McMaster University

McMaster University

Gurmit Singh

, PhD

Associate Chair Research and Professor, Pathology and Molecular Medicine

Division: Molecular Medicine

Senior Scientist, Hamilton Health Sciences

2102 Michael G DeGroote Centre for Learning and Discovery
Hamilton, Ontario
905-525-9140 ext. 28144
singhg@mcmaster.ca

 

Faculty Biography

Education and Professional Standing

  • PhD Pharmacology, Dalhousie University, 1982
  • BSc Biochemistry, Dalhousie University, 1977

Interests

General

  • Preclinical drug development in Pain

Specific

  • Peripheral and central mechanisms of cancer-induced bone pain
  • Mechanisms of Neuropathic Pain
  • Role of Cannabinoids in Pain
  • Stress signalling and oxidative stress
  • Mechanisms of cancer-induced depression

Selected Links


Team Members

Research Scientists:

Drs. Katja Linher-Melville and Yong Fang Zhu


Research Assistants

N. Zacal, Manu Sharma


Graduate Students

Robert G. Ungard

 

Selected Publications

  • Linher-Melville K, Sharma M, Nakhla P, Ungard R, Kum E, Park J, Rosa D, Gunning P and Singh G.: Inhibting STAT3 in a Murine model of human breast cancer-induced bone paindelays the onset of nociception. Molecular Pain (2019) 15:1-16.

  • Ungard R, Linher-Melville K, Nashed M, Sharma M, Wen JP and Singh G. xCT knockout inn human breast cancer cells delays onset of cancer-induced bone pain. Molecular Pain (2019) 15:1-14.

  • Zhu YF, Kwiecien J,Ungard R, Zhu Kl, Huzinga J, Henry JL and Singh, G: Cancer pain and neuropathic pain are associated with ABeta sensory neuronal plasticity in dorsal root ganglia and abnormal sprouting in lumbar spinal cord. Molecular Pain (2019) 14:1-14).

  • Young K, Singh G. Biological mechanisms of cancer-induced depression. Frontiers in Psychiatry,    2018;9:1-9.

  • Miladinovic T, Ungard R.G, Linher-Melville K, Popovic S and Singh G. Functional effects of TrkA inhibition on system xc-mediated glutamate release and cancer-induced bone pain. Molecular Pain 2018 14:1-15.

  • Linher-Melville K and Singh G. The complex roles of STAT3 and STAT5 in maintaining redox balance: Lessons from STAT-mediated XCT expression in cancer cells. Molecular and Cellular Endocrinology, 2017, 451: 40-52.

  • Zhu YF, Ungard R, Zacal N, Huizinga J, Henry J, Singh G. A rat model of cancer-induced bone pain: Changes in non-nociceptive sensory neurons in vivo. Pain Reports, 2017 : 2; 1-9.

  • Fazzari J, Balenko, M, Zacal, N, Singh, G. Identification of capsazepine as a novel inhibitor of system xc- and cancer-induced bone pain. Journal of Pain Research, 2017:10, 915-925.

  • Ungard RG, Seidlitz EP, Singh G. Inhibition of breast cancer-cell glutamate release with sulfasalazine limits cancer-induced bone pain. Pain 2014; 155: 28-36.

Books Edited

  • Singh G, editor. Oncodynamics: Effects of Cancer Cells on the Body. 1st ed. Cham: Springer International Publishing, Switzerland; 2016. pp. 1-215 ISBN: 978-3-319-28556-6.

  • Singh G, Rabbani S. Bone Metastasis: Experimental and Clinical Therapeutics. Totowa, N.J.: Humana Press Inc.; 2005.

  • Singh G, Orr FW. Bone Metastasis and Molecular Mechanisms. Dordrecht: Kluwer Academic Publishers; 2004.

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