Sonia Anand

2015 Publications

• Valera B, Sohani Z, Rana A, Poirier P, Anand SS. The ethno-epidemiology of obesity. Can J Cardiol 2015 Feb;31(2):131-41
• D';Mello MJ, Ross SA, Briel M, Anand SS, Gerstein H, Pare G. The association between shortened leukocyte telomere length and cardio-metabolic outcomes: A systematic review and meta-analysis. Circ Cardiovasc Gene  2015 Feb; 8(1):82-90.
• Samani N, Nelson C, Hamby S, Salehee N, Hopewell J, Zeng L, Kononi S, Willenborg C, Amouyel P, Anand S, Blankenberg S, Boehm B, Clarke R, Collins R, Dedousi, Farrall M, Franks P, Groop L, Hall AS, Hamsten A, Hengstenberg C, Hovingh G, Ingelsson E, Kathiresan S, Kee F, Koenigh I, Kooner J, Lehtimaki T, Maerz W, McPherson R, Metspalu An, Nieminen M, O';Donnell C, Palmer CN, Peters, Muredach, Ripatti S, Roberts R, Baas F, Salomaan V, Shah S, Schreiber S, Siegbahn A, Thorsteinsdottir U, Veronesi G, Wareham N, Cristen, Zalloua P, Erdmann J, Deloukas P, Watkins H, Schunkert, Thompson J, Hengstenberg C. Genetically-Determined Height and Coronary Artery Disease. NEJM  (In Press Feb 2015)
• Shah B, Hwee J, Anand SS,  Austin P, Manuel D, Hux J. Family physician ethnicity influences quality of diabetes care for Chinese but not South Asian patients. Primary Care Diabetes (In Press Feb 2015)
• Samaan MC, Anand SS,  Sharma AM, Samjoo IA, Tarnopolsky MA. Sex differences in skeletal muscle Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) levels: A cross-sectional study. Sci Rep 2015 Mar 17;5:9154
• Nead K, Li A, Wehner R, Neupane B, Gustafsson S, Butterworth A, Engert J, Davis A, Hegele R, Mille R, den Hoed M, Khaw KT, Kilpeläinen TO, Wareham N, Edwards T, Hallmans G, Varga T, Kardia S, Smith J, Zhao W, Faul J, Weir D, Mi K, Xi B, Quinteros s, Cooper C, Sayer A, Jameson L, Grøntved A, Fornage M, Sidney S, Hanis C, Highland H, Häring J, Heni M, Lasky-Su J, Weiss S, Gerhard G, Still C, Melkaey, Melka M, Pausova Z, Paus T, Grant S, Hakonarson H, Price R, Wang K, Scherag A, Hebebrand J, Hinney A, BioBank Japan, AGEN-BMI, GIANT Consortium, Franks P, Frayling T, McCarthy, Hirschhorn J, Loos R, Ingelsson E, Gerstein HC, Yusuf S, Beyene J, Anand SS, Meyre D. Contribution of common non-synonymous variants in PCSK1 to body-mass index variation and risk of obesity: a systematic review and meta-analysis with evidence from up to 331,175 individuals. Hum Mol Genet  2015 March 17 [Epub ahead of print]
• Sohani ZN, Meyre D, de Souza RJ, Joseph PG, Gandhi M, Dennis BB, Norman G,Anand SS. Assessing the quality of published genetic association studies: the Q-Genie Tool. Journal of Epidemiology (In Press April 2015)
• Takaro T , Scott J, Allen R, Anand SS, Becker A, Befus A, Brauer M, Duncan J, Lefebvre D, Lou W, Mandhane P, McLean K, Miller G, Sbihi H, Shu H, Subbarao P, Turvey S, Wheeler A, Zeng L, Sears M, Brook J, and the CHILD Study investigators. The Canadian Healthy Infant Longitudinal Development (CHILD) Study: Examining developmental origins of allergy and asthma. Journal of Exposure Science and Environmental Epidemiology (In Press May 2015)
• Samaan Z, Garasia S, Gerstein HC, Engert JC, Mohan V, Diaz R, Yusuf S, Anand SS, Meyre D. Lack of association between type 2 diabetes and major depression: epidemiologic and genetic evidence in a multiethnic population. Transl Psychiatry (In Press June 2015)
• Fernando E, Razak F, Lear S,  Anand SS. Cardiovascular Disease in South Asian Migrants. Can J Cardiol (In Press July 2015)

2014 Publications

• Moerman JN, Ratjen F, Subbarao P, Sears M, Anand SS, Stanojevic S. The Prevalence of Asthma in Canadian Children of South Asian Descent. Pediatr Pulmonol 2014 Jan; 49(1):43-8.
• Joseph P, Pare G, Ross S, Roberts R, Anand SS.  Pharmacogenetics in Cardiovascular Disease:  The Challenge of Moving from Promise to Realization.  Clin Cardiol 2014 Jan; 37(1):48-56.
• Yoneyama S, Guo Y, Lanktree MB, Barnes MR, Elbers CC, Karczewski KJ, Padmanabhan S, Bauer F, Baumert J, Beitelshees A, Berenson GS, Boer JM, Burke G, Cade B, Chen W, Cooper-Dehoff RM, Gaunt TR, Gieger C, Gong Y, Gorski M, Heard-Costa N, Johnson T, Lamonte MJ, McDonough C, Monda KL, Onland-Moret NC, Nelson CP, O'Connell JR, Ordovas J, Peter I, Peters A, Shaffer J, Shen H, Smith E, Speilotes L, Thomas F, Thorand B, Monique Verschuren WM, Anand SS, Dominiczak  A, Davidson KW, Hegele RA, Heid I, Hofker MH, Huggins GS, Illig T, Johnson JA, Kirkland S; the Look AHEAD Research Group, König W, Langaee TY, McCaffery J, Melander O, Mitchell BD, Munroe P, Murray SS, Papanicolaou G, Redline S, Reilly M, Samani NJ, Schork NJ, Van Der Schouw YT, Shimbo D, Shuldiner AR, Tobin MD, Wijmenga C, Yusuf S; the GIANT Consortium; the CARe IBC Consortium, Hakonarson H, Lange LA, Demerath EW, Fox CS, North KE, Reiner AP, Keating B, Taylor KC. Gene-centric meta-analyses for central adiposity traits in up to 57 412 individuals of European  descent confirm known loci and reveal several novel associations. Hum Mol Genet. 2014 Jan 6. [Epub ahead of print].
• Lear S, Teo K, Gasevice D, Zhang M, Poirier P, Rangarajan S, Seron P, Kelishadi R, Tamil A, Kruger A, Iqbal R, Swidan H, Gomez-Arbelaez D, Yusuf R, Chifamba J, Kutty V, Karsidag K, Kumar R, Li W, Szuba A, Avezum A, Diaz R, Anand SS, Rosengren A, Yusuf S. Prospective Urban Rural Epidemiology (PURE) study. The association between ownership of common household devices with obesity and diabetes in high, middle, and low income countries. CMAJ 2014 Mar4; 186(4):258-66.
• Rashid S, Sniderman A, Melone M, Brown PE, Otvos JD, Mente A, Schulze K, McQueen MJ, Anand SS, Yusuf S. Elevated cholesterol ester transfer protein (CETP) activity, a major determinant of the atherogenic dyslipidemia, and atherosclerotic cardiovascular in South Asians. Eur J Prev Cardiol. 2014 Mar 21.
• Bailey S, Xie C, Paré G, Montpetit A, Mohan V, Yusuf S, Gerstein H, Engert JC, Anand SS, on behalf of the EpiDREAM and INTERHEART investigators. Variation at the Dipeptidyl Peptidase IV (DPP4) Locus Influences Apolipoprotein B Levels in South Asians and Exhibits Heterogeneity in Europeans Caused by Body Mass Index. Diabetologia 2014 Apr; 57(4):738-45.
• Kreatsoulas C, Anand SS, Subramanian S. A new emerging double burden of disease: The prevalence of individuals with cardiovascular disease and cancer. J Intern Med 2014 May; 275(5):494-505.
• Banerjee AT, Kin R, Strachan PH, Boyle MH, Anand SS, Oremus M. Factors facilitating the implementation of church-based heart health promotion programs for older adults: A qualitative study guided by the precede-proceed model. Am J Health Promot 2014 May 12.
• Ross S, Eikelboom J, Anand SS, Eriksson N, Gerstein HC, Mehta S, Connolly SJ, Rose L, Ridker PM, Wallentin L, Chasman DI, Yusuf S, Pare G. Association of cyclooxygenase-2 genetic variant with cardiovascular disease. Eur Heart J. 2014 Sep 1;35(33:2242-8a.
• Spencer FA, Gurwitz JH, Schulman S, Linkins LA, Crowther MA, Ginsberg JS, Lee AY, Sacynski JS, Anand SS, Lessard D, Emery C, Huang W, Goldberg RJ. Venous Thromboembolism in Older Adults: A community-based Study. Am J Med 2014 Jun; 127(6):530-7.
• Leong DP, Smyth A, Teo KK, McKee M, Rangarajan S, Pais P, Liu L, Anand SS, Yusuf S. Patterns of alcohol consumption and myocardial infarction risk: observations from 52 countries in the INTERHEART case-control study. Circulation 2014 Jul 29; 130(5):390-8.
• Rana A, de Souza R, Kandasamy S, Lear S, Anand SS. Cardiovascular Risk in South Asians Living in Canada: A Systematic Review and meta-analysis. CMAJ Open 2014 Jul 22;2(3):E183-91
• Leong D, Smyth A, Teo K, McKee M, Rangarajan S, Pais P, Liu L, Anand SS, Yusuf S. Patterns of alcohol consumption and myocardial infarction risk: observations from 52 countries in the INTERHEART case-control study. Circulation 2014 Jul 29;130(5):390-8.
• Yusuf S, Rangarajan S, Teo K, Islam S, Li W, Liu L, Bo J, Lou Q, Lu F, Liu T, Yu L, Zhang S, Mony P, Swaminathan S, Mohan V, Gupta R, Kumar R, Vijayakumar K, Lear S, Anand S, Wielgosz A, Diaz R, Avezum A, Lopez-Jaramillo P, Lanas F, Yusoff K, Ismail N, Iqbal R, Rahman O, Rosengren A, Yusufali A, Kelishadi R, Kruger A, Puoane T, Szuba A, Chifamba J, Oguz A, McQueen M, McKee M, Dagenais G; PURE Investigators. Cardiovascular risk and events in 17 low, middle and high income countries. N Engl J Med 2014 Aug28;371(9):818-27
• Punthakee Z, Almeras N, Despres JP, Dagenais G, Anand S, Hunt D, Sharma A, Jung H, Yusuf S, Gerstein H. Impact of Rosiglitazone on Body Composition, Hepatic Fat, Fatty Acids, Adipokines and Glucose in Persons with Impaired Fasting Glucose Tolerance, A Substudy of the DREAM Trial. Diabet Med 2014 sep; 31(9):1086-92.
• Stanojevic S, Sha B, Subbarao P, Sears M, Anand S, Jiandong S. The burden of Asthma amongst the South Asian and Chines Population Living in Ontario, Canada.  Can Respir J 2014 Sep 3.
• de Souza RJ, Anand SS. CVD in Asian Americans: Unmasking Heterogeneity. J Am Coll Cardiol 2014;64:2495-97
• Sohani ZN, Deng WQ, Pare G, Meyre D, Gerstein H, Anand SS. Does genetic heterogeneity account for the divergent risk of type 2 diabetes mellitus in South Asian and white Caucasian populations? Diabetologia 2014 Nov;57(11):2270-81.

2013 Publications

• Raitakari O, Mäkinen V, McQueen M, Niemi J, Juonala M, Jauhiainen M, Salomaa V, Hannuksela M, Savolainen M, Kesäniemi Y, Kovanen P, Sundvall J, Solakivi T, Loo B, Marniemi J, Hernesniemi J, Lehtimäki T, Kähönen M, Peltonen M, Leiviskä J, Jula A, Anand SS, Miller R, Yusuf S, Viikari J, Ala-Korpela M. Computationally estimated apolipoproteins B and A1 in predicting cardiovascular risk. Atherosclerosis 2013 Jan;226(1):245-51.
• Joseph P, Pare G, Anand SS. Exploring Gene-Environment Relationships in Cardiovascular Disease. Can J Cardio 2013 Jan;29(1);37-45
• Morrison K, Anand SS, Yusuf S, Atkinson S, Schulze K, Rao-Melacini P, McQueen M, McDonald S, Persadie R, Hunter B, Bourgeois J, Jansen J, Teo KK. FAMILY (Family Atherosclerosis Monitoring In earLY life) Study Investigators. Maternal and pregnancy related predictors of cardiometabolic traits in newborns. PloS One 2013;8(2):e55815.
• Anand SS. Vasudevan A, Gupta M, Morrison K, Kurpad A, Teo KK, Srinivasan K, On behalf of the START Cohort Study Investigators. Rationale and Design of South Asian Birth Cohort (START): A Canada-India Collaborative Study BMC Public Health 2013, Jan 28; 13:79
• Kreatsoulas C, Anand SS. Menopausal hormone therapy for the primary prevention of chronic conditions. U.S. Preventative Services Task Force recommendation statement. Pol Arch Med Wewn. 2013:123(3): 112-7.
• Gravely S, Anand SS, Stewart DE, Grace SL, on behalf of the CRCARE Investigators. Effect or referral strategies on access to cardiac rehabilitation among women. Eur J Prev Cardiol 2013 Mar. 11 [Epub ahead of print]
• Kreatsoulas C, Shannon HS, Giacomini M, Velianou JL, Anand SS. Reconstructing Angina: Cardiac Symptoms Are the Same in Women and Men. JAMA Internal Medicine 2013 Apr. 8:1-2.
• Neylon A, Canniffe C, Anand S, Kreatsoulas c, Blake GJ, Sugrue D, McGorrian D. A global perspective on psychosocial risk factors for cardiovascular disease. Prog Cardiovasc Dis. 2013 May-Jun;55(6): 574-81.
• Kalra S, Mercuri M, Anand SS. Measures of body fat in South Asian Adults. Nutr Diabetes 2013 May 27;3:e69
• Chetty T, Damjanovic S, Gerstein H, Singh N, Yusuf S, Anand SS, Sharma A. Metabolic effects of Telmisartan in subjects with abdomen obesity: a prospective randomized control trial. Blood Pressure, 2013; Jun 3
• Mente A, Meyre D, Lanktree M, Heydarpour M, Davis AD, Miller R, Gerstein H, Hegele RA, Yusuf S, Anand SS. Causal Relationship between Adiponectin and Metabolic Traits: A Mendelian Randomization Study in a Multiethnic Population. PLoS One 8(6): e66808 [Epub ahead of print]
• Wahi G, Wilson J, Miller R, Anglin R, McDonald S, Morrison KM, Teo KK, Anand SS. Aboriginal birth cohort (ABC): a prospective cohort study of early life determinants of adiposity and associated risk factors among Aboriginal people in Canada. BMC Public Health 2013 Jun 25;13(1):608. [Epub ahead of print]
• Anand SS, Meyre D, Pare G, Bailey S, Xie C, Zhang X, Montpetit A, Desai D, Bosch J, Mohan V, Diaz R, McQueen M, Cordell H, Keavney B, Yusuf S, Gaudet D, Gerstein H, Engert JC, on behalf of the EpiDREAM Genetics Investigators. Genetic Information and the Prediction of incident Type 2 Diabetes in a High- Risk Multi-Ethnic population: The EpiDREAM Genetic Study. Diabetes Care 2013 Sep;36(9):2836-42
• Shah BR, Victor JC, Chiu M, Tu JV, Anand SS, Austin PC, Manuel DG, Hux JE. Cardiovascular Complications and Mortality After Diabetes Diagnosis for South Asian and Chinese Patients: A population-based cohort study. Diabetes Care 2013 Sep;36(9):2670-6
• Pare, Guillaume; Kubo, Michiaki; Byrd, James B.; McCarty, Catherine A.; Woodard-Grice, Alencia; Teo, Koon K.; Anand, Sonia S.; Zuvich, Rebecca L.; Bradford, Yuki; Ross, Stephanie; Nakamura, Yusuke; Ritchie, Marylyn; Brown, Nancy J. Genetic variants associated with angiotensin-converting enzyme inhibitor-associated angioedema. Pharmacogenetics and Genomics 2013; 23:470-78
• Oliveira A, Kalra S, Wahi G, McDonald S, Desai D, Wilson J, Jacobs L, Smoke S, Hill P, Hill K, Morrison K, Teo K, Miller R, Anand SS. Maternal and Newborn Health Profile in an Aboriginal Community in Canada. Journal of Obstetrics and Gynaecology Canada (In Press July 2013)
• Joseph P, Pare G, Ross S, Roberts R, Anand SS. Pharmacogenetics in Cardiovascular Disease: The Challenge of Moving from Promise to Realization. Clinical Cardiology (In Press July 2013).
• Wahi G, Anand SS. Race/Ethnicity, obesity and related cardio-metabolic risk factors: A life-course perspective. Curr Cardiovasc Risk Rep (In Press Aug 2013)
• Moerman JN, Ratjen F, Subbarao P, Sears M, Anand SS, Stanojevic S. The Prevalence of Asthma in Canadian Children of South Asian Descent. Pediatr Pulmonol (In Press Aug 2013)

