Faculty of Health SciencesPAUL M. O'BYRNE
CHAIR DEPARTMENT OF MEDICINE
EJ MORAN CAMPBELL PROFESSOR IN RESPIRATORY MEDICINE
Location: HSC 3W10
Telephone: 905 521-2100 x76373
Email address: obyrnep@mcmaster.ca
Education
- MB from University College, Dublin
- Training in Internal Medicine and Respiratory Medicine at McMaster University and the Cardiovascular Research Institute, San Francisco
Research interests
- Mechanisms by which environmental allergens induce airway inflammation and airway hyperresponsiveness
- The pathogenesis of asthma, particularly the role of inflammatory cells, and their trafficking from the bone marrow into the airways
- The mechanisms of airway hyperresponsiveness
- The role of lipid mediators, particularly prostaglandins and the cysteinyl leukotrienes in controlling airway function in normal subjects and asthmatics
Trainees
- Benny Dua, B.Sc.
- Eric Farrell, B.Sc.
- Rei Fujiki, M.D.
Selected Publications
- Boulet LP, O'Byrne PM. Asthma and exercise-induced bronchoconstriction in athletes. N Engl J Med. 2015 Feb 12;372(7):641-8.
- Gauvreau GM, Boulet LP, Leigh R, Cockcroft DW, Killian KJ, Davis BE, Deschesnes F, Watson RM, Swystun V, Mårdh CK, Wessman P, Jorup C, Aurivillius M, O'Byrne PM. A nonsteroidal glucocorticoid receptor agonist inhibits allergen-induced late asthmatic responses. Am J Respir Crit Care Med. 2015 Jan 15;191(2):161-7.
- Gauvreau GM, O'Byrne PM, Boulet LP, Wang Y, Cockcroft D, Bigler J, FitzGerald JM, Boedigheimer M, Davis BE, Dias C, Gorski KS, Smith L, Bautista E, Comeau MR, Leigh R, Parnes JR. Effects of an anti-TSLP antibody on allergen-induced asthmatic responses. N Engl J Med. 2014 May 29;370(22):2102-10.
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O'Byrne PM. Global guidelines for asthma management: summary of the current status and future challenges. Pol Arch Med Wewn. 2010 Dec;120(12) :511-7. Review.
