Education and Professional Standing
- PhD, (Gold Medalist) Medical Sciences, McMaster University, 1995
- MD, University of Western Ontario, 1984
- BSc, Biology, University of Western Ontario, 1980
Research and Clinical Focus
Dr. Hayward’s research laboratory at McMaster University is conducting bench to bedside studies of molecules important to blood clotting and vascular repair. Her group has discovered a new protein, named multimerinl, which functions as an adhesive protein in blood and blood vessels, and as a binding protein for coagulation factor V. They are investigating the formation and functions of platelets and megakaryocytes, including how they are altered by disease. Her group described the first bleeding disorder associated with increased urokinase-type plasminogen activator, a condition known as the Quebec platelet disorder and identified the genetic cause (duplication of the uPA gene) and how it causes bleeding. In conjunction with the Transfusion Research Program at McMaster University, and clinical services in the hospital, they are developing clinical history assessment tools to evaluate bleeding disorders, and are investigating causes of bleeding problems and platelet disorders.
Dr. Hayward is supported by operating grants from the Heart and Stroke Foundation of Canada and the Canadian Institutes of Health Research. She received the 1995 Governor General Gold Medal Award for her PhD studies, the Joe Doupe Young Investigator Award, the Gold Medal in Medicine from the Royal College of Physicians and Surgeons of Canada, the John Charles Polanyi Prize in Physiology and Medicine and was the first Canadian to receive an American Society of Hematology Scholar Award. She has been supported by a Career Investigator Award from the Heart and Stroke Foundation of Ontario, a Canada Research Chair in Molecular Hemostasis, and a Premier’s Research Excellence Award from the Government of Ontario.
Dr. Hayward is the Associate Dean of Graduate Studies (Health Sciences) and is actively involved in the Medical Sciences Graduate Program as a supervisor of graduate students. She also teaches hematology residents and other post-graduate medical students during their coagulation rotation on topics such as bleeding disorders and laboratory tests. She has researched and published on clinician investigator training.
Research Scientist: Dr. Subia Tasneem
Graduate Students: Matthew Badin, Alexander Leatherdale, D'Andra Parker, Asim Soomro
Postdoctoral Fellow: Dr Janak Iyer
Castilloux JF, Moffat KA, Liu Y, Seecharan J, Pai M and Hayward CPM. A Prospective, Cohort Study of Light Transmission Platelet Aggregometry for Bleeding Disorders: Is Testing Native Platelet Rich Plasma Non-Inferior to Testing Platelet Count Adjusted Samples? Thromb Hemost 2011;106(4):675-682.
Hayward CP, Danoff D, Kennedy M, Lee AC, Brzezina S, Bond U. Clinician Investigator Training in Canada: a Review. Clin Invest Med 2011:34(4):E192
A Paterson,JM Rommens,B Bharaj, J Blavignac, I Wong, M Diamandis,
JS Waye, GE Rivard, CPM Hayward. Persons with Quebec platelet disorder have a tandem duplication of PLAU, the urokinase plasminogen activator gene. BLOOD, 2010;115(6):1264-1266.
Hayward CP, Pai M, Liu Y, Moffat KA, Seecharan J, Webert KE, Cook RJ, Heddle NM. Diagnostic utility of light transmission platelet aggregometry: results from a prospective study of individuals referred for bleeding disorder assessments. J Thromb Haemost 2009; 7(4), 676-84.
Tasneem S, Adam F, Minullina I, Pawlikowska M, Hui SK, Zheng S, Miller JL, Hayward CP. Platelet adhesion to multimerin 1 in vitro: influences of platelet membrane receptors, von Willebrand factor and shear. J Thromb Haemost 2009;7(4), 685-92.
Veljkovic DK, Rivard GE, Diamandis M, Blavignac J, Cramer-Borde EM, Hayward CPM. Increased expression of urokinase plasminogen activator in Quebec platelet disorder is linked to megakaryocyte differentiation. Blood 2009;113:1535-42.
Diamandis M, Paterson AD, Rommens JM, Veljkovic DK, Blavignac J, Bulman DE, Waye JS, Derome F, Rivard GE, Hayward CPM. Quebec platelet disorder is linked to the urokinase plasminogen activator gene (PLAU) and increases expression of the linked allele in megakaryocytes. Blood 2009;113:1543-6.
Jeimy SB, Fuller N, Tasneem S, Segers K, Stafford AR, Weitz JI, Camire RM, Nicolaes GAF, Hayward CPM. Multimerin 1 binds factor V and activated factor V with high affinity and inhibits thrombin generation. Thromb Haemost 2008;100:1058-1067.
McKay H, Derome F, Haq MA, Whittaker S, Arnold E, Adam F, Heddle N, Rivard GE, Hayward CPM. Bleeding risks associated with inheritance of the Quebec platelet disorder. Blood 2004;104:159-165.