2012 Publications

• Zbuk K, Anand SS. Declining incidence of breast cancer after decreased use of hormone-replacement therapy: magnitude and time-lags in different countries. J Epidemiol Community Health 2012 Jan;66(1):1-7
• Kochan AM, Wolever TMS, Damjanovic S, Chetty VT, Anand SS, Gerstein HC, Sharma A.  Glycemic Index Predicts Individual Glucose Repsonses After a Breakfast Meal in Free-Living Adults with Abdominal Obesity. J Nutr 2012 Jan;142(1):27-32
• Johansen CT, Wang, J, McIntyre AD, Martins RA, Ban MR, Lanktree MB, Huff MW, Peterfy M, Mehrabian M, Lusis AJ, Kathiresan S, Anand SS, Yusuf S, Lee AH, Glimcher LH, Cao H, Hegele R. Excess of Rare Variants in Non-GWAS Study Candidate Genes in Patients with Hypertriglyceridemia. Circ Cardiovasc Genet 2012 Feb1;5(1):66-72
• Alonso-Coello P, Bellmunt S, McGorrian C, Anand SS, Guzman R, Criqui M, Akl E, Vandvik P, Lansberg M, Guyatt G, Spencer F. Antithrombotic Therapy in Peripheral Artery Disease: Antithrombotic Therapy and Prevention of Thrombosis, 9^th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012 Feb;141(2Suppl):e669S-90S
• Clarke R, Bennett D, Parish S, Verhoef P, Dötsch-Klerk M, Lathrop M, Xu P, Nordestgaard BG, Holm H, Hopewell JC, Saleheen D, Tanaka T, Anand SS, Chambers JC, Kleber ME, Ouwehand WH, Yamada Y, Elbers C, Peters B, Stewart AF, Reilly MM, Thorand B, Yusuf S, Engert JC, Assimes TL, Kooner J, Danesh J, Watkins H, Samani NJ, Collins R, Peto R,  for the MTHFR Studies Collaborative Group*. Homocysteine and coronary heart disease: meta-analysis of MTHFR case-control studies, avoiding publication bias. Plos Med.  2012 Feb;9(2):e1001177.
• Johansen CT, Wang J, McIntyre AD, Martins RA, Ban MR, Lanktree MB, Huff MW, Peterfy M, Mehrabian M, Lusis AJ, Kathiresan S, Anand SS, Yusuf S, Lee AH, Glimcher LH, Cao H, Hegele RA.  Excess of rare variants in non-genome-wide association study candidate genes in patients with hypertriglyceridemia.  Circ Cardiovasc Genet.  2012 Feb 1;5(1):66-72.
• Davies RW, Wells GA, Stewart AF, Erdmann J, Shah SH, Ferguson JF, Hall AS, Anand SS, Burnett MS, Epstein SE, Dandona S, Chen L, Nahrstaedt J, Loley C, Konig IR, Krasuss WE, Granger CB, Engert JC, Hengstenberg C, Wichmann He, Schreiber S, Tang WH, Ellis SG, Rader DJ, Hazen Sl, Reilly MP, Samani NJ, Schunkert H, Roberts R, McPerson R. A Genome Wide Association Study for Coronary Artery Disease Identifies a Novel Susceptibility Locus in the Major Histocompatibility Complex. Circ Cardiovasc Genet 2012 Apr 1;5(2):217-25
• Shah BR, Cauch-Dudek K, Anand SS, Austin PC, Manuel DG, Hux JE.  Absence of disparities in the quality of primary diabetes care for South Asians and Chinese in an urban Canadian setting.  Diabetes Care.  2012 Apr;35(4):794-6. 
• Pare G, Ross S, Mehta SR, Yusuf S, Anand SS, Connolly SJ, Fox KA, Eikelboom JW.  Effect of PON1 Q192R Genetic Polymorphism on Clopidogrel Efficacy and Cardiovascular Events in the Clopidogrel in the Unstable Angina to Prevent Recurrent Events Trial and the Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events.  Circ Cardiovasc Genet. 2012 Apr 1;5(2):250-6. 
• Ross S, Anand SS, Joseph P, Pare G.  Promises and challenges of pharmacogenetics:  an overview of study design, methodological and statistical issues.  J R Soc Med Cardiovasc 2012 Apr(1):12. 
• Banerjee AT, Boyle MH, Anand SS, Strachan PH, Oremus M.  The Relationship Between Religious Service Attendance and Coronary Hearth Disease and Related Risk Factors in Saskatchewan, Canada.  J Relig Health.  2012 May 11. 
• Voight BF, Peloso GM, Orho-Melander M, Frikke-Schmidt R, Barbalic M, Jensen MK, Hindy G, Hólm H, Ding EL, Johnson T, Schunkert H, Samani NJ, Clarke R, Hopewell JC, Thompson JF, Li M, Thorleifsson G, Newton-Cheh C, Musunuru K, Pirruccello JP, Saleheen D, Chen L, Stewart AF, Schillert A, Thorsteinsdottir U, Thorgeirsson G, Anand S, Engert JC, Morgan T, Spertus J, Stoll M, Berger K, Martinelli N, Girelli D, McKeown PP, Patterson CC, Epstein SE, Devaney J, Burnett MS, Mooser V, Ripatti S, Surakka I, Nieminen MS, Sinisalo J, Lokki ML, Perola M, Havulinna A, de Faire U, Gigante B, Ingelsson E, Zeller T, Wild P, de Bakker PI, Klungel OH, Maitland-van der Zee AH, Peters BJ, de Boer A, Grobbee DE, Kamphuisen PW, Deneer VH, Elbers CC, Onland-Moret NC, Hofker MH, Wijmenga C, Verschuren WM, Boer JM, van der Schouw YT, Rasheed A, Frossard P, Demissie S, Willer C, Do R, Ordovas JM, Abecasis GR, Boehnke M, Mohlke KL, Daly MJ, Guiducci C, Burtt NP, Surti A, Gonzalez E, Purcell S, Gabriel S, Marrugat J, Peden J, Erdmann J, Diemert P, Willenborg C, König IR, Fischer M, Hengstenberg C, Ziegler A, Buysschaert I, Lambrechts D, Van de Werf F, Fox KA, El Mokhtari NE, Rubin D, Schrezenmeir J, Schreiber S, Schäfer A, Danesh J, Blankenberg S, Roberts R, McPherson R, Watkins H, Hall AS, Overvad K, Rimm E, Boerwinkle E, Tybjaerg-Hansen A, Cupples LA, Reilly MP, Melander O, Mannucci PM, Ardissino D, Siscovick D, Elosua R, Stefansson K, O'Donnell CJ, Salomaa V, Rader DJ, Peltonen L, Schwartz SM, Altshuler D, Kathiresan S. Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study.  Lancet.  2012 Aug 11;380(9841):572-80 PubMed PMID: 22607825. 
• Neupane B, Loeb M, Anand SS, Beyene J.  Meta-analysis of genetic association studies under heterogeneity.  Eur J Hum Genet.  2012 May 30.  doi: 10.1038/ejhg.2012.75. 
• Zbuk K, Xie C, Young R, Heydarpour M, Pare G, Davis A, Miller R, Lanktree M, Saleheen D, Danesh J, Yusuf S, Engert J, Hegele R, Anand SS. BRCA2 Variants and Cardiovascular Disease in a Multi-Ethnic Study. BMC Med Genet  2012 July18;13-56
• Anand S, Dagenais G, Mohan V, Diaz R, Probstfield J, Freeman R, Shaw J, Marshall S, Lanas F, Avezum A, Budaj A, Jung H, Desai D, Bosch J, Yusuf S, Gertstein H. Glucose Levels are Associated with Cardiovascular Disease and Death in an International Cohort of Normal Glycemic and Dysglycemic Men and Women: The EpiDREAM Cohort Study. Eur J Cardiovas Prev Cardiol 2012 Aug;19(4):755-64
• McDonald SD, Yusuf S, Walsh MW, Lonn E, Teo K, Anand SS, Pogue J, Islam S, Devereaux PJ, Gerstein HC. Increased Cardiovascular Risk after Preeclampsia in Women with Dysglycemia. Diabet Med 2012 Oct 10. doi: 10.1111/dme.12033
• Samaan Z, Nowacki B, Schulze K, Magloire P, Anand S.  Smoking cessation intervention in a cardiovascular hospital based clinical setting. Cardiovascular Psychiatry and Neurology Volume 2012, Article ID 970108
• Asselbergs FW, Guo Y, van Iperen EP, Sivapalaratnam S, Tragante V, Lanktree MB, Lange LA, Almoguera B, Appelman YE, Barnard J, Baumert J, Beitelshees AL, Bhangale TR, Chen YD, Gaunt TR, Gong Y, Hopewell JC, Johnson T, Kleber ME, Langaee TY, Li M, Li YR, Liu K, McDonough CW, Meijs MF, Middelberg RP, Musunuru K, Nelson CP, O'Connell JR, Padmanabhan S, Pankow JS, Pankratz N, Rafelt S, Rajagopalan R, Romaine SP, Schork NJ, Shaffer J, Shen H, Smith EN, Tischfield SE, van der Most PJ, van Vliet-Ostaptchouk JV, Verweij N, Volcik KA, Zhang L, Bailey KR, Bailey KM, Bauer F, Boer JM, Braund PS, Burt A, Burton PR, Buxbaum SG, Chen W, Cooper-Dehoff RM, Cupples LA, Dejong JS, Delles C, Duggan D, Fornage M, Furlong CE, Glazer N, Gums JG, Hastie C, Holmes MV, Illig T, Kirkland SA, Kivimaki M, Klein R, Klein BE, Kooperberg C, Kottke-Marchant K, Kumari M, Lacroix AZ, Mallela L, Murugesan G, Ordovas J, Ouwehand WH, Post WS, Saxena R, Scharnagl H, Schreiner PJ, Shah T, Shields DC, Shimbo D, Srinivasan SR, Stolk RP, Swerdlow DI, Taylor HA Jr, Topol EJ, Toskala E, van Pelt JL, van Setten J, Yusuf S, Whittaker JC, Zwinderman AH; LifeLines Cohort Study, Anand SS, Balmforth AJ, Berenson GS, Bezzina CR, Boehm BO, Boerwinkle E, Casas JP, Caulfield MJ, Clarke R, Connell JM, Cruickshanks KJ, Davidson KW, Day IN, de Bakker PI, Doevendans PA, Dominiczak AF, Hall AS, Hartman CA, Hengstenberg C, Hillege HL, Hofker MH, Humphries SE, Jarvik GP, Johnson JA, Kaess BM, Kathiresan S, Koenig W, Lawlor DA, März W, Melander O, Mitchell BD, Montgomery GW, Munroe PB, Murray SS, Newhouse SJ, Onland-Moret NC, Poulter N, Psaty B, Redline S, Rich SS, Rotter JI, Schunkert H, Sever P, Shuldiner AR, Silverstein RL, Stanton A, Thorand B, Trip MD, Tsai MY, van der Harst P, van der Schoot E, van der Schouw YT, Verschuren WM, Watkins H, Wilde AA, Wolffenbuttel BH, Whitfield JB, Hovingh GK, Ballantyne CM, Wijmenga C, Reilly MP, Martin NG, Wilson JG, Rader DJ, Samani NJ, Reiner AP, Hegele RA, Kastelein JJ, Hingorani AD, Talmud PJ, Hakonarson H, Elbers CC, Keating BJ, Drenos F. Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci. Am J Hum Genet. 2012 Oct 10. pii: S0002-9297(12)00474-0. doi: 10.1016/j.ajhg. 2012.08.032. PMID: 23063622
• Joseph P, Pare G, Anand S.  Exploring Gene Environment Interactions in Cardiovascular Disease.  Canadian Journal of Cardiology.  (In Press Oct 2012) 
• Samaan Z, Anand S, Zhang X, Desai D, Rivera M, Pare G, Thabane L, Xie C, Gerstein H, Engert J, McGuffin P, Farmer A, Craig I, Lewis C, Cohen-Woods S, Breen G, Mohan V, Diaz R, Wang X, Liu L, Corre T, Preisig M, Kutalik Z, Bergmann S, Vollenweider P, Weber G, Yusuf S.  The protective effect of the obesity associated rs9939609 A variant in Fat mass and obesity associated gene on depression.  Molecular Psychiatry.  (In Press October 2012) 
• Anand SS. On behalf fo the START Cohrt Study Invesitgators. Rationale and Design of South Asian Birth Cohort (START): A Canada-India Collaborative Study BMC Public Health (In Press Oct 2012)
• Raitakari O, Mäkinen V, McQueen M, Niemi J, Juonala M, Jauhiainen M, Salomaa V, Hannuksela M, Savolainen M, Kesäniemi Y, Kovanen P, Sundvall J, Solakivi T, Loo B, Marniemi J, Hernesniemi J, Lehtimäki T, Kähönen M, Peltonen M, Leiviskä J, Jula A, Anand SS, Miller R, Yusuf S, Viikari J, Ala-Korpela M. Computationally estimated apolipoproteins B and A1 in predicting cardiovascular risk. Atherosclerosis (In Press Oct 2012)

Joseph Beyene

2013 Publications

• Jayalath VH, de Souza RJ, Sievenpiper JL, Ha V, Chiavaroli L, Mirrahimi A, Di Buono M, Bernstein AM, Leiter LA, Kris-Etherton PM,Vuksan V, Beyene J, Kendall CWC and Jenkins DJA. The effect of dietary pulses on blood pressure: a systematic review and meta-analysis of controlled feeding trials. 2013. Am J Hypertens. [Epub ahead of print]. 2013 Sep 7
• Beyene J, Pare G. Statistical genetics a primer for clinicians to the European Heart Journal.   EHJ EURHEART J-D-12-03504R1. European Heart Journal   August 15, 2013.
• Chu R, Mills EJ, Beyene J, Pullenayegum E, Bakanda C, Nachega JB, Devereaux PJ, Thabane L.  Impact of tuberculosis on mortality among HIV-infected patients receiving antiretroviral therapy in Uganda: a prospective cohort analysis.  AIDS Res Ther. 2013 Jul 13;10(1):19. [Epub ahead of print]
• Ding L, Abebe T, Beyene J, Wilke RA, Goldberg A, Woo JG, Martin LJ, Rothenberg ME, Rao M, Khurana, Hershey GK , Chakraborty R, Mersha TB.  Rank based genome wide analysis reveals association of ryanodine receptor-2 gene variants with childhood asthma among human populations.  Human Genomics MS ID 1637263984939446.  2013 Jul 5; 13:608. Doi: 10.1186/1471-2458-13-608.
• Wahi G, Wilson J, Miller R, Anglin R, McDonald S, Morrison KM, Teo KK, Anand SS; ABC investigators.  Aboriginal birth cohort (ABC): a prospective cohort study of early life determinants of adiposity and associated risk factors among Aboriginal people in Canada.  BMC Public Health. 2013 Jun 25;13:608. doi: 10.1186/1471-2458-13-608.
• Price V, Portwine C, Aelcer S, Eithier MC, Gillmeister B, Silva M, Schindera C, Yanofsky R, Mitchell B, Johnston D L, Lewis V, Dix D, Cellot S, Michon B, Bowes L, Stobart K, Brossard J, Beyene J, Sung L Colostridum difficile infection in pediatric acute myleoid leukemia. Pediatric Infectious Disease Journal  PIDJ 212-930R1  2013 Jun;32(6): 610-613
• Perlis N, Zlotta AR, Beyene J, Finelli A, Fleshner NE, Kulkarni GS. Immediate Post-Transurethral Resection of Bladder Tumor Intravesical Chemotherapy Prevents Non-Muscle-invasive Bladder Cancer Recurrences: An Updated Meta-analysis on 2548 Patients and Quality-of-Evidence Review. Eur Urol. 2013 Jun 19. doi:pii: S0302-2838(13)00607-6. 10.1016/j.eururo.2013.06.009. [Epub ahead of print]
• Bueno M, Yamada J, Harrison D, Khan S, Ohlsson A, Adams-Webber T, Beyene J, Stevens B.  A systematic review and meta-analysis of nonsucrose sweet solutions for pain relief in neonates.  Pain Res Manag. 2013 May – Jun 18 (3): 153-61
• Cellot S, Johnston D, Dix D, Ethier MC, Gillmeister B, Mitchell D, Yanofsky R, Lewis V, Portwine C, Price V, Zelcer S, Silva M, Bowes L, Michon B, Stobart K, Brossard J, Beyene J, Sung L.  Infections in pediatric acute promyelocytic leukemia: from the Canadian Infections in Acute Myeloid Leukemia Research Group.  MS Id 1236473762873420 BMC Cancer.   2013 Jun 4: 13(1): 276 [Epub ahead of print]
• Portwine C, Mitchell D, Johnston D, Gillmeister B,  Ethier  MC, Yanofsky R, Dix D,  Cellot S, Lewis V, Price V, Silva M,  Zelcer S,  Bowes L,  Michon B,  Stobart K, Brossard J, Beyene J, Sung L,.  Infectious events prior to chemotherapy initiation in children with acute myeloid leukemia.  PLoS One. 2013 Apr 26;8(4):e61899. doi: 10.1371/journal.pone.0061899. Print 2013.
• Teuffel O, Leibundgut  K, Lehrnbecher T, Alonzo TA, Beyene J, Sung L.  Anthracyclines during induction therapy in acute myeloid leukemia: A systematic review and meta-analysis British Journal of Haematology BJH -2012-01414.R2. Br J Haematol. 2013 Apr;161(2):192-203. doi:  10.1111/bjh.12233. Epub 2013 Feb 8.
• Shaikh F, Brzezinski J, Alexander S, Arzola C, Carvalho JC, Beyene J, Sung L..  Ultrasound imaging for lumbar punctures and epidural catheterizations: a systematic  review and meta-analysis.  BMJ Manuscript ID BMJ.2013 Mar 26:346:f1720.doi:10.1136/bmj.f1720
• Johnston, DL. Lewis V, Yanofsky R, Gillmeister B, Ethier MC, Mitchell D, Cellost S, Dix D, {Portwine C, Price V, Silva M, Zelcer S, Michon B, Bowes L, Stobart K, Brossard J, Beyene J, Sung L.  Invasive Fungal Infections in Pediatric Acute Myeloid Leukemia.  Mycoses. 2013 Feb 26. doi:10.1111/myc.12063
• Roshanov PS, Fernades N Wilczynski JM, Hemens BJ, You JJ, Handler SM, Nieuwlaat R, Souza NM, Beyene J, Spall HG, Garg AX, Haynes RB   Features of effective computerized clinical decision support:  Meta-regression analysis of 162 randomized trials .BMJ.2013 Feb 1:346:1657. Doi: 10.1136/bmj.f657
• Anand SS, Vasudevan A, Gupta M, Morrison K, Kurpad A, Teo KK, Srinvasan K; START Cohort Study Investigators.  Rationale and design of South Asian Birth Cohort (START): a Canada-India-collaborative study.  BMC Public Health. 2013 Jan 28; 13:79 doi: 10:1186/1471-2458-13-79
• Ma, J, Raina, P,  Beyene J. Thabane, L  Comparison of population-averaged and cluster-specific models   for the analysis of cluster randomized trials with missing binary outcomes :  a simulation study.  BMC Medical Research Methodology.  BMC Med Res Methodol. 2013 Jan 23;13:9. doi: 10.1186/1471-2288-13-9.
• Ma J, Raina P, Beyene J, Thabane L.  Comparing the performance of different multiple imputation strategies for missing binary outcomes in cluster randomized trials.  A Simulation Study.  Dove Medical Press ID 35621 Doi: 10.2147/OAMS.S35621 Dec 2012 Volume 2012:2 pgs 93-103.
• Hossain A, Willan A, Beyene J.  An improved method on Wilcoxon rank sum test for gene selection from   microarray experiments.  Communications in Statistics – Simulation and Computation.  .LSSP-2011-0455. Doi: 10.1080/03610918.2012.667479 Date of publication January  2, 2013

