and Experimental Allergy. 2011;41:1084-1090.
  • Dua B, Watson RM, Gauvreau GM, O'Byrne PM. Myeloid and plasmacytoid dendritic cells in induced sputum after allergen inhalation in subjects with asthma. Journal of Allergy and Clinical Immunology. 2010;126:133-139.
Jeremy Hernandez
Jeremy Hernandez

I have been in the McMaster MD/PhD Program since September 2007. Prior to entering the program, I obtained an Honors BSc. in Physiology from the University of Western Ontario (2005) and started my MSc. in Medical Sciences at McMaster. I am currently pursuing my PhD with the Asthma Research group at the Firestone Institute of Respiratory Health (St. Joseph's Healthcare). My research interests lie in the pathophysiology of airway smooth muscle contractility and hyperresponsiveness in asthma, with an emphasis on the effects of acute stretch on airway responsiveness and its contribution to bronchoconstriction.

Publications

  • Hernandez JM and Janssen LJ (2010). TP-receptor activation amplifies airway stretch-activated contractions assessed in perfused intact bovine bronchial segments. J Pharmacol Exp Ther [Epub ahead of print]
  • Hernandez JM and Janssen LJ. The role of L-type calcium channel activation in airway stretch-activated contractions. Submitted to J Pharmacol Exp Ther.
  • Noble PB, Hernandez JM, Mitchell HW and Janssen LJ (2010). Deep inspiration and airway physiology: human, canine, porcine, or bovine? J Appl Physiol 109: 938–939.
  • MacGillivray L, Hernandez J, Maedler C, Chu D, Margetts P. Developing Clinician Scientists: The MD/PhD Program at McMaster University (2009). McMaster University Medical Journal 6: 5-10.
  • Hernandez JM, Cox G and Janssen LJ (2008). Involvement of the neurokinin-2 receptor in airway smooth muscle stretch-activated contractions assessed in perfused intact bovine bronchial segments. J Pharmacol Exp Ther 327(2):503-10.
  • Janssen LJ, Mueed I, Hirota JA, Khan A, Ghayur MN, Hirota SA, Helli PB, and Hernandez JM (2007). Chapter: Excitation-contraction coupling and signalling in smooth muscle. Textbook Title: New Frontiers in Smooth Muscle Biology and Physiology. Pages: 57-83.
  • Prior T, Hernandez J, Tougas G, and Rangachari PK (2004). Phenotypic differences in cholinergic responses of distal colonic epithelium. Exp Physiol 89(2):209-17.
Lindsey MacGillivray
Lindsey MacGillivray

I graduated from the Honours BSc Biology program at St. Francis Xavier University in 2005. I entered the Master of Science medical sciences program at McMaster later that fall, transferred one year later to the PhD program and again a year later to the newly formed MD/PhD program at McMaster University. I am presently enrolled in year 6 of the MD/PhD program and have just recently completed my PhD thesis entitled: “Regulation of brain serotonergic and dopaminergic neurons: the modulatory effects of selective serotonin reuptake inhibitors, atypical neuroleptics and environmental enrichment.” Though I am continuing to publish my work, I have re-entered medical clerkship and will graduate with both degrees in May, 2012.

Publications

  • MacGillivray, L., Lagrou, L.L., Reynolds, K.B., Rosebush, P.I. and Mazurek MF. 2010. Role of serotonin transporter inhibition in the regulation of tryptophan hydroxylase in brainstem raphe nuclei: Time course and regional specificity. Neuroscience. 171(2): 407-420.
  • Reynolds, KB, MacGillivray, L., Zettler, M., Rosebush, P.I. and Mazurek MF. 2011. Role of the dopamine transporter in mediating the neuroleptic-induced reduction of tyrosine hydroxylase-immunoreactive midbrain neurons. Brain Research. March 8: Epub ahead of print.
  • MacGillivray, L., Hernandez, J., Maedler, C., Chu, D. and Margetts, P. 2009. Developing clinician scientists: The MD/PhD program at McMaster University. McMaster University Medical Journal. 6(1): 5-10.
  • MacGillivray, L. 2009. I feel your pain: mirror neurons and empathy. McMaster University Medical Journal. 6(1): 16-20.
  • MacGillivray, L. 2009. I feel your pain: A sense of empathy. In D. Shore (Ed.), Psych 3D03 The Multisensory Mind. Hamilton: McMaster University Press.
  • MacGillivray, L., Reynolds, K.B., Lagrou, L.L., Rosebush, P.I. and Mazurek MF. Inhibition of the serotonin transporter induces microglial activation and downregulation of dopaminergic neurons in the substantia nigra. Submitted to Synapse.
  • MacGillivray, L., Reynolds, K.B., Rosebush, P.I. and Mazurek MF. Independent effects of environmental enrichment with exercise and serotonin transporter blockade on serotonergic neurons in the dorsal raphe nucleus. Submitted to Neuroscience Letters.
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