2012 Publications

• Burton JM, O';Connor PW, Hohol M, Beyene J.  Oral versus intravenous steroids for treatment of relapses in multiple sclerosis.  Cochrane Data base Syst Rev. 2012 Dec 12:12: CD006921. Doi:  10.1002/14651858. CD006921. Pub3
• Hossain A, Willan A, Beyene J.  A flexible nonparametric approach to find candidate genes associated to disease in microarray experiments.  Journal of Bioinformatics and Computational Biology.  October 23, 2012.
• Hu P, Wang X, Haitsma JJ, Furmil S, Masoom H, Liu M, Imai Y, Slutsky AS, Beyene J, Greenwood CM, Dos Santos C.  Microarray  meta-analysis identifies acute lung injury biomarkers in donor lungs that predict development of primary graft failure in recipients. PLoS One, 2012:7 (10) e45506. dol: 10.1371/journal.pone.0045506. Epub 2012 Oct 12.
• Srinivasjois RM, Shah S, Shah PS: Knowledge Synthesis Group on Determinates of Preterm/LBW Births Biracial couples and adverse birth outcomes:  a systematic review and meta-analysis Acta Obstet Gynecol Scand. 2012 Oct; 91 (10): 1134-46. Doi: 10:1111/j.1600-0412.2012.01501x. Epub 2012 Aug 24. Review.
• Mirrahimi A, de Souza Rj, Chiavaroli L, Sievenpiper JL, Beyene J, Hanley AJ, Augustin LS, DendallCW, Jenkins DJ.  Association of glycemic index and load with coronary heart disease events: a systematic review and meta-analysis of prospective cohorts.  J Am Heartr Assoc. 2012 Oct 1 (5): e000752 doi: 10.1161JAHA. 112000752. Epub 2012 Oct. 25
• Dix D, Cellot S, Price V, Gillmeister B, Ethier MC, Johnston DL, Lewis V, Michon B, Mitchell D, Stobart K, Yanofsky R, Portwine C, Silva M, Bowes L, Zelcer S, Brossard J, Traubici J, Allen U, Beyene J, Sung L.  Association Between Corticosteroids and Infectious Death in Pediatric Acute Myeloid Leukemia: Results from the Canadian Infections in AML Research Group. Clin Infec Dis 2012 Oct. 5 Epub ahead of print.
• Chenglin Ye, Browne G, Grdisa V, Beyene J, Thabane L.  Measuring the degree of integration for an integrated service network.  International Journal for Integrated Care.  Vol. 12 July – September 2012.
• Gagnier JJ, Beyene J, Moher D, Boon H, Bombardier H. Investigating clinical heterogeneity in systematic reviews: A methodologic review of guidance in the literature.. BMC Med Res Methodol. 2012 Jul 30;12(1): 111 [Epub ahead of print] 
• Atenafu EG, Hamid JS, To T, Willan AR, Feldman BM, Beyene J. Bias corrected estimation for intra class correlation coefficient in the balanced one-way random effects model.   BMC Medical Research Methodology. 2012 Jul 30;12(1): 111 [Epub ahead of print] 
• Sievenpiper JL, de Souza RJ, Beyene J, Kendall CW, Jenkins DJ, Carleton AJ, Chiavaroli L, Cozma AI, Ha V, Mirrahimi A, Wang D, Yu ME, Di Buono M, Jenkins AL, Leiter LA, Wolever TM.  Fructose: Where does the truth lie?  J Am Coll Nutr.  2012 Jun;31 (3): 149-51.
• Ethier MC, Science M, Beyene J, Briel M, Lehrnbecher T, Sung L.  Mold-active Compared to Fluconazole Prophylaxis to Prevent Invasive Fungal Diseases in Cancer Patients receiving Chemotherapy or Hematopoietic Stem-Cell Transplantation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.  British Journal of Cancer.  Manuscript:  CL/2011/2233R.  2012 May 8;106:1626-37. Doi: 10.1038/bjc.2012.147. Review
• Neupane B, Loeb M, Anand S, Beyene J.  Meta-analysis of genetic association studies under heterogeneity.  European Society of Human Genetics Journal.  Manuscript #: 751-11-EJHG.  2012 May 30doi:10.1038/ejhg.2012.75 [Epub ahead of print]
• Santaguida P, MacQueen G, Keshavara H, Levine M, Beyene J, Raina P.  Comparative Effectiveness of Treatment for Depression after Unsatisfactory response to SSRIs.  AHRQ Publication No. 12-EHC050-EF April 2012.
• Wang DD, Sievenpiper JL, de Souza RJ, Chiavaroli L, Ha V, Cozma Al, Mirrahimi A, Yu ME, Carleton AJ, DiBuono M, Jenkins AL, Leiter LA, Wolever TWS, Beyene J, Kendall CWC, Jenkins DJA.  Differential effects of fructose feeding on serum uric acid, a systematic review and meta-analysis of controlled feeding trials.  J Nutr.  Manuscript No:  NUTRITION/2011/151951.  J Nutr. 2012 May;142(5): 916-23. Epub 2012 Mar 28. Review.
• Cozma Al, Sievenpiper JL, de Souza RJ, Ha V, Wang DD, Mirrahimi A, Yu ME, Carleton AJ, Di Buono M, Jenkins AL, Leiter LA, Wolever TWS, Beyene J, Kendall CWC, Jenkins DJA.  Meta-Analysis – Effect of Fructose on Glycemic Control in Diabetes:  A Systematic Review and Meta-Analysis of Controlled Feeding Trials.  Diabetes Care Journal.  Manuscript NO:  DC12-0073.  Diabetes Care.  2012 Jul;35(7): 1611-20.
•  Xu K, Usary J, Kousis P, Prat A, Wang D, Adams J, Wang W, Loch A, Deng T, Zhao W, Cardiff R, Yoon K, Gaiano N, Ling V, Beyene J, Zacksenhaus E, Gridley T, Leong W, Guidos C, Perou C, Egan S.  Lunatic Fringe Deficiency Cooperates with the Met/Caveolin Gene Amplicon to Induce Basal-Like Breast Cancer.  Cancer Cell Journal.  Cancer-Cell-D-11-00045R3.  Cancer Cell.  2012 May15;21 (5): 626-41.doi: 10.1016.jccr.2012.03.041 
• Webb BD, Barrera M, Beyene J, Carcao M, Daneman D, Elliott I, Gong GW, Halperin IJ, Lord S, Melville H, Narayanan UG, Ota S, Solomon M, Sung L, Young NL, Zachos M, Feldman BM.  Determinants of quality of life in children with chronic somatic disease:  pilot data from the GapS Questionnaire.   Qaul Life Res. 2012 Mar 30 [Epub ahead of print]
• Friedrich J, Adhikari N, Beyene J.  Ratio of geometric means to analyze continuous outcomes in meta- analysis: comparison to mean differences and ratio of arithmetic means using empiric data and simulation.   Statistics in Medicine. 2012 Jul 30;31(17):1857-86. doi: 10.1002/sim.4501. Epub 2012 Mar 22.
• Manji A, Beyene J, Dupuis L, Phillips R, Lehrnbecher T, Sung L.  Outpatient and Oral Antibiotic Management of Low-Risk Febrile Neutropenia are Effective in Childern – a Systematic Review of Prospective Trials.  Supportive Care in Cancer.  2012 Mar 9.  Epub ahead of print
• Brignardello-Petersen R, Carrasco-Labra A, Araya I, Yanine N, Beyene J, Shah PS.  Is adjuvant laser therapy effective for preventing pain, swelling and trismus after surgical removal of impacted mandibular third molars? - A systematic review and meta-analysis.  Journal of Oral and Maxillofacial Surgery.  2012 Mar 5.  Epub ahead of print
• Hamid JS, Greenwood CM, Beyene J.  Weighted Kernel Fisher Discriminant (wKFD) Analysis for Integrating Heterogeneous Data Computational Statistics and Data Analysis.  Computational Statistics and Data Analysis.  2012 June:56(6):2031-2040. 
• Gagnier JJ, Moher D, Boon H, Bombardier C, Beyene J.  An empirical study using permutation –based resampling in meta-regression.  Syst Rev. 2012 Feb 23;1(1): 18 doi: 10.1186/2046-4053-1-18.
• Sievenpiper JL, Chiavaroli L, de Souza RJ, Mirrahimi A, Cozma Al, Ha V, Wang DD, Yu ME, Carleton AJ, Beyene J, Di Buono M, Jenkins AL, Leiter LA, Wolever TM, Kendall CW, Jenkins DJ.  "Catalytic" doses of fructose may benefit glycaemic control without harming cardiometabolic risk factors:  a small meta-analysis of randomized controlled feeding trials.  Br J Nutr.  2012 Feb 21:1-6.  [Epub ahead of print]. 
• Sievenpiper JL, de Souza RJ, Mirrahimi A, Yu ME, Carleton AJ, Beyene J, Chiavaroli L, Di Buono M, Jenkins AL, Leiter LA, Wolever TM, Kendall CW, Jenkins DJ.  Effect of Fructose on Body Weight in Controlled Feeding Trials:  A Systematic Review and Meta-analysis.  Ann Intern Med.  2012 Feb 21;156(4):291-304. 
• Ha V, Sievenpiper JL, de Souza RJ, Chiavaroli L, Wang DD, Cozma Al, Mirrahimi A, Yu ME, Carleton AJ, Di Buono M, Jenkins AL, Leiter LA, Wolever TM, Beyene J, Kendall CW, Jenkins DJ.  Effect of Fructose on Blood Pressure:  A Systematic Review and Meta-Analysis of Controlled Feeding Trials.  Hypertension.  2012 Apr;59(4):787-95.  Epub 2012 Feb 13. 
• Al-Sukhi E, Milot L, Fruitman M, Beyene J, Victor C, Schmocker S, Brown G, McLeod R, Kennedy E.  Diagnostic accuracy of MRI for assessment of T category, lymph node metastases, and circumferential resection margin involvement in patients with rectal cancer:  a systematic review and meta-analysis.  Annals of Surgical Oncology.  2012 Jan 20.  [Epub ahead of print]. 
• Harel Z, Gilbert C, Wald R, Bell C, Perl J, Juurlink D, Beyene J, Shah PS.  The effect of combination treatment with aliskiren and blockers of the renin-angiotensin system on hyperkalaemia and acute kidney injury:  systematic review and meta-analysis.  BMJ.  2012 Jan 9;344:e42.  doi: 10.1136/bmj.e42.
• Blanco E, Beyene J, Maloney AM, Almeida R, Ethier MC, Winick N, Alexander S, Sung L.  Non-relapse mortality in pediatric acute lymphoblastic leukemia:  a systematic review and meta-analysis.  Leuk Lymphoma.  2012 Jan 3.  Epub ahead of print.
• Sung L, Manji A, Beyene J, Dupuis LL, Alexandre S, Phillips R, Lehrnbecher T.  Fluoroquinolones in Children with Fever and Neutropenia – a Systematic Review of Prospective Trials.  Pediatr Infect Dis J.  2012 May 31 (5) : 431-5. Doi: 10:1097/inf.0b013e318242590e 
• Manji A, Lehrnbecher T, Dupuis LL, Beyene J, Sung L.  A Meta-Analysis of Anti-Pseudomonal Penicillins and Cephalosporins in Pediatric Patients with Fever and Neutropenia.  Pediatr Infect Dis J.  2012 Apr;31 (4):353-8. Doi: 101097/INF.0b013e318242590e

Matthew Lanktree

Highlighted Publications

• Vlasschaert C, McNaughton A, Chong M, Cook E, Hopman W, Kestenbaum B, Robinson-Cohen C, Garland J, Moran S, Paré G, Clase C, Tang M, Levin A, Holden R, Rauh M, Lanktree M. Association of Clonal Hematopoiesis of Indeterminate Potential with Worse Kidney Function and Anemia in Two Cohorts of Patients with Advanced Chronic Kidney Disease. JASN 2022 Oct. doi: 10.1681/ASN.2021060774

David Meyre

2016 Publications

• Reddon H, Guéant JL, Meyre D. The importance of gene-environment interactions in obesity. Clinical Science, 2016 Sep 1;130(18):1571-97.

• Abadi A, Peralta-Romero J, Suarez F, Gomez-Zamudio J, Burguete-Garcia AI, Cruz M, Meyre D. Assessing the Effects of 35 European-derived BMI-associated SNPs in Mexican Children. Obesity, 2016 Sep;24(9):1989-95.

• Ishola AF, Gerstein HC, Engert JC, Mohan V, Diaz R, Yusuf S, Anand SS, Meyre D.  Longitudinal relationships between glycemic status and body mass index in a multiethnic study: evidence from observational and genetic epidemiology. Sci Rep, 2016 Aug 2;6:30744.

• Vashi N, Stryjecki C, Peralta-Romero J, Suarez F, Gomez-Zamudio J, Burguete-Garcia A, Cruz M, Meyre D. Genetic markers of inflammation do not contribute to metabolic traits in Mexican children. PeerJ, 2016 Jun 23;4:e2090.

• Rao S, Yao Y, Zheng C, Ryan J, Mao C, Zhang F, Meyre D, Xu Q. Common variants in CACNA1C and MDD susceptibility: a comprehensive meta-analysis. Am J Med Genet B Neuropsychiatr Genet, 2016 Jun 3.

• Bonnefond A*, Keller R*, Meyre D, Stutzmann F, Thuillier D, Stefanov DG, Froguel P, Horber FF, Kral JG. Eating behavior, low-frequency functional mutations in the melanocortin-4 receptor gene (MC4R) and outcomes of bariatric operations: a six-year prospective study. Diabetes Care, 2016 May 23.

• Sohani ZN, Sarma S, Alyass A, de Souza RJ, Robiou-du-Pont S*, Li A*, Mayhew AJ*, Yazdi F*, Reddon H*, Lamri A*, Stryjecki C*, Ishola A*, Lee YK*, Vashi N*, Anand SS, Meyre D. Empirical evaluation of the Q-Genie tool: a protocol for assessment of effectiveness. BMJ Open, 2016 Jun 9;6(6):e010403.

• Hinney A, Kesselmeier M, Jall S, Volckmar AL, Föcker M, Antel J; GCAN; WTCCC3, Heid IM, Winkler TW; GIANT, Grant SF; EGG, Guo Y, Bergen AW, Kaye W, Berrettini W, Hakonarson H; Price Foundation Collaborative Group; Children’s Hospital of Philadelphia/Price Foundation, Herpertz-Dahlmann B, de Zwaan M, Herzog W, Ehrlich S, Zipfel S, Egberts KM, Adan R, Brandys M, van Elburg A, Boraska Perica V, Franklin CS, Tschöp MH, Zeggini E, Bulik CM, Collier D, Scherag A, Müller TD, Hebebrand J. Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index. Mol Psychiatry, 2016 May 17.

• Sánchez FS, Klunder-Klunder M, Salgado AV, Zamudio JG, Peralta-Romero J, Meyre D, Burguete-García A, Cruz M. APOA5 and APOA1 polymorphisms are associated with triglyceride levels in Mexican children. Pediatric Obesity, 2016 May 12.

• Pigeyre M*, Yazdi FT*, Kaur Y*, Meyre D. Recent progress in genetics, epigenetics and metagenomics unveils the pathophysiology of human obesity. Clinical Science, 2016 Jun 1;130(12):943-86.

• Lamri A*, Bonnefond A*, Meyre D, Balkau B, Froguel P, Roussel R, Marre M, Fumeron F and the D.E.S.I.R. study Group. Interaction between GPR120 p.R270H loss-of-function coding variant and dietary fat intake on incident type 2 diabetes risk in the D.E.S.I.R. study. Nutr Metab Cardiovasc Metab, 2016 Apr 25.

• Stryjecki C, Peralta-Romero J, Alyass A, Karam-Araujo R, Suarez F, Gomez-Zamudio J, Burguete-Garcia A, Cruz M, Meyre D. Association between PPAR-γ2 Pro12Ala genotype and insulin resistance is modified by circulating lipids in Mexican children. Sci Rep, 2016 Apr 14;6:24472.

• Sohani ZN, Anand SS, Robiou-du-Pont S, Morrison KM, McDonald SD, Atkinson SA, Teo KK, Meyre D. Risk alleles in/near ADCY5, ADRA2A, CDKAL1, CDKN2A/B, GRB10, and TCF7L2 elevate plasma glucose levels at birth and in early childhood: results from the FAMILY study. PLOS One, 2016 Apr 6;11(4):e0152107.

• Reddon H, Gerstein HC, Engert JC, Mohan V, Bosch J, Desai D, Bailey SD, Diaz R, Yusuf S, Anand SS, Meyre D. Physical activity and genetic predisposition to obesity in a multiethnic longitudinal study. Sci Rep, 2016 Jan 4; 6:18672.

• Mayhew AJ, de Souza RJ, Meyre D, Anand SS, Mente A. A systematic review and meta-analysis of nut consumption and incident risk of CVD and all-cause mortality. Br J Nutr, 2016 Jan;115(2):212-25

2015 Publications

• Samaan Z*, Lee Y*, Gerstein HC, Engert JC, Bosch J, Mohan V, Diaz R, Yusuf S, Anand SS, Meyre D. Obesity genes and risk of major depression in a multiethnic population. J Clin Psychiatry, 2015, 76(12): e1611-e1618.

• Samaan Z*, Garasia S*, Gerstein HC, Engert JC, Mohan V, Diaz R, Yusuf S, Anand SS, Meyre D. Lack of association between type 2 diabetes and major depression: epidemiologic and genetic evidence in a multiethnic population. Transl Psychiatry, 2015 Aug11; 5:e618.

• Alyass A, Turcotte M, Meyre D. From big data analysis to personalized medicine for all: challenges and opportunities. BMC Medical Genomics, 2015 Jun 27;8(1):33.

• Sohani ZN, Meyre D, de Souza RJ, Joseph PG, Gandhi M, Dennis BB, Norman G, Anand SS. Assessing the quality of published genetic association studies: the Q-Genie Tool. BMC Genetics 2015 May 15;16(1):50.

• Meyre D. Re ‘The association of common variants in PCSK1 with obesity: a huge review and meta-analysis’. Am J Epidemiol, 2015 Apr 19.

• Yazdi FT, Clee SM, Meyre D. Obesity genetics in mouse and human: back and forth, and back again. PeerJ 2015 Mar 24; 3:e856.

• Nead KT, Li A, Wehner MR, Neupane B, Gustafsson S, Butterworth A, Engert JC, Davis AD, Hegele RA, Miller R, den Hoed M, Khaw KT, Kilpeläinen TO, Wareham N, Edwards TL, Hallmans G, Varga TV, Kardia SL, Smith JA, Zhao W, Faul JD, Weir D, Mi J, Xi B, Quinteros SC, Cooper C, Sayer AA, Jameson K, Grøntved A, Fornage M, Sidney S, Hanis CL, Highland HM, Häring HU, Heni M, Lasky-Su J, Weiss ST, Gerhard GS, Still C, Melka MM, Pausova Z, Paus T, Grant SF, Hakonarson H, Price RA, Wang K, Scherag A, Hebebrand J, Hinney A, BioBank Japan, AGEN-BMI, GIANT Consortium, Franks PW, Frayling TM, McCarthy MI, Hirschhorn JN, Loos RJ, Ingelsson E, Gerstein HC, Yusuf S, Beyene J, Anand SS, Meyre D. Contribution of common non-synonymous variants in PCSK1 to body-mass index variation and risk of obesity: a systematic review and meta-analysis with evidence from up to 331,175 individuals. Hum Mol Genet, 2015 Jun 15;24(12):3582-94.

• Robiou-du-Pont S, Li A, Christie S, Sohani Z, Meyre D. Should we have blind faith in bioinformatics software? Illustrations from the SNAP web-based tool. PLOS One, 2015 March 5; 10(3):e0118925.

• Garver WS, de la Torre L, Brennan MC, Luo L, Jelinek D, Castillo JJ, Meyre D, Orlando RA, Heidenreich RA, Rayburn WF. Differntial association of Nieman-Pick C1 gene polymorphisms with maternal prepregnancy overweight and gestational diabetes. J Diabetes Obes, 2015;2(1). 

• Philippe J, Stijnen P, Meyre D, De Graeve F, Thuillier D, Delplanque J, Gyapay G, Sand O, Creemers JW, Froguel P, Bonnefond A. A nonsense mutation in PCSK1 contributes to dominantly inherited human obesity". Int J Obes, 2015 Feb; 39(2): 295-302.

• Alyass A, Almgren P, Akerlund M, Dushoff J, Isomaa B, Nilsson P, Tuomi T, Lyssenko V, Groop L, Meyre D. Modeling of oral glucose tolerance test curve identifies one-hour plasma glucose level as a strong predictor of incident type 2 diabetes: results from two prospective cohort studies. Diabetologia. 2015, Jan; 58(1): 87-97.

2013 Publications

 

• Meyre D, Pare G. Genetic dissection of diabetes: facing the Giant. Diabetes. 2013 Sept 24.
• Hu YJ, Berndt SI, Gustafsson S, Ganna A; Genetic Investigation of ANthropometric Traits (GIANT) Consortium, Hirschhorn J, North KE, Ingelsson E, Lin DY. Meta-analysis of Gene-Level Associations for Rare Variants Based on Single-Variant Statistics. Am J Hum Genet. 2013 Jul 24.
• Wahi G, Wilson J, Miller R, Anglin R, McDonald S, Morrison KM, Teo KK, Anand SS; ABC investigators. Aboriginal birth cohort (ABC): a prospective cohort study of early life determinants of adiposity and associated risk factors among Aboriginal people in Canada. BMC Public Health. 2013 Jun 25;13:608.
• Mente A, Meyre D, Lanktree MB, Heydarpour M, Davis AD, Miller R, Gerstein H, Hegele RA, Yusuf S, Anand SS; for the SHARE and SHARE-AP investigators. Causal relationship between adiponectin and metabolic traits: A Mendelian randomization study in a multiethnic population. PLoS One, 2013 Jun 24.
• Bonnefond A, Raimondo A, Stutzmann F, Ghoussaini M, Ramachandrappa S, Bersten DC, Durand E, Vatin V, Balkau B, Lantieri O, Raverdi V, Pattou F, Van Hul W, Van Gaal L, Peet D, Weill J, Miller JL, Horber F, Goldstone A, Driscoll DJ, Bruning JB, Meyre D, Whitelaw M, Froguel P. Loss-of-function mutations in SIM1 contribute to obesity and Prader-Willi-Like-related features, J Clin Invest, 2013 Jun 17.
• Robiou du Pont S, Yengo L, Vaillant E, Lobbens S, Durand E, Horber F, Lantieri O, Marre M, Balkau B, Froguel P, Meyre D. Common variants near BDNF and SH2B1 show nominal evidence of association with snacking behavior in European populations. J Mol Med, 2013 May 3.
• Anand SS, Meyre D, Pare G, Bailey SD, Xie C, Zhang X, Montpetit A, Desai D, Bosch J, Mohan V, Diaz R, McQueen MJ, Cordell HJ, Keavney B, Yusuf S, Gaudet D, Gerstein H, Engert JC; On behalf of the EpiDREAM Genetics Investigators. Genetic Information and the Prediction of Incident Type 2 Diabetes in a High-Risk Multi-Ethnic Population: The EpiDREAM Genetic Study. Diabetes Care. 2013 Apr 19.
• Berndt SI, Gustafsson S, Mägi R, Ganna A, Wheeler E, Feitosa MF, Justice AE, Monda KL, Croteau-Chonka DC, Day FR, Esko T, Fall T, Ferreira T, Gentilini D, Jackson AU, Luan J, Randall JC, Vedantam S, Willer CJ, Winkler TW, Wood AR, Workalemahu T, Hu YJ, Lee SH, Liang L, Lin DY, Min JL, Neale BM, Thorleifsson G, Yang J, Albrecht E, Amin N, Bragg-Gresham JL, Cadby G, den Heijer M, Eklund N, Fischer K, Goel A, Hottenga JJ, Huffman JE, Jarick I, Johansson A, Johnson T, Kanoni S, Kleber ME, König IR, Kristiansson K, Kutalik Z, Lamina C, Lecoeur C, Li G, Mangino M, McArdle WL, Medina-Gomez C, Müller-Nurasyid M, Ngwa JS, Nolte IM, Paternoster L, Pechlivanis S, Perola M, Peters MJ, Preuss M, Rose LM, Shi J, Shungin D, Smith AV, Strawbridge RJ, Surakka I, Teumer A, Trip MD, Tyrer J, Van Vliet-Ostaptchouk JV, Vandenput L, Waite LL, Zhao JH, Absher D, Asselbergs FW, Atalay M, Attwood AP, Balmforth AJ, Basart H, Beilby J, Bonnycastle LL, Brambilla P, Bruinenberg M, Campbell H, Chasman DI, Chines PS, Collins FS, Connell JM, Cookson WO, de Faire U, de Vegt F, Dei M, Dimitriou M, Edkins S, Estrada K, Evans DM, Farrall M, Ferrario MM, Ferrières J, Franke L, Frau F, Gejman PV, Grallert H, Grönberg H, Gudnason V, Hall AS, Hall P, Hartikainen AL, Hayward C, Heard-Costa NL, Heath AC, Hebebrand J, Homuth G, Hu FB, Hunt SE, Hyppönen E, Iribarren C, Jacobs KB, Jansson JO, Jula A, Kähönen M, Kathiresan S, Kee F, Khaw KT, Kivimäki M, Koenig W, Kraja AT, Kumari M, Kuulasmaa K, Kuusisto J, Laitinen JH, Lakka TA, Langenberg C, Launer LJ, Lind L, Lindström J, Liu J, Liuzzi A, Lokki ML, Lorentzon M, Madden PA, Magnusson PK, Manunta P, Marek D, März W, Leach IM, McKnight B, Medland SE, Mihailov E, Milani L, Montgomery GW, Mooser V, Mühleisen TW, Munroe PB, Musk AW, Narisu N, Navis G, Nicholson G, Nohr EA, Ong KK, Oostra BA, Palmer CN, Palotie A, Peden JF, Pedersen N, Peters A, Polasek O, Pouta A, Pramstaller PP, Prokopenko I, Pütter C, Radhakrishnan A, Raitakari O, Rendon A, Rivadeneira F, Rudan I, Saaristo TE, Sambrook JG, Sanders AR, Sanna S, Saramies J, Schipf S, Schreiber S, Schunkert H, Shin SY, Signorini S, Sinisalo J, Skrobek B, Soranzo N, Stančáková A, Stark K, Stephens JC, Stirrups K, Stolk RP, Stumvoll M, Swift AJ, Theodoraki EV, Thorand B, Tregouet DA, Tremoli E, Van der Klauw MM, van Meurs JB, Vermeulen SH, Viikari J, Virtamo J, Vitart V, Waeber G, Wang Z, Widén E, Wild SH, Willemsen G, Winkelmann BR, Witteman JC, Wolffenbuttel BH, Wong A, Wright AF, Zillikens MC, Amouyel P, Boehm BO, Boerwinkle E, Boomsma DI, Caulfield MJ, Chanock SJ, Cupples LA, Cusi D, Dedoussis GV, Erdmann J, Eriksson JG, Franks PW, Froguel P, Gieger C, Gyllensten U, Hamsten A, Harris TB, Hengstenberg C, Hicks AA, Hingorani A, Hinney A, Hofman A, Hovingh KG, Hveem K, Illig T, Jarvelin MR, Jöckel KH, Keinanen-Kiukaanniemi SM, Kiemeney LA, Kuh D, Laakso M, Lehtimäki T, Levinson DF, Martin NG, Metspalu A, Morris AD, Nieminen MS, Njølstad I, Ohlsson C, Oldehinkel AJ, Ouwehand WH, Palmer LJ, Penninx B, Power C, Province MA, Psaty BM, Qi L, Rauramaa R, Ridker PM, Ripatti S, Salomaa V, Samani NJ, Snieder H, Sørensen TI, Spector TD, Stefansson K, Tönjes A, Tuomilehto J, Uitterlinden AG, Uusitupa M, van der Harst P, Vollenweider P, Wallaschofski H, Wareham NJ, Watkins H, Wichmann HE, Wilson JF, Abecasis GR, Assimes TL, Barroso I, Boehnke M, Borecki IB, Deloukas P, Fox CS, Frayling T, Groop LC, Haritunian T, Heid IM, Hunter D, Kaplan RC, Karpe F, Moffatt MF, Mohlke KL, O'Connell JR, Pawitan Y, Schadt EE, Schlessinger D, Steinthorsdottir V, Strachan DP, Thorsteinsdottir U, van Duijn CM, Visscher PM, Di Blasio AM, Hirschhorn JN, Lindgren CM, Morris AP, Meyre D, Scherag A, McCarthy MI, Speliotes EK, North KE, Loos RJ, Ingelsson E. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet, 2013 Apr 7.
• Walters R, Coin LJM, Ruokonen de Smith AJ, El-Sayed, Moustafa JS, Jacquemont S, Elliott P, Esko T, Hartikainen AL, Laitinen J, Männik K, Martinet D, Meyre D, Nauck M , Schurmann C, Sladek R, Thorleifsson G, Thorsteinsdóttir U, Valsesia A, Waeber G, Zufferey F, Balkau B, Pattou F, Metspalu A, Völzke H, Vollenweider P, Stefansson K, Järvelin MR, Beckmann JS, Froguel P, Blakemore AIF. Rare genomic structural variants in complex disease: lessons from the replication of associations with obesity. PLOS One, Epub 2013 March 12.
• Vimaleswaran KS, Berry DJ, Lu C, Tikkanen E, Pilz S, Hiraki LT, Cooper JD, Dastani Z, Li R, Houston DK, Wood AR, Michaëlsson K, Vandenput L, Zgaga L, Yerges-Armstrong LM, McCarthy MI, Dupuis J, Kaakinen M, Kleber ME, Jameson K, Arden N, Raitakari O, Viikari J, Lohman KK, Ferrucci L, Melhus H, Ingelsson E, Byberg L, Lind L, Lorentzon M, Salomaa V, Campbell H, Dunlop M, Mitchell BD, Herzig KH, Pouta A, Hartikainen AL; Genetic Investigation of Anthropometric Traits-GIANT Consortium, Streeten EA, Theodoratou E, Jula A, Wareham NJ, Ohlsson C, Frayling TM, Kritchevsky SB, Spector TD, Richards JB, Lehtimäki T, Ouwehand WH, Kraft P, Cooper C, März W, Power C, Loos RJ, Wang TJ, Järvelin MR, Whittaker JC, Hingorani AD, Hyppönen E. Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Med. 2013 Feb;10(2):e1001383.
• Mejía-Benítez A, Klünder-Klünder M, Yengo L, Meyre D, Aradillas C, Cruz E, Pérez-Luque E, Malacara JM, Garay ME, Peralta-Romero J, Flores-Huerta S, García-Mena J, Froguel P, Cruz M, Bonnefond A. Analysis of the contribution of FTO, NPC1, ENPP1, NEGR1, GNPDA2 and MC4R genes to obesity in Mexican children. BMC Med Genet. 2013 Feb 1;14(1):21

2012 Publications

• Walters R, Coin LJM, Ruokonen de Smith AJ, El-Sayed, Moustafa JS, Jacquemont S, Elliott P, Esko T, Hartikainen AL, Laitinen J, Männik K, Martinet D, Meyre D, Nauck M , Schurmann C, Sladek R, Thorleifsson G, Thorsteinsdóttir U, Valsesia A, Waeber G, Zufferey F, Balkau B, Pattou F, Metspalu A, Völzke H, Vollenweider P, Stefansson K, Järvelin MR, Beckmann JS, Froguel P, Blakemore AIF. Rare genomic structural variants in complex disease: lessons from the replication of associations with obesity. PLOS One, 2012 in press.
• Morandi A, Meyre D, Lobbens S, Kleinman K, Kaakinen M, Rifas-Shiman SL, Vatin V, Gaget S, Pouta A, Hartikainen AL, Laitinen J, Ruokonen A, Das S, Khan AA, Elliott P, Maffeis C, Gillman MW, Järvelin MR, Froguel P. Estimation of newborn risk for child or adolescent obesity: lessons from longitudinal birth cohorts. PLOS One, 2012 Nov. 28.
• Samaan Z, Anand S, Zhang X, Desai D, Rivera-Sanchez M, Pare G, Thabane L, Xie C, Gerstein H, Engert JC, McGuffin P, Farmer AE, Craig I, Lewis CM, Cohen-Woods S, Breen G, Mohan V, Diaz R, Wang X, Liu L, Corre T, Preisig M, Kutalik Z, Bergmann S, Vollenweider P, Waeber G, Yusuf S, Meyre D. The protective effect of the obesity associated rs9939609 A variant in fat mass and obesity associated gene on depression. Mol Psychiatry, 2012 Nov. 20.
• D. Meyre, P.Froguel. L';obésité dans les gènes? Pour la Science N˚421, 2012 Nov
• D. Meyre, P.Froguel. Eradiquer l';obésité? Pour la Science N˚421, 2012 Nov
• Robiou-du-Pont S, Bonnefond A, Yengo L, Vaillant E, Lobbens S, Durand E, Weill J, Lantieri O, Balkau B, Charpentier G, Marre M, Froguel P, Meyre D. Contribution of 24 obesity associated genetic variants to insulin resistance, pancreatic beta-cell function and type 2 diabetes risk in the French population. Int J Obes, 2012 Oct 23
• Clayden RC, Zaruk A, Meyre D, Thabane L, Samaan Z. The association of attempted suicide with genetic variants in the SLC6A4 and TPH genes depends on the definition of suicidal behavior: a systematic review and meta-analysis. Transl Psychiatry, 2012 Oct 2, 2:e166.
• Moustafa JS, Eleftherohorinou H, de Smith AJ, Andersson-Assarsson JC, Alves AC, Hadjigeorgiou E, Walters RG, Asher JE, Bottolo L, Buxton JL, Sladek R, Meyre  D, Dina C, Visvikis-Siest S, Jacobson P, Sjöström L, Carlsson LM, Walley A, Falchi M, Froguel P, Blakemore AI, Coin LJ. Novel Association Approach for Variable Number Tandem Repeats (VNTRs) Identifies DOCK5 as a Susceptibility Gene for Severe Obesity. Hum Mol Genet, 2012 May 16.
• Fox CS, Liu Y, White CC, Feitosa M, Smith AV, Heard-Costa N, Lohman K; GIANT Consortium; MAGIC Consortium; GLGC Consortium, Johnson AD, Foster MC, Greenawalt  DM, Griffin P, Ding J, Newman AB, Tylavsky F, Miljkovic I, Kritchevsky SB, Launer L, Garcia M, Eiriksdottir G, Carr JJ, Gudnason V, Harris TB, Cupples LA, Borecki IB. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. PLoS Genet. 2012 May;8(5):e1002695. Epub 2012 May 10.
• Li A, Meyre D. Challenges in Reproducibility of Genetic Association Studies: Lessons Learned from the Obesity Field. Int J Obes, 2012 May 15
• Bradfield JP, Taal RH, Timpson NJ, Scherag A, Lecoeur C, Warrington N, Hypponen E, Holst C, Valcarcel B, Thiering E, Salem RM, Schumacher F, Sleiman PM, Zhao J, Berkowitz RI, Santhanakrishnan V, Jarick I, Pennell CE, Evans DM, St. Pourcain B, Mook-Kanamori DO, Hofman A, Rivadeinera F, Uitterlinden AG, van Duijn CM, Cousminer DL, Boomsma DI, Boreham CA, Neville CE, Moreno LA, Dallongeville J, Das S, Ring SM, Kemp JP, Buxton JL, Blakemore AI, Guxens M, Hirschhorn J, Gillman MW, Kreiner-Møller E, Bisgaard H, Gilliland F, Heinrich J, Dunbar C, Wheeler E, Barroso I, O'Rahilly S, Meirhaeghe A, Sørensen TI, Power C, Palmer LJ, Hinney A, Widen E, Farooqi IS, McCarthy MI, Froguel P, Meyre D, Hebebrand J, Jarvelin MR, Jaddoe VW, Smith GD, Hakonarson H, Grant SF for the Early Growth Genetics Consortium. A genome-wide association meta-analysis reveals new childhood obesity loci. Nat Genet 2012 Apr 8.
• Rouskas K, Meyre D, Stutzmann F, Paletas K, Papazoglou D, Vatin V, Marchand M, Kouvatsi A, Froguel P. Loss-Of-Function Mutations in MC4R are very rare in the greek severely obese adult population. Obesity, 2012 Mar. 26.
• Froguel P, Ndiaye NC, Bonnefond A, Bouatia-Naji N, Dechaume A, Siest G, Herbeth B, Falchi M, Bottolo L, Guéant-Rodriguez RM, Lecoeur C, Langlois MR, Labrune Y, Ruokonen A, El Shamieh S, Stathopoulou MG, Morandi A, Maffeis C, Meyre D, Delanghe JR, Jacobson P, Sjöström L, Carlsson LM, Walley A, Elliott P, Jarvelin MR, Dedoussis GV, Visvikis-Siest S. A Genome-Wide Association Study Identifies rs2000999 as a Strong Genetic Determinant of Circulating Haptoglobin Levels. PLoS One, 7(3): 2012 Mar 5.
• Ichimura A, Hirasawa A, Poulain-Godefroy O, Bonnefond A, Hara T, Yengo L, Kimura I, Leloire A, Liu N, Iida K, Choquet H, Besnard P, Lecoeur C, Vivequin S, Ayukawa K, Takeuchi M, Ozawa K, Tauber M, Maffeis C, Morandi A, Buzzetti R, Elliott P, Pouta A, Jarvelin MR, Körner A, Kiess W, Pigeyre M, Caiazzo R, Van Hul W, Van Gaal L, Horber F, Balkau B, Lévy-Marchal C, Rouskas K, Kouvatsi A, Hebebrand J, Hinney A, Scherag A, Pattou F, Meyre D, Koshimizu T, Wolowczuk I, Tsujimoto G, Froguel P. Lipid-sensor GPR120 invalidation leads to obesity in both Mouse and Human. Nature, 2012 Feb 19.
• Meyre D. Is FTO a Type 2 Diabetes Susceptibility Gene? Diabetologia, 2012 Feb 2.
•  Dastani Z, Hivert MF, Timpson N, Perry JR, Yuan X, Scott RA, Henneman P, Heid IM, Kizer JR, Lyytikäinen LP, Fuchsberger C, Tanaka T, Morris AP, Small K, Isaacs A, Beekman M, Coassin S, Lohman K, Qi L, Kanoni S, Pankow JS, Uh HW, Wu Y, Bidulescu A, Rasmussen-Torvik LJ, Greenwood CM, Ladouceur M, Grimsby J, Manning AK, Liu CT, Kooner J, Mooser VE, Vollenweider P, Kapur KA, Chambers J, Wareham NJ, Langenberg C, Frants R, Willems-Vandijk K, Oostra BA, Willems SM, Lamina C, Winkler TW, Psaty BM, Tracy RP, Brody J, Chen I, Viikari J, Kähönen M, Pramstaller PP, Evans DM, St Pourcain B, Sattar N, Wood AR, Bandinelli S, Carlson OD, Egan JM, Böhringer S, van Heemst D, Kedenko L, Kristiansson K, Nuotio ML, Loo BM, Harris T, Garcia M, Kanaya A, Haun M, Klopp N, Wichmann HE, Deloukas P, Katsareli E, Couper DJ, Duncan BB, Kloppenburg M, Adair LS, Borja JB; DIAGRAM+ Consortium; MAGIC Consortium; GLGC Investigators; MuTHER Consortium, Wilson JG, Musani S, Guo X, Johnson T, Semple R, Teslovich TM, Allison MA, Redline S, Buxbaum SG, Mohlke KL, Meulenbelt I, Ballantyne CM, Dedoussis GV, Hu FB, Liu Y, Paulweber B, Spector TD, Slagboom PE, Ferrucci L, Jula A, Perola M, Raitakari O,  Florez JC, Salomaa V, Eriksson JG, Frayling TM, Hicks AA, Lehtimäki T, Smith GD,  Siscovick DS, Kronenberg F, van Duijn C, Loos RJ, Waterworth DM, Meigs JB, Dupuis J, Richards JB, Voight BF, Scott LJ, Steinthorsdottir V, Dina C, Welch RP, Zeggini E, Huth C, Aulchenko YS, Thorleifsson G, McCulloch LJ, Ferreira T, Grallert H, Amin N, Wu G, Willer CJ, Raychaudhuri S, McCarroll SA, Hofmann OM, Segrè AV, van Hoek M, Navarro P, Ardlie K, Balkau B, Benediktsson R, Bennett AJ, Blagieva R, Boerwinkle E, Bonnycastle LL, Boström KB, Bravenboer B, Bumpstead S, Burtt NP, Charpentier G, Chines PS, Cornelis M, Crawford G, Doney AS, Elliott KS, Elliott AL, Erdos MR, Fox CS, Franklin CS, Ganser M, Gieger C, Grarup N, Green T, Griffin S, Groves CJ, Guiducci C, Hadjadj S, Hassanali N, Herder C, Isomaa B, Jackson AU, Johnson PR, Jørgensen T, Kao WH, Kong A, Kraft P, Kuusisto J, Lauritzen T, Li M, Lieverse A, Lindgren CM, Lyssenko V, Marre M, Meitinger T, Midthjell K, Morken MA, Narisu N, Nilsson P, Owen KR, Payne F, Petersen AK, Platou C, Proença C, Prokopenko I, Rathmann W, Rayner NW, Robertson NR, Rocheleau G, Roden M, Sampson MJ, Saxena R, Shields BM, Shrader P, Sigurdsson G, Sparsø T, Strassburger K, Stringham HM, Sun Q, Swift AJ, Thorand B, Tichet J, Tuomi T, van Dam RM, van Haeften TW, van Herpt T, van Vliet-Ostaptchouk JV, Walters GB, Weedon MN, Wijmenga C, Witteman J, Bergman RN, Cauchi S, Collins FS, Gloyn AL, Gyllensten U, Hansen T, Hide WA, Hitman GA, Hofman A, Hunter DJ, Hveem K, Laakso M, Morris AD, Palmer CN, Rudan I, Sijbrands E, Stein LD, Tuomilehto J, Uitterlinden A, Walker M, Watanabe RM, Abecasis GR, Boehm BO, Campbell H, Daly MJ, Hattersley AT, Pedersen O, Barroso I, Groop L, Sladek R, Thorsteinsdottir U, Wilson JF, Illig T, Froguel P, van Duijn CM, Stefansson K, Altshuler D, Boehnke M, McCarthy MI, Soranzo N, Wheeler E, Glazer NL, Bouatia-Naji N, Mägi R, Randall J, Elliott P, Rybin D, Dehghan A, Hottenga JJ, Song K, Goel A, Lajunen T, Doney A, Cavalcanti-Proença C, Kumari M, Timpson NJ, Zabena C, Ingelsson E, An P, O'Connell J, Luan J, Elliott A, McCarroll SA, Roccasecca RM, Pattou F, Sethupathy P, Ariyurek Y, Barter P, Beilby JP, Ben-Shlomo Y, Bergmann S, Bochud M, Bonnefond A, Borch-Johnsen K, Böttcher Y, Brunner E, Bumpstead SJ, Chen YD, Chines P, Clarke R, Coin LJ, Cooper MN, Crisponi L, Day IN, de Geus EJ, Delplanque J, Fedson AC, Fischer-Rosinsky A, Forouhi NG, Franzosi MG, Galan P, Goodarzi MO, Graessler J, Grundy S, Gwilliam R, Hallmans G, Hammond N, Han X, Hartikainen AL,  Hayward C, Heath SC, Hercberg S, Hillman DR, Hingorani AD, Hui J, Hung J, Kaakinen M, Kaprio J, Kesaniemi YA, Kivimaki M, Knight B, Koskinen S, Kovacs P, Kyvik KO, Lathrop GM, Lawlor DA, Le Bacquer O, Lecoeur C, Li Y, Mahley R, Mangino M, Martínez-Larrad MT, McAteer JB, McPherson R, Meisinger C, Melzer D, Meyre D, Mitchell BD, Mukherjee S, Naitza S, Neville MJ, Orrù M, Pakyz R, Paolisso G, Pattaro C, Pearson D, Peden JF, Pedersen NL, Pfeiffer AF, Pichler I, Polasek O, Posthuma D, Potter SC, Pouta A, Province MA, Rayner NW, Rice K, Ripatti S, Rivadeneira F, Rolandsson O, Sandbaek A, Sandhu M, Sanna S, Sayer AA, Scheet P, Seedorf U, Sharp SJ, Shields B, Sigurðsson G, Sijbrands EJ, Silveira A, Simpson L, Singleton A, Smith NL, Sovio U, Swift A, Syddall H, Syvänen AC, Tönjes A, Uitterlinden AG, van Dijk KW, Varma D, Visvikis-Siest S, Vitart V, Vogelzangs N, Waeber G, Wagner PJ, Walley A, Ward KL, Watkins H, Wild SH, Willemsen G, Witteman JC, Yarnell JW, Zelenika D, Zethelius B, Zhai G, Zhao JH, Zillikens MC; DIAGRAM Consortium; GIANT Consortium; Global B Pgen Consortium, Borecki IB, Meneton P, Magnusson PK, Nathan DM, Williams GH, Silander K, Bornstein SR, Schwarz P, Spranger J, Karpe F, Shuldiner AR, Cooper C, Serrano-Ríos M, Lind L, Palmer LJ, Hu FB 1st, Franks PW, Ebrahim S, Marmot M, Kao WH, Pramstaller PP, Wright AF, Stumvoll M, Hamsten A; Procardis Consortium, Buchanan TA, Valle TT, Rotter JI, Penninx BW, Boomsma DI, Cao A, Scuteri A, Schlessinger D, Uda M, Ruokonen A, Jarvelin MR, Peltonen L, Mooser V, Sladek R; MAGIC investigators; GLGC Consortium, Musunuru K, Smith AV, Edmondson AC, Stylianou IM, Koseki M, Pirruccello JP, Chasman DI, Johansen CT, Fouchier SW, Peloso GM, Barbalic M, Ricketts SL, Bis JC, Feitosa MF, Orho-Melander M, Melander O, Li X, Li M, Cho YS, Go MJ, Kim YJ, Lee JY, Park T, Kim K, Sim X, Ong RT, Croteau-Chonka DC, Lange LA, Smith JD, Ziegler A, Zhang W, Zee RY, Whitfield JB, Thompson JR, Surakka I, Spector TD, Smit JH, Sinisalo J, Scott J, Saharinen J, Sabatti C, Rose LM, Roberts R, Rieder M, Parker AN, Pare G, O'Donnell CJ, Nieminen MS, Nickerson DA, Montgomery GW, McArdle W, Masson D, Martin NG, Marroni F, Lucas G, Luben R, Lokki ML, Lettre G, Launer LJ, Lakatta EG, Laaksonen R, Kyvik KO, König IR, Khaw KT, Kaplan LM, Johansson Å, Janssens AC, Igl W, Hovingh GK, Hengstenberg C, Havulinna AS, Hastie ND, Harris TB, Haritunians T, Hall AS, Groop LC, Gonzalez E, Freimer NB, Erdmann J, Ejebe KG, Döring A, Dominiczak AF, Demissie S, Deloukas P, de Faire U, Crawford G, Chen YD, Caulfield MJ, Boekholdt SM, Assimes TL, Quertermous T, Seielstad M, Wong TY, Tai ES, Feranil AB, Kuzawa CW, Taylor HA Jr, Gabriel SB, Holm H, Gudnason V, Krauss RM, Ordovas JM, Munroe PB, Kooner JS, Tall AR, Hegele RA, Kastelein JJ, Schadt EE, Strachan DP, Reilly MP, Samani NJ, Schunkert H, Cupples LA, Sandhu MS, Ridker PM, Rader DJ, Kathiresan S. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet. 2012 Mar;8(3):e1002607. Epub 2012 Mar 29.
•  Palmer ND, McDonough CW, Hicks PJ, Roh BH, Wing MR, An SS, Hester JM, Cooke JN, Bostrom MA, Rudock ME, Talbert ME, Lewis JP; DIAGRAM Consortium; MAGIC Investigators, Ferrara A, Lu L, Ziegler JT, Sale MM, Divers J, Shriner D, Adeyemo A, Rotimi CN, Ng MC, Langefeld CD, Freedman BI, Bowden DW, Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, Welch RP, Zeggini E, Huth C, Aulchenko YS, Thorleifsson G, McCulloch LJ, Ferreira T, Grallert H, Amin N, Wu G, Willer CJ, Raychaudhuri S, McCarroll SA, Langenberg C, Hofmann OM, Dupuis J, Qi L, Segrè AV, van Hoek M, Navarro P, Ardlie K, Balkau B, Benediktsson R, Bennett AJ, Blagieva R, Boerwinkle E, Bonnycastle LL, Boström KB, Bravenboer B, Bumpstead S, Burtt NP, Charpentier G, Chines PS, Cornelis M, Couper DJ, Crawford G, Doney AS, Elliott KS, Elliott AL, Erdos MR, Fox CS, Franklin CS, Ganser M, Gieger C, Grarup N, Green T, Griffin S, Groves CJ, Guiducci C, Hadjadj S, Hassanali N, Herder C, Isomaa B, Jackson AU, Johnson PR, Jørgensen T, Kao WH, Klopp N, Kong A, Kraft P, Kuusisto J, Lauritzen T, Li M, Lieverse A, Lindgren CM, Lyssenko V, Marre M, Meitinger T, Midthjell K, Morken MA, Narisu N, Nilsson P, Owen KR, Payne F, Perry JR, Petersen AK, Platou C, Proença C, Prokopenko I, Rathmann W, Rayner NW, Robertson NR, Rocheleau G, Roden M, Sampson MJ, Saxena R, Shields BM, Shrader P, Sigurdsson G, Sparsø T, Strassburger K, Stringham HM, Sun Q, Swift AJ, Thorand B, Tichet J, Tuomi T, van Dam RM, van Haeften TW, van Herpt T, van Vliet-Ostaptchouk JV, Walters GB, Weedon MN, Wijmenga C, Witteman J, Bergman RN, Cauchi S, Collins FS, Gloyn AL, Gyllensten U, Hansen T, Hide WA, Hitman GA, Hofman A, Hunter DJ, Hveem K, Laakso M, Mohlke KL, Morris AD, Palmer CN, Pramstaller PP, Rudan I, Sijbrands E, Stein LD, Tuomilehto J, Uitterlinden A, Walker M, Wareham NJ, Watanabe RM, Abecasis GR, Boehm BO, Campbell H, Daly MJ, Hattersley AT, Hu FB, Meigs JB, Pankow JS, Pedersen O, Wichmann HE, Barroso I, Florez JC, Frayling TM, Groop L, Sladek R, Thorsteinsdottir U, Wilson JF, Illig T, Froguel P, van Duijn CM, Stefansson K, Altshuler D, Boehnke M, McCarthy MI, Soranzo N, Wheeler E, Glazer NL, Bouatia-Naji N, Mägi R, Randall J, Johnson T, Elliott P, Rybin D, Henneman P, Dehghan A, Hottenga JJ, Song K, Goel A, Egan JM, Lajunen T, Doney A, Kanoni S, Cavalcanti-Proença C, Kumari M, Timpson NJ, Zabena C, Ingelsson E, An P, O'Connell J, Luan J, Elliott A, McCarroll SA, Roccasecca RM, Pattou F, Sethupathy P, Ariyurek Y, Barter P, Beilby JP, Ben-Shlomo Y, Bergmann S, Bochud M, Bonnefond A, Borch-Johnsen K, Böttcher Y, Brunner E, Bumpstead SJ, Chen YD, Chines P, Clarke R, Coin LJ, Cooper MN, Crisponi L, Day IN, de Geus EJ, Delplanque J, Fedson AC, Fischer-Rosinsky A, Forouhi NG, Frants R, Franzosi MG, Galan P, Goodarzi MO, Graessler J, Grundy S, Gwilliam R, Hallmans G, Hammond N, Han X, Hartikainen AL, Hayward C, Heath SC, Hercberg S, Hicks AA, Hillman DR, Hingorani AD, Hui J, Hung J, Jula A, Kaakinen M, Kaprio J, Kesaniemi YA, Kivimaki M, Knight B, Koskinen S, Kovacs P, Kyvik KO, Lathrop GM, Lawlor DA, Le Bacquer O, Lecoeur C, Li Y, Mahley R, Mangino M, Manning AK, Martínez-Larrad MT, McAteer JB, McPherson R, Meisinger C, Melzer D, Meyre D, Mitchell BD, Mukherjee S, Naitza S, Neville MJ, Oostra BA, Orrù M, Pakyz R, Paolisso G, Pattaro C, Pearson D, Peden JF, Pedersen NL, Perola M, Pfeiffer AF, Pichler I, Polasek O, Posthuma D, Potter SC, Pouta A, Province MA, Psaty BM, Rayner NW, Rice K, Ripatti S, Rivadeneira F, Rolandsson O, Sandbaek A, Sandhu M, Sanna S, Sayer AA, Scheet P, Seedorf U, Sharp SJ, Shields B, Sijbrands EJ, Silveira A, Simpson L, Singleton A, Smith NL, Sovio U, Swift A, Syddall H, Syvänen AC, Tanaka T, Tönjes A, Uitterlinden AG, van Dijk KW, Varma D, Visvikis-Siest S, Vitart V, Vogelzangs N, Waeber G, Wagner PJ, Walley A, Ward KL, Watkins H, Wild SH, Willemsen G, Witteman JC, Yarnell JW, Zelenika D, Zethelius B, Zhai G, Zhao JH, Zillikens MC, Borecki IB, Loos RJ, Meneton P, Magnusson PK, Nathan DM, Williams GH, Silander K, Salomaa V, Smith GD, Bornstein SR, Schwarz P, Spranger J, Karpe F, Shuldiner AR, Cooper C, Dedoussis GV, Serrano-Ríos M, Lind L, Palmer LJ, Franks PW, Ebrahim S, Marmot M, Kao WH, Pramstaller PP, Wright AF, Stumvoll M, Hamsten A, Buchanan TA, Valle TT, Rotter JI, Siscovick DS, Penninx BW, Boomsma DI, Deloukas P, Spector TD, Ferrucci L, Cao A, Scuteri A, Schlessinger D, Uda M, Ruokonen A, Jarvelin MR, Waterworth DM, Vollenweider P, Peltonen L, Mooser V, Sladek R. A genome-wide association search for type 2 diabetes genes in African Americans. PLoS One. 2012;7(1):e29202. Epub 2012 Jan 4.

Guillaume Paré

2017 Publications

• Shortt C, Ma J, Clayton N, Sherbino J, Whitlock R, Paré G, Hill SA, McQueen M, Mehta
  SR, Devereaux PJ, Worster A, Kavsak PA. Rule-In and Rule-Out of Myocardial Infarction
  Using Cardiac Troponin and Glycemic Biomarkers in Patients with Symptoms Suggestive of
  Acute Coronary Syndrome. Clin Chem. 2017 Jan;63(1):403-414. PMID: 28062631
• Kofler T, Thériault S, Bossard M, Aeschbacher S, Bernet S, Krisai P, Blum S, Risch M,
  Risch L, Albert C, Paré G, Conen D. Relationships of measured and genetically
  determined height with the cardiac conduction system in healthy adults. Circ Arrhythm
  Electrophysiol. 2017 Jan;10(1). pii: e004735. doi 10.1161/CIRCEP.116.004735. PMID:
  28039282
• Vaucher J, Keating BJ, Lasserre AM, Gan W, Lyall DM, Ward J, Smith DJ, Pell JP, Sattar
  N, Paré G, Holmes MV. Cannabis use and risk of schizophrenia: a Mendelian
  randomization study. Mol Psychiatry. 2017 Jan 24. doi: 10.1038/mp.2016.252 [Epub
  ahead of print] PMID: 28115737
• Bossard M, Thériault S, Aeschbacher S, Schoen T, Kunz S, von Rotz M, Estis J, Todd J,
  Risch M, Mueller C, Risch L, Paré G, Conen D. Factors independently associated with
  cardiac troponin I levels in young and healthy adults from the general population. Clin Res
  Cardiol. 2017 Feb;106(2):96-104. PMID: 27535138
• Paquette M, Chong M, Saavedra YG, Paré G, Dufour R, Baass A. The 9p21. 3 locus and
  Cardiovascular Risk in Familial Hypercholesterolemia. J Clin Lipidology. 2017 Mar-
  Apr;11(2):406-412. PMID: 28502497
• Shortt C, Xie F, Whitlock R, Ma J, Clayton N, Sherbino J, Hill SA, Paré G, McQueen M,
  Mehta SR, Devereaux PJ, Worster A, Kavsak P. Economic Considerations of Early Rule-
  In/Rule-Out Algorithms for the Diagnosis of Myocardial Infarction in the Emergency
  Department Using Cardiac Troponin and Glycemic Biomarkers. Clin Chem. 2017
  Feb;63(2):593-602. PMID: 27811206
• Badin M, Iyer JK, Chong M, Graf L, Rivard GE, Waye JS, Paterson AD, Paré G, Hayward
  CPM. Molecular phenotype and bleeding risks of an inherited platelet disorder in a family
  with a RUNX1 frameshift mutation. Haemophilia. 2017 May;23(3):e204-e213. PMID:
  28181366
• Gerstein HC, Paré G, Hess S, Ford RJ, Sjaarda J, Raman K, McQueen M, Lee SF, Haenel
  H, Steinberg GR, ORIGIN Investigators. Growth differentiation factor 15 as a novel
  biomarker for metformin. Diabetes Care. 2017 Feb;40(2):280-283. PMID: 27974345
• Lanktree MB, Sadikovic B, Waye JS, Levstik A, Lanktree BB, Yudin J, Crowther MA,
  Paré G, Adams PC. Clinical Evaluation of a hemochromatosis next-generation sequencing
  gene panel. Eur J Haematol. 2017 Mar;98(3):228-234. PMID: 27753142
• Toma A, Paré G, Leong DP. Alcohol and cardiovascular disease: how much is too much?
  Curr Atheroscler Rep. 2017 Mar;19(3):13. Doi:10.1007/s11883-017-0647-0. Review.
  PMID: 28210975
• Zielinski L, Bhatt M, Sanger N, Plater C, Worster A, Varenbut M, Daiter J, Paré G, Marsh
  DC, Desai D, MacKillop J, Steiner M, McDermid Vaz, Thabane L, Samaan Z. Association
  between cannabis use and methadone maintenance treatment outcomes: an investigationinto sex differences. Biol Sex Differ. 2017 Mar 30;8:8 doi:10.1186/s13293-017-0130-1.
  PMID: 28367308
• Christie SW, Robiou-du-Pont S, Anand SS, Morrison KM, McDonald SD, Paré G,
  Atkinson SA, Teo KK, Meyre D. Genetic contribution to lipid levels in early life based on
  158 loci validated in adults: the FAMILY study. Sci Rep. 2017 Mar 6;7(1):68. Doi:
  10.1038/s41598-017-00102-1. Epub 2017 Mar 6. PMID: 28250428
• Schenkel LC, Kernohan KD, McBride A, Reina D, Hodge A, Ainsworth PJ, Rodenhiser
  DI, Paré G, Bérubé NG, Skinner C, Boycott KM, Schwartz C, Sadikovic B. Identification
  of epigenetic signature associated with alpha thalassemia/mental retardation X-linked
  syndrome. Epigenetics Chromatin. 2017 Mar 10;10:10. PMID: 28293299
• Naji L, Dennis BB, Bawor M, Varenbut M, Daiter J, Plater C, Paré G, Marsh DC,
  Worster A, Desai D, MacKillop J, Thabane L, Samaan Z. The association between age of
  onset of opioid use and comorbidity among opioid dependent patients receiving methadone
  maintenance therapy. Addict Sci Clin Pract. 2017 Mar 28;12(1):9. doi: 10.1186/s13722-
  017-0074-0. PMID: 28347350
• Malik R, Dau T, Gonik M, Sivakumar A, Deredge DJ, Edeleva EV, Götzfried J, van der
  Laan SW, Pasterkamp G, Beaufort N, Seixas S, Bevan S, Lincz LF, Holliday EG, Burgess
  AI, Rannikmäe K, Minnerup J, Kriebel J, Waldenberger M, Müller-Nurasyid M, Lichtner
  P, Saleheen D; International Stroke Genetics Consortium, Rothwell PM, Levi C, Attia J,
  Sudlow CL, Braun D, Markus HS, Wintrode PL, Berger K, Jenne DE, Dichgans M.
  Common coding variant in SERPINA 1 increases the risk for large artery stroke. Proc Natl
  Acad Sci U S A. 2017 Apr 4;114(14):3613-3618. PMID: 28265093
• Mayosi B, Fish M, Shaboodien G, Mastantuono E, Kraus S, Wieland T, Kotta MC, Chin A,
  Laing N, Ntusi N, Chong M, Horsfall C, Pimstone SN, Gentilini D, Parati G, Strom TM,
  Meitinger T, Paré G, Schwartz PJ, Crotti L. Identification of Cadherin 2 (CDH2)
  mutations in arrhythmogenic right ventricular cardiomyopathy. Circ Cardiovasc Genet.
  2017 Apr;10(2). pii: e001605. doi:101161/CIRCGENETICS.116.001605. PMID:
  28280076
• Paikin JS, Hirsh J, Ginsberg JS, Weitz JI, Chan NC, Whitlock RP, Paré G, Eikelboom JW.
  Once versus twice daily aspirin after coronary bypass surgery: a randomized trial. J
  Thromb Haemost. 2017 May;15(5):889-896. PMID: 28267249
• Paquette M, Chong M, Thériault S, Dufour R, Paré G, Baass A. Polygenic risk score
  predicts prevalence of cardiovascular disease in patients with familial
  hypercholesterolemia. J Clin Lipidol. 2017 May-Jun;11(3):725-732. PMID: 28456682
• Thériault S, Whitlock R, Raman K, Vincent J, Yusuf S, Paré G. Gene expression for the
  identification of prevalent atrial fibrillation. J Am Heart Assoc. 2017 June 30;6(7). pii:
  e006057. DOI: 10.1161/JAHA.117.006057. PMID: 28666990
• Christophersen IE, Rienstra M, Roselli C, Yin X, Geelhoed B, Barnard J, Lin H, Arking
  DE, Smith AV, Albert CM, Chaffin M, Tucker NR, Li M, Klarin D, Bihlmeyer NA, Low
  SK, Weeke PE, Müller-Nurasyid M, Smith JG, Brody JA, Niemeijer MN, Dörr M,
  Trompet S, Huffman J, Gustafsson S, Schurmann C, Kleber ME, Lyytikäinen LP, Seppälä
  I, Malik R, Horimoto ARVR, Perez M, Sinisalo J, Aeschbacher S, Thériault S, Yao J41,
  Radmanesh F, Weiss S, Teumer A, Choi SH, Weng LC, Clauss S, Deo R, Rader DJ, Shah SH, Sun A, Hopewell JC, Debette S, Chauhan G, Yang Q, Worrall BB, Paré G, Kamatani
  Y, Hagemeijer YP, Verweij N, Siland JE, Kubo M, Smith JD, Van Wagoner DR, Bis JC,
  Perz S, Psaty BM , Ridker PM, Magnani JW, Harris TB, Launer LJ, Shoemaker MB,
  Padmanabhan S, Haessler J, Bartz TM, Waldenberger M, Lichtner P, Arendt M, Krieger
  JE, Kähönen M, Risch L, Mansur AJ, Peters A , Smith BH, Lind L, Scott SA, Lu Y,
  Bottinger EB, Hernesniemi J, Lindgren CM, Wong JA, Huang J, Eskola M, Morris AP,
  Ford I, Reiner AP, Delgado G, Chen LY, Chen YI, Sandhu RK, Li M, Boerwinkle E,
  Eisele L, Lannfelt L, Rost N, Anderson CD, Taylor KD, Campbell A, Magnusson PK,
  Porteous D, Hocking LJ, Vlachopoulou E, Pedersen NL, Nikus K, Orho-Melander M,
  Hamsten A, Heeringa J, Denny JC, Kriebel J, Darbar D, Newton-Cheh C, Shaffer C,
  Macfarlane PW, Heilmann-Heimbach S, Almgren P9, Huang PL, Sotoodehnia N, Soliman
  EZ, Uitterlinden AG1, Hofman A, Franco OH, Völker U, Jöckel KH, Sinner MF, Lin HJ,
  Guo X; METASTROKE Consortium of the ISGC; Neurology Working Group of the
  CHARGE Consortium, Dichgans M, Ingelsson E, Kooperberg C, Melander O, Loos RJF,
  Laurikka J, Conen D , Rosand J, van der Harst P, Lokki ML, Kathiresan S, Pereira A,
  Jukema JW, Hayward C, Rotter JI, März W, Lehtimäki T, Stricker BH, Chung MK, Felix
  SB, Gudnason V, Alonso A, Roden DM, Kääb S, Chasman DI, Heckbert SR, Benjamin EJ,
  Tanaka T, Lunetta KL, Lubitz SA, Ellinor PT; AFGen Consortium. Large-scale analyses
  of common and rare variants identify 12 new loci associated with atrial fibrillation. Nat
  Genet. 2017 Jun;49(6):946-953. PMID: 28416818
• Shungin D, Deng WQ, Varga TV, Luan J, Mihailov E, Metspalu A; GIANT Consortium,
  Morris AP, Forouhi NG, Lindgren C, Magnusson PKE, Pedersen NL, Hallmans G, Chu
  AY, Justice AE, Graff M, Winkler TW, Rose LM, Langenberg C, Cupples LA, Ridker PM,
  Wareham NJ, Ong KK, Loos RJF, Chasman DI, Ingelsson E, Kilpeläinen TO, Scott RA,
  Mägi R, Paré G, Franks PW. Ranking and characterization of established BMI and lipid
  associated loci as candidates for gene-environment interactions. PLoS Genet. 2017 Jun
  14;13(6):e1006812. PMID: 28614350
• Gerstein HC, Paré G, McQueen MJ, Lee SF, Hess S. Validation of the ORIGIN
  Cardiovascular Biomarker Panel and the value of adding Troponin I in dysglycemic people.
  J Clin Endocrinol Metab. 2017 Jul 1;102(7):2251-2257. PMID: 28368516
• Lanktree MB, Thériault S, Walsh M, Paré G. HDL cholesterol, LDL cholesterol and
  Triglycerides as Risk Factors for Chronic Kidney Disease: a Mendelian Randomization
  Study. Am J Kidney Dis. 2017 Jul 26. Pii:S0272-6386(17)30791-6.
  Doi:10.1053/j.ajkd.2017.06.011. [Epub ahead of print] PMID: 28754456
• Chong M, O’ Donnell M, Thijs V, Dans A, Lopez-Jaramillo P, Gomez-Arbelaez D, Mondo
  C, Czlonkowska A, Skowronska M, Ovesigharan S, Yusuf S, Paré G. Mendelian genes and
  risk of intercerebral hemorrhage and small-vessel ischemic stroke in sporadic cases.
  Stroke. 2017 Aug;48(8):2263-2265. PMID: 28679849
• Wain LV, Vaez A, Jansen R, Joehanes R, van der Most PJ, Erzurumluoglu AM, O’Reilly
  PF, Cabrera CP, Warren HR, Rose LM, Verwoert GC, Hottenga JJ, Strawbridge RJ, Esko
  T, Arking DE, Hwang SJ, Guo X, Kutalik Z, Trompet S, Shrine N, Teumer A, Ried JS, Bis
  JC, Smith AV, Amin N, Nolte IM, Lyytikäinen LP, Mahajan A, Wareham NJ, Hofer E,
  Joshi PK, Kristiansson K, Traglia M, Havulinna AS, Goel A, Nalls MA, Sõber S, Vuckovic D,
• Luan J, Del Greco M F, Ayers KL, Marrugat J, Ruggiero D, Lopez LM, Niiranen T,
  Enroth S, Jackson AU, Nelson CP, Huffman JE, Zhang W, Marten J, Gandin I, Harris SE,
  Zemunik T, Lu Y, Evangelou E, Shah N, de Borst MH, Mangino M, Prins BP, Campbell
  A, Li-Gao R, Chauhan G, Oldmeadow C, Abecasis G, Abedi M, Barbieri CM, Barnes MR,
  Batini C, Beilby J, Blake T, Boehnke M, Bottinger EP, Braund PS, Brown M, Brumat M,
  Campbell H, Chambers JC, Cocca M, Collins F, Connell J, Cordell HJ, Damman JJ, Davies
  G, de Geus EJ, de Mutsert R, Deelen J, Demirkale Y, Doney ASF, Dörr M, Farrall M,
  Ferreira T, Frånberg M, Gao H, Giedraitis V, Gieger C, Giulianini F, Gow AJ, Hamsten A,
  Harris TB, Hofman A, Holliday EG, Hui J, Jarvelin MR, Johansson Å, Johnson AD,
  Jousilahti P, Jula A, Kähönen M, Kathiresan S, Khaw KT, Kolcic I, Koskinen S,
  Langenberg C, Larson M, Launer LJ, Lehne B, Liewald DCM, Lin L, Lind L, Mach F,
  Mamasoula C, Menni C, Mifsud B, Milaneschi Y, Morgan A, Morris AD, Morrison AC,
  Munson PJ, Nandakumar P, Nguyen QT, Nutile T, Oldehinkel AJ, Oostra BA, Org E,
  Padmanabhan S, Palotie A, Paré G, Pattie A, Penninx BWJH, Poulter N, Pramstaller PP,
  Raitakari OT, Ren M, Rice K, Ridker PM, Riese H, Ripatti S, Robino A, Rotter JI, Rudan
  I, Saba Y, Saint Pierre A, Sala CF, Sarin AP, Schmidt R, Scott R, Seelen MA, Shields DC,
  Siscovick D, Sorice R, Stanton A, Stott DJ, Sundström J, Swertz M, Taylor KD, Thom S,
  Tzoulaki I, Tzourio C, Uitterlinden AG, Völker U, Vollenweider P, Wild S, Willemsen G,
  Wright AF, Yao J, Thériault S, Conen D, Attia J, Sever P, Debette S, Mook-Kanamori DO,
  Zeggini E, Spector TD, van der Harst P, Palmer CNA, Vergnaud AC, Loos RJF, Polasek
  O, Starr JM, Girotto G, Hayward C, Kooner JS, Lindgren CM, Vitart V, Samani NJ,
  Tuomilehto J, Gyllensten U, Knekt P, Deary IJ, Ciullo M, Elosua R, Keavney BD, Hicks
  AA, Scott RA, Gasparini P, Laan M, Liu Y, Watkins H, Hartman CA, Salomaa V, Toniolo
  D, Perola M, Wilson JF, Schmidt H, Zhao JH, Lehtimäki T, van Duijn CM, Gudnason V,
  Psaty BM, Peters A, Rettig R, James A, Jukema JW, Strachan DP, Palmas W, Metspalu A,
  Ingelsson E, Boomsma DI, Franco OH, Bochud M, Newton-Cheh C, Munroe PB, Elliott P,
  Chasman DI, Chakravarti A, Knight J, Morris AP, Levy D, Tobin MD, Snieder H,
  Caulfield MJ, Ehret GB. Novel Blood Pressure Locus and Gene Discovery Using
  Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney.
  Hypertension. 2017 Jul 24. Pii:HYPERTENSIONAHA.117.09438 [Epub ahead of print]
  PMID: 28739976
• Wang, L, Paré G, Rundek T. DNA methylation predicts stroke outcome better: the
  epigenetic clock is ticking. Neurology. 2017 Aug 22;89(8):758-759 PMID: 28733336
• Weng LC, Lunetta KL, Müller-Nurasyid M, Smith AV, Thériault S, Weeke PE, Barnard J,
  Bis JC, Lyytikäinen LP, Kleber ME, Martinsson A, Lin HJ, Rienstra M, Trompet S, Krijthe
  BP, Dörr M, Klarin D, Chasman DI, Sinner MF, Waldenberger M, Launer J, Harrris TB,
  Soliman EZ, Alonso A, Paré G, Teizeira PL, Denny JC, Shoemaker MB, Van Wagoner
  DR, Smith JD, Psaty BM, Sotoodehnia N, Taylor KD, Kähönen M, Nikus K, Delgado GE,
  Melander O, Engström G, Yao J, Guo X, Christophersen IE, Ellinor PT, Geelhoed B,
  Verweij N, Macfarlane P, Ford I, Heeringa J, Franco OH, Uitterlinden AG, Völker U,
  Teumer A, Rose LM, Kääb S, Gudnason V, Arking DE, Conen D, Roden DM, Chung MK,
  Heckbert SR, Benjamin EJ, Lehimäki T, März W, Smith JG, Rotter JI, van der Harst P,
  Jukema JW, Stricker BH, Felix SB, Albert CM, Lubitz SA. Genetic Interactions with Age,
  Sex, Body Mass Index, and Hypertension in Relation to Atrial Fibrillation: The AFGen
  Consortium. Sci Rep. 2017 Sep 12;7(1):11303 doi: 10.1038/s41598-017-09396-7. PMID:
  28900195
• Aref-Eshghi E, Schenkel LC, Lin H, Skinner C, Ainsworth P, Paré G, Rodenhiser D, Schwartz C, Sadikovic B. The defining DNA methylation signature of Kabuki syndrome enables functional assessment of genetic variants of unknown clinical significance. Epigenetics. 2017 Sep 21:1-11 doi: 10.1080/15592294.2017.1381807 [Epub ahead of print]. PMID: 28933623
• Paré G, Mao S, Deng WQ. A machine-learning heuristic to improve gene score prediction of polygenic traits. Sci Rep. 2017 Oct 4;7(1):12665. PMID: 28979001
• Aref-Eshighi E, Schenkel LC, Lin H, Skinner C, Ainsworth P, Paré G, Siu V, Rodenhiser D, Schwartz C, Sadikovic B. Clinical Validation of a Genome-Wide DNA Methylation Assay for Molecular Diagnosis of Imprinting Disorders. J Mol Diagn. 2017 Nov;19(6):848-856. PMID: 28807811
• Thériault S, Lali R, Chong M, Velianou JL, Natarajan MK, Paré G. Polygenic contribution in individuals with early-onset coronary artery disease. Circulation: Cardiovascular Genetics. 2017 Nov. [Accepted]
• Zhao W, Rasheed A, Tikkanen E, Lee JJ, Butterworth AS, Howson JMM, Assimes TL, Chowdhury R, Orho-Melander M, Damrauer S, Small A, Asma S, Imamura M, Yamauch T, Chamber JC, Chen P, Sapkota BR, Shah N, Jabeen S, Surendran P, Lu Y, Zhang W, Imran A, Abbas S, Majeed F, Trindade K, Qamar N, Mallick NH, YaqoobZ, Saghir T, Rizvi SNH, Memon A, Rasheed SZ, Memon FU, Mehmood K, Ahmed N, Qureshi IH, Tanveer-Us-Salam, Iqbal W, Malik U, Mehra N, Kuo JZ, Sheu WH, Guo X, Hsiung CA, Juang JJ, Taylor KD, Hung YJ, Lee WJ, Quertermous T, Lee IT, Hsu CC, Bottinger EP, Ralhan S, Teo YY, Wang TD, Alam DS, Di Angelantonio E, Epstein S, Nielson SF, Nordestgaard BG, Tybjaerg-Hansen A, Young R; CHD Exome+ Consortium, Benn M, Frikke-Schmidt R, Kamstrup PR; EPIC-CVD Consortium; EPIC-Interact Consortium; Michigan Biobank, Jukema JW, Sattar N, Smit R, Chung RH, Liang KW, Anand S, Sanghera DK, Ripatti S, Loos RJF, Kooner JS, Tai ES, Rotter JI, Chen YI, Frossard P, Maeda S, Kadowaki T, Reilly M, Paré G, Melander O, Salomaa V, Rader DJ, Danesh J, Voight BF. Saleheen D. Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease. Nat Genet. 2017 Oct;49(10):1450-1457. PMID: 28869590
• Rannikmae K, Sivakumaran V, Millar H, Malik R, Dave T, Dichgans M, Chong M, Mitchell
  BD, O’Donnell M, Paré G, Radmanesh F, Anderson CD, Rosand J, Seshadri S, Traylor M,
  Worrall BB, Woo D, Sudlow CLM, on behalf of the SiGN, METASTROKE, and ISGC. COL4A2 variants are associated with both lacunar ischemic stroke and deep ICH: collaborative meta-analyses of common genetic variation in six rare familial cerebral small vessel disease genes among 21,500 stroke cases and 40,600 controls. Annals of Neurology. 2017 Nov [Accepted]
• Ross S, Gerstein H, Paré G. The genetic link between diabetes and atherosclerosis. Canadian Journal of Cardiology. 2017 Oct. [In press]

2015 Publications

• Battey TWK, Valant V, Baedorf Kassis S, Kourkoulis C, Lee C, Anderson CD, Falcone GJ, Jimenez-Conde J, Fernandez-Cadenas I, Paré G, Rundek T, James ML, Lemmens R, Lee T-H, Tatlisumak T, Kittner SJ, Lindgren A, Mateen FJ, Berkowitz AL, Holliday EG, Majersik J, Maguire J, Sudlow C, Rosand J; on behalf of the International Stroke Genetics Consortium. Recommendations from the International Stroke Genetics Consortium, Part 2: Biological Sample Collection and Storage. Stroke. 2015 Jan;46(1):285-90. doi: 10.1161/STROKEAHA.114.006851. Epub 2014 Dec 9.  PMID: 25492904
• Lanktree MB, Lanktree BB, Paré G, Waye JS, Sadikovic B, Crowther MA.  Examining the clinical use of hemochromatosis genetic testing.  Can J Gastroenterol Hepatol. 2015 Jan-Feb;29(1):41-5.  PMID: 25706573
• Paikin J, Hirsch J, Ginsberg JS, Weitz JI, Chan NC, Whitlock RP, Paré G, Johnston M, Eikelboom JW.  Multiple daily doses of ASA overcome reduced platelet response to once-daily ASA after CABG: A pilot randomized controlled trial.  J Thromb Haemost.  2015 Mar;13(3):448-56. Doi:10.1111/jth.12832. Epub 2015 Feb 6.2014 Dec 27. doi: 10.1111/jth.12832.  PMID: 25546465
• Liang Y, Hirsch J, Weitz JI, Sloane D, Paré G, Zhu J, Eikelboom JW.  Active Metabolite Concentration of Clopidogrel in Patients Taking Different Doses of Aspirin: Results of the Interaction trial.  J Thromb Haemost.  2015 Mar;13(3):347-52. doi: 10.1111/jth.12829. Epub 2015 Feb 4.   PMID: 25557828
• Ross S, Gerstein HC, Eikelboom J, Anand SS, Yusuf S, Paré G.  Mendelian randomization analysis supports the causal role of dysglycemia and diabetes in the risk of coronary artery disease.  Eur Heart J.  2015 Mar 29. pii: ehv083. [Epub ahead of print]  PMID: 25825043
• Paré G, Asma S, Deng WQ.  Contribution of large region joint associations to complex trait genetics.  PLoS Genetics.  2015 Apr 9;11(4):e1005103. doi: 10.1371/journal.pgen.1005103. eCollection 2015.  PMID: 25856144
• Ross S, Nejat S, Paré G.  Use of genetic data to guide therapy in arterial disease.   J Thromb Haemost.  2015 Mar.  [Accepted for publications]
• Ross S, D';Mello M, Anand SS, Eikelboom J, CARDIoGRAMplusC4D Consortium, Stewart AFR, Samani NJ, Roberts R, Paré G.  The effect of bile acid sequestrants on the risk of cardiovascular events: A Mendelian Randomization analysis. Circ Cardiovasc Genet. 2015.  Published online June 4, 2015, doi:10.1161/CIRCGENETICS.114.000952

2014 Publications

• Joseph PG, Pare G, Ross S, Roberts R, Anand SS.  Pharmacogenetics in Cardiovascular Disease: The Challenge of Moving From Promise to Realization: Concepts Discussed at the Canadian Network and Centre for Trials Internationally Network Conference (CANNeCTIN), June 2009.  Clin Cardiol.  2014 Jan;37(1):48-56.  PMID: 24105892
• Beyene J, Pare G.  Statistical genetics with application to population-based study design: a primer for clinicians.  Eur Heart J. 2014 Feb;35(8):495-500.  PMID: 23956254
• Deng WQ, Asma S, Paré G.  Meta-analysis of SNPs involved in variance heterogeneity using Levene';s test for equal variances.  Eur J Hum Genet. 2014 Mar;22(3):427-30.  PMID: 23921533
• Botto F, Alonso-Coello P, Chan MT, Villar JC, Xavier D, Srinathan S, Guyatt G, Cruz P, Graham M, Wang CY, Berwanger O, Pearse RM, Biccard BM, Abraham V, Malaga G, Hillis GS, Rodseth RN, Cook D, Polanczyk CA, Szczeklik W, Sessler DI, Sheth T, Ackland GL, Leuwer M, Garg AX, Lemanach Y, Pettit S, Heels-Ansdell D, Luratibuse G, Walsh M, Sapsford R, Schünemann HJ, Kurz A, Thomas S, Mrkobrada M, Thabane L, Gerstein H, Paniagua P, Nagele P, Raina P, Yusuf S, Devereaux PJ, Sessler DI, Walsh M, Guyatt G, McQueen MJ, Bhandari M, Cook D, Bosch J, Buckley N, Chow CK, Hillis GS, Halliwell R, Li S, Lee VW, Mooney J, Polanczyk CA, Furtado MV, Berwanger O, Suzumura E, Santucci E, Leite K, Santo JA, Jardim CA, Cavalcanti AB, Guimaraes HP, Jacka MJ, Graham M, McAlister F, McMurtry S, Townsend D, Pannu N, Bagshaw S, Bessissow A, Bhandari M, Duceppe E, Eikelboom J, Ganame J, Hankinson J, Hill S, Jolly S, Lamy A, Ling E, Magloire P, Pare G, Reddy D, Szalay D, Tittley J, Weitz J, Whitlock R, Darvish-Kazim S, Debeer J, Kavsak P, Kearon C, Mizera R, O'Donnell M, McQueen M, Pinthus J, Ribas S, Simunovic M, Tandon V, Vanhelder T, Winemaker M, Gerstein H, McDonald S, O'Bryne P, Patel A, Paul J, Punthakee Z, Raymer K, Salehian O, Spencer F, Walter S, Worster A, Adili A, Clase C, Cook D, Crowther M, Douketis J, Gangji A, Jackson P, Lim W, Lovrics P, Mazzadi S, Orovan W, Rudkowski J, Soth M, Tiboni M, Acedillo R, Garg A, Hildebrand A, Lam N, Macneil D, Mrkobrada M, Roshanov PS, Srinathan SK, Ramsey C, John PS, Thorlacius L, Siddiqui FS, Grocott HP, McKay A, Lee TW, Amadeo R, Funk D, McDonald H, Zacharias J, Villar JC, Cortés OL, Chaparro MS, Vásquez S, Castañeda A, Ferreira S, Coriat P, Monneret D, Goarin JP, Esteve CI, Royer C, Daas G, Chan MT, Choi GY, Gin T, Lit LC, Xavier D, Sigamani A, Faruqui A, Dhanpal R, Almeida S, Cherian J, Furruqh S, Abraham V, Afzal L, George P, Mala S, Schünemann H, Muti P, Vizza E, Wang CY, Ong GS, Mansor M, Tan AS, Shariffuddin II, Vasanthan V, Hashim NH, Undok AW, Ki U, Lai HY, Ahmad WA, Razack AH, Malaga G, Valderrama-Victoria V, Loza-Herrera JD, De Los Angeles Lazo M, Rotta-Rotta A, Szczeklik W, Sokolowska B, Musial J, Gorka J, Iwaszczuk P, Kozka M, Chwala M, Raczek M, Mrowiecki T, Kaczmarek B, Biccard B, Cassimjee H, Gopalan D, Kisten T, Mugabi A, Naidoo P, Naidoo R, Rodseth R, Skinner D, Torborg A, Paniagua P, Urrutia G, Maestre ML, Santaló M, Gonzalez R, Font A, Martínez C, Pelaez X, De Antonio M, Villamor JM, García JA, Ferré MJ, Popova E, Alonso-Coello P, Garutti I, Cruz P, Fernández C, Palencia M, Díaz S, Del Castillo T, Varela A, de Miguel A, Muñoz M, Piñeiro P, Cusati G, Del Barrio M, Membrillo MJ, Orozco D, Reyes F, Sapsford RJ, Barth J, Scott J, Hall A, Howell S, Lobley M, Woods J, Howard S, Fletcher J, Dewhirst N, Williams C, Rushton A, Welters I, Leuwer M, Pearse R, Ackland G, Khan A, Niebrzegowska E, Benton S, Wragg A, Archbold A, Smith A, McAlees E, Ramballi C, Macdonald N, Januszewska M, Stephens R, Reyes A, Paredes LG, Sultan P, Cain D, Whittle J, Del Arroyo AG, Sessler DI, Kurz A, Sun Z, Finnegan PS, Egan C, Honar H, Shahinyan A, Panjasawatwong K, Fu AY, Wang S, Reineks E, Nagele P, Blood J, Kalin M, Gibson D, Wildes T; Vascular events In noncardiac Surgery patIents cOhort evaluatioN (VISION) Writing Group, on behalf of The Vascular events In noncardiac Surgery patIents cOhort evaluatioN (VISION) Investigators; Appendix 1. The Vascular events In noncardiac Surgery patIents cOhort evaluatioN (VISION) Study Investigators Writing Group; Appendix 2. The Vascular events In noncardiac Surgery patIents cOhort evaluatioN Operations Committee; Vascular events In noncardiac Surgery patIents cOhort evaluatioN VISION Study Investigators.  Myocardial Injury after Noncardiac Surgery: A Large, International, Prospective Cohort Study Establishing Diagnostic Criteria, Characteristics, Predictors, and 30-day Outcomes.  Anesthesiology. 2014 Mar;120(3):564-78.  PMID: 24534856.  Citations: 4
• Kilarski LL, Achterberg S, Devan W, Traylor M, Malik R, Lindgren A, Pare G, SharmaP, Slowik A, Thijs VN, Walters M, Worrall BB, Sale M, Algra A, Kappelle J, Wijmenga C,  Norrving B, Sandling J, Ronnblom L, Goris A, Franke A, Sudlow C, Rothwell PM, Levi C, Holliday EG, Fornage M, Psaty B, Gretarsdottir S, Thorsteindottir U, Seshadri S, Mitchell B, Kittner S, Clarke R, Hopewell J, Bis J, Boncoraglio G, Meschia J, Ikram A, Hansen B, Montaner J, Thorleifsson G, Stefanson K, Rosand J, de Bakker PIW, Farrall M, Dichgans M, Markus HS, Bevan S.  Meta-analysis in over 17,900 cases of ischaemic stroke reveals a novel association at 12q24.12.  Neurology.  2014 Aug 19;83(8):678-85. doi: 10.1212/WNL.  PMID: 25031287
• Ross S, Samaan Z, Paré G.  An overview of Pharmacogenetics in Psychotropic Drugs.  Current Psychiatry Reviews.  2014 Mar; Vol. 10, No.2, 2014.
• Bailey SD, Xie C, Paré G, Montpetit A, Mohan V, Yusuf S, Gerstein H, Engert JC, Anand SS on behalf of the EpiDREAM and INTERHEART investigators. Variation at the Dipeptidyl Peptidase IV (DPP4) Locus Influences Apolipoprotein B Levels in South Asians and Exhibits Heterogeneity in Europeans Caused by Body Mass Index.  Diabetologia. 2014 Apr;57(4):738-45.  PMID: 24362726
• Winkler TW, Day FR, Croteau-Chonka DC, Wood AR, Locke AE, Mägi R, Ferreira T, Fall T, Graff M, Justice AE, Luan J, Gustafsson S, Randall JC, Vedantam S, Workalemahu T, Kilpeläinen TO, Scherag A, Esko T, Kutalik Z, Heid IM, Loos RJ; Genetic Investigation of Anthropometric Traits (GIANT) Consortium.  Quality control and conduct of genome-wide association meta-analyses.  Nat Protoc. 2014 May;9(5):1192-212.  PMID: 24762786
• Sadikovic B, Paré G.  Genomics and epigenomics in pediatric oncology and clinical laboratory genetics.  Clin Biochem. 2014 Jun;47(9):731-2.  PMID: 24858242
• H3Africa Consortium.  Research capacity.  Enabling the genomic revolution in Africa.  Science. 20 June 2014;344(6190):1346-8. [DOI:10.1126/science.1251546]  PMID: 24948725
• Cotlarciuc I, Malik R, Holliday EG, Ahmadi KR, Paré G, Psaty BM, Fornage M, Hasan N, Rinne PE, Ikram MA, Markus HS, Rosand J, Mitchell BD, Kittner SJ, Meschia JF, van Meurs JB, Uitterlinden AG, Worrall BB, Dichgans M, Sharma P; on behalf of METASTROKE and the International Stroke Genetics Consortium.  Effect of Genetic Variants Associated with Plasma Homocysteine Levels on Stroke Risk.  Stroke. 2014 Jul;45(7):1920-4.  PMID: 24846872
• Samaan Z, Bawor M, Dennis BB, Plater C, Varenbut M, Daiter J, Worster A, March DC, Tan C, Desai D, Thabane L, Paré G.  Genetic influence on methadone treatment outcomes in patients undergoing methadone maintenance treatment for opioid addiction: a pilot study. Neuropsychiatr Dis Treat. 2014 Aug 19;10:1503-8.  PMID: 25187714
• Bawor M, Dennis BB, Samaan MC, Plater C, Worster A, Varenbut M, Daiter J, Marsh DC, Desai D, Steiner M, Anglin R, Coote M, Paré G, Thabane L, Samaan Z.  Methadone induces testosterone suppression in patients with opioid addiction. Sci Rep. 2014 August 26;4:6189. doi: 10.1038/srep06189.  PMID: 25155550
• Ross S, Eikelboom J, Anand S, Eriksson N, Gerstein H, Mehta S, Connolly S, Rose L, Ridker P, Wallentin L, Chasman D, Yusuf S, Paré G.  Association of Cyclooxygenase-2 genetic variant with cardiovascular disease. Eur Heart J. 2014 Sep 1;35(33):2242-8.  PMID: 24796340.  Citations: 1
• Shiffman D, Pare G, Oberbauer R, Louie JZ, Rowland CM, Devlin JJ, Mann JF, McQueen MJ.  A gene variant in CERS2 is associated with rate of increase in albuminuria in patients with diabetes from ONTARGET and TRANSCEND.  PLOS ONE.  2014 Sep19;9(9):e106631.  Doi: 10.1371/journal.pone.0106631.  PMID: 25238615
• Dennis BB, Samaan MC, Bawor M, Paul J, Plater C, Paré G, Worster A, Varenbut M, Daiter J, Marsh DC, Desai D, Thabane L, Samaan Z.  Evaluation of Clinical and Inflammatory Profile in Opioid Addiction Patients with Comorbid Pain: Results from a Multi-Centre Investigation.  Neuropsychiatr Dis Treat. 2014 November;10:2239-2247. doi: 10.2147/NDT.S72785. eCollection 2014.do.  PMID: 25429222
• D';Mello MJJ, Ross SA, Briel M, Anand SS, Gerstein H, Paré G.  The association between shortened leukocyte telomere length and cardio-metabolic outcomes: a systematic review and meta-analysis.  Circ Cardiovasc Genet. 2014 Nov 18. Pii: CIRCGENETICS.113.000485. [Epub ahead of print]  PMID: 25406241 
• Sohani ZN, Deng WQ, Paré G, Meyre D, Gerstein HC, Anand SS.  Does genetic heterogeneity account for the divergent risk of type 2 diabetes in South Asian and white European populations?  Diabetologia. 2014 Nov;57(11):2270-81.  PMID: 25145545
• Merali Z, Ross S, Paré G. The pharmacogentics of carboxylesterases: CES1 and CES2 genetic variants and their clinical effect.  Drug Metabol Drug Interact. 2014;29(3):143-51. doi: 10.1515/dmdi-2014-0009.  PMID: 24988246.

Selected Publications

* Authors contributed equally

• Ross S, Joseph P, Anand S, Paré G. Promises and Challenges of Pharmacogenetics:  An overview of study design, methodological and statistical issues.  Journal of the Royal Society of Medicine-  Cardiovascular Disease.  [Accepted for publication] Feb. 2012
• Paré G, Ross S, Mehta SR, Yusuf S, Anand SS, Connolly SJ, Fox KAA, Eikelboom JW.  Effect of PON1 Q192R Genetic Polymorphism on Clopidogrel Efficacy and Cardiovascular Events in the Clopidogrel in the Unstable Angina to Prevent Recurrent Events (CURE) Trial and the Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events (ACTIVE). Circ Cardiovasc Genet. 2012 Apr 1;5(2):250-6. Epub 2012 Feb 24.
• Keichl S, Paré G, Barbalic M, Qi L, Dupuis J, Dehghan A, Bis JC, Laxton RC, Xiao Q, Bonora E, Willeit J, Xu Q, Witteman JC, Chasman D, Tracy RP, Ballantyne CM, Ridker PM, Benjamin EJ, Ye S.  Association of variation at the ABO locus with circulating levels of soluble intercellular adhesion molecule-1, soluble P-selectin, and soluble E-selectin: a meta-analysis.  Circ Cardiovasc Genet. 2011 Dec;4(6):681-6. Epub 2011 Oct 18.
• Paré G, Eikelboom JW, Sibbing D, Bernlochner I, Kastrati A.  Testing should not be done in all patients who are undergoing percutaneous coronary intervention.  Circ Cardiovasc Interv. 2011 Oct 1;4(5):514-21.
• Deng W, Paré G. A fast algorithm to optimize SNP prioritization for gene-gene and gene-environment interactions. Genet Epidemiol. 2011 Nov;35(7):729-38. doi: 10.1002/gepi.20624. Epub 2011 Sep 15.
• Paré G, Ridker PM, Rose L, Barbalic M, Dupuis J, Dehghan A, Bis JC, Benjamin EJ, Shiffman D, Parker AN, Chasman DI.  Genome-wide association analysis of soluble ICAM-1 concentration reveals novel associations at the NFKBIK, PNPLA3, RELA and SH2B3 loci.  PLoS Genet. 2011 Apr;7(4):e1001374.
• Paré G, Anand SS. Mendelian randomisation, triglycerides, and CHD. Lancet. 2010 May 8;375(9726):1584-6. (Editorial)
• Paré G, Mehta SR, Yusuf S, Anand SS, Connolly SJ, Hirsh J, Simonsen K, Bhatt DL, Fox KAA, Eikelboom JW. Effects of CYP2C19 Genotype on Outcomes of Clopidogrel Treatment. N Engl J Med. 2010 Oct 28;363(18):1704-14.
• Paré G, Cook NR, Ridker PM, Chasman DI. On the use of variance per genotype as a tool to identify quantitative trait interaction effects: a report from the Women';s Genome Health Study. PLoS Genet. 2010 Jun 17;6(6):e1000981.
• Paré G. Genome-wide association studies-- data generation, storage, interpretation and bioinformatics. J Cardiovasc Transl Res. 2010 Jun;3(3):183-8.
• Paynter NP, Chasman DI, Paré G, Buring JE, Cook NR, Miletich JP, Ridker PM. Association between a literature-based genetic risk score and cardiovascular events in women. JAMA.2010 Feb 17;303(7):631-7.
• Paré G*, Chasman DI*, Parker AN, Zee RR, Malarstig A, Seedorf U, Collins R, Watkins H, Hamsten A, Miletich JP, Ridker PM. Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13 974 participants in the Women's Genome Health Study.Circ Cardiovasc Genet. 2009 Apr;2(2):142-50.
• Danik JS*, Paré G*, Chasman DI, Zee RY, Kwiatkowski DJ, Parker A, Miletich JP, Ridker PM. Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study. Circ Cardiovasc Genet. 2009 Apr;2(2):134-41.
• Paré G*, Chasman DI, Parker AN, Nathan DM, Miletich JP, Zee Ry, Ridker PM. Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study. PLoS Genet. 2008 Dec;4(12):e1000312.
• Chasman DI, Paré G*, Zee RY, Parker AN, Cook NR, Buring JE< Kwiatkowski DJ, Rose LM, Smith JD, Williams PT, Rieder MJ, Rotter JI, Nickerson DA, Krauss RM, Miletich JP, Ridker PM. Genetic loci associated with plasma concentration of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, apolipoprotein A1, and Apolipoprotein B among 6382 white women in genome-wide analysis with replication. Circ Cardiovasc Genet. 2008 Oct;1(1):21-30.
• Paré G*, Chasman DI, Kellogg M, Zee RY, Rifai N, Badola S, Miletich JP, Ridker PM. Novel association of ABO histo-blood group antigen with soluble ICAM-1: results of a genome-wide association study of 6,578 women. PLoS Genet. 2008 Jul 4;4(7):e1000118.
• Paré G*, Serre D, Brisson D, Anand SS, Montpetit A, Tremblay G, Engert JC, Hudson TJ, Gaudet D. Genetic analysis of 103 candidate genes for coronary artery disease and associated phenotypes in a founder population reveals a new association between endothelin-1 and high-density lipoprotein cholesterol. Am J Hum Genet. 2007 Apr;80(4):673-82.

Zena Samaan

2015 Publications

• Dennis BB, Bawor M, Paul J, Varenbut M, Daiter J, Plater C, Pare G, Marsh DC, Worster A, Desai D, Thabane L, Samaan Z. The impact of chronic pain on opioid addiction treatment:  as systematic review protocol.  Syst Rev. 2015 Apr 16;4(1):49. doi: 10.1186/s13643-015-0042-2.
• Perera S, Eisen R, Bawor M, Dennis B, de Souza R, Thabane L, Samaan Z.  Association between body mass index and suicidal behaviors: a systematic review protocol.  Syst Rev 2015 Apr19;4(1):52. doi:10.1186/s13643-015-0038-y.
• Eisen R, Perera S, Bawor M, Banfield L, Anglin R, Minuzzi L, Samaan Z. Association between BDNF levels and suicidal behaviour: a systematic review protocol.  Syst Rev. 2015 Apr 24;4(1):56.
• Bawor M, Bami H, Dennis BB, Plater C, Worster A, Varenbut M, Daiter J, Marsh DC, Steiner M, Anglin R, Coote M, Pare G, Thabane L, Samaan Z.  Testosterone suppression in opioid users: a systematic review and meta-analysis. Drug Alcohol Depend 2015 Apr 1;149: 1-9.  doi: 10:1016/j.drugalcdep.2015.01.0138.

2014 Publications

• Dennis BB, Samaan MC, Bawor M, Paul J, Plater C, Pare G, Worster A, Varenbut M, Daiter J, Marsh DC, Desai D, Thabane L, Samaan Z. Evaluation of clinical and inflammatory profile in opioid addiction patients with comorbid pain: results from a multicenter investigation. Neuropsychiatr Dis Treat. 2014 Nov 19;10:2239-47. doi: 10.2147/NDT.S72785.
• Dennis BB, Naji L, Bawor M, Bonner A, Varenbut M, Daiter J, Plater C, Pare G, Marsh DC, Worster A, Desai D, Samaan Z, Thabane L. The effectiveness of opioid substitution treatments for patients with opioid dependence: a systematic review and multiple treatment comparison protocol. Syst Rev. 2014 Sep 19;3:105. doi: 10.1186/2046-4053-3-105.
• Bawor M, Dennis BB, Samaan MC, Plater C, Worster A, Varenbut M, Daiter J, Marsh DC, Desai D, Steiner M, Anglin R, Coote M, Pare G, Thabane L, Samaan Z. Methadone induces testosterone suppression in patients with opioid addiction. Sci Rep. 2014 Aug 26;4:6189. doi: 10.1038/srep06189.
• Samaan Z, Bawor M, Dennis BB, Plater C, Varenbut M, Daiter J, Worster A, Marsh DC, Tan C, Desai D, Thabane L, Pare G. Genetic influence on methadone treatment outcomes in patients undergoing methadone maintenance treatment for opioid addiction: a pilot study. Neuropsychiatr Dis Treat. 2014 Aug 19;10:1503-8. doi: 10.2147/NDT.S66234.
• Mistry CJ, Bawor M, Desai D, Marsh DC, Samaan Z. Genetics of Opioid Dependence: A Review of the Genetic Contribution to Opioid Dependence. Curr Psychiatry Rev. 2014 May;10(2):156-167.
• Samaan Z, Thabane L. Commentary on 'Elm et al' Clin Trials. 2014 Jul 22;11(4):473-475. [Epub ahead of print] No abstract available. PMID:25053778
• Bawor M, Dennis BB, Anglin R, Steiner M, Thabane L, Samaan Z. Sex differences in outcomes of methadone maintenance treatment for opioid addiction: a systematic review protocol. Syst Rev. 2014 May 16;3(1):45. doi: 10.1186/2046-4053-3-45. PMID: 24887111
• Li G, Mbuagbaw L, Samaan Z, Falavigna M, Zhang S, Adachi JD, Cheng J, Papaioannou A, Thabane L. Efficacy of vitamin D supplementation in depression in adults: a systematic review. J Clin Endocrinol Metab. 2014 Mar;99(3):757-67. doi: 10.1210/jc.2013-3450. Epub 2013 Dec 11. PMID: 24423304
• Monica Bawor, Brittany B. Dennis and Zainab Samaan. Genetics: A Window into the Biology of the Mind. Editorial Current Psychiatry Reviews, 2014, Vol. 10, No. 2 89.
•  Stephanie Ross, Zainab Samaan and Guillaume Pare. An Overview of Pharmacogenetics in Psychotropic Drugs. Current Psychiatry Reviews Volume 10, Number 2, Pp. 182-191 2014
• Dennis BB, Bawor M, Thabane L, Sohani Z, Samaan Z. Impact of ABCB1 and CYP2B6 genetic polymorphisms on methadone metabolism, dose and treatment response in patients with opioid addiction: a systematic review and meta-analysis.PLoS One. 2014 Jan 29;9(1):e86114. doi: 10.1371/journal.pone.0086114.

2013 Publications

• Zainab Samaan, Karleen Schulze, Catherine Middleton, Jane Irvine, Phillip Joseph, Andrew Mente, Guillaume Pare, Baiju R. Shah, Dipika Desai, Sonia S.Anand, for the SAHARA Investigators., "South Asian Heart Risk Assessment (SAHARA): Randomized Trial Design and Pilot Study Results.", JIMR Research Protocols 2013 August PubMed ID:23965279
• Thabane L , Mbuagbaw L , Zhang S , Samaan Z , Marcucci M , Ye C , ThabaneM , Giangregorio L , Dennis B , Kosa D , Borg Debono V , Dillenburg R , FruciV , Bawor M , Lee J , Wells G , Goldsmith CH, "A tutorial on sensitivity analyses in clinical trials: the what, why, when and how.", BMC medical research methodology, 13 2013-07-16 PubMed ID: 23855337
• Samaan Z , Mbuagbaw L , Kosa D , Borg Debono V , Dillenburg R , ZhangS , Fruci V , Dennis B , Bawor M , Thabane L, "A systematic scoping review of adherence to reporting guidelines in health care literature.", Journal of multidisciplinary healthcare, 6 Open Access?: Yes 2013-05-06 PubMed ID: 23671390
• Anglin RE , Samaan Z , Walter SD , McDonald SD, "Vitamin D deficiency and depression in adults: systematic review and meta-analysis.", The British journal of psychiatry : the journal of mental science, 202 2013-02-01 PubMed ID: 23377209

2012 Publications

• Samaan Z , Anand S , Zhang X , Desai D , Rivera M , Pare G , Thabane L ,Xie C , Gerstein H , Engert JC , Craig I Cohen-Woods S , Mohan V , Diaz R ,Wang X , Liu L , Corre T , Preisig M , Kutalik Z , Bergmann S , Vollenweider P,Waeber G , Yusuf S , Meyre D, "The protective effect of the obesity-associated rs9939609 A variant in fat mass- and obesity-associated gene on depression.", Molecular psychiatry 2012-11-20 PubMed ID: 23164817
• Ramasubbu R , Taylor VH , Samaan Z , Sockalingham S , Li M , Patten S ,Rodin G , Schaffer A , Beaulieu S , McIntyre RS ,, "The Canadian Network for Mood and Anxiety Treatments (CANMAT) task force recommendations for the management of patients with mood disorders and select comorbid medical conditions.", Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists, 24(1) 2012-02-01PubMed ID: 22303525
• Samaan Z , Nowacki B , Schulze K , Magloire P , Anand SS, "Smoking cessation intervention in a cardiovascular hospital based clinical setting.", Cardiovascular psychiatry and neurology, 2012 2012-01-01 PubMed ID: 23097692
• Clayden RC , Zaruk A , Meyre D , Thabane L , Samaan Z, "The association of attempted suicide with genetic variants in the SLC6A4 and TPH genes depends on the definition of suicidal behavior: a systematic review and meta-analysis.",Translational psychiatry, 2 2012-01-01 PubMed ID: 23032942
• Sohani ZN , Samaan Z, "Does depression impact cognitive impairment in patients with heart failure?", Cardiology research and practice, 2012 2012-01-01 PubMed ID: 22919538