McMaster University

McMaster University

Laurie Doering

, PhD

Professor
Pathology and Molecular Medicine

Division: Anatomy

Associate Member, McGill University

McMaster University
1R1A Health Sciences Centre
905-525-9140 ext. 22913
doering@mcmaster.ca

 

dr doering

Faculty Biography

Education and Professional Standing

PhD, Anatomy, University of Saskatchewan, 1983
MSc, Anatomy, University of Saskatchewan, 1980
BSc, Anatomy & Microbiology, Queen's University, 1977

Interests

Research Focus

The laboratory studies the cell biology of neural stem cells in normal development and in neurodevelopmental disorders with a current focus on autism and Fragile X syndrome (FXS). Our research uses a knockout mouse model of Fragile X syndrome to study the effect of the affected gene on stem cell lineage biology. A variety of methods are used to evaluate how astrocytes can correct the neuronal phenotype in autism.

Tissue culture, neural stem cells, Fragile X knockout mouse, astrocytes, immunocytochemistry, confocal microscopy and imaging.

Visit our team research grant here


Academic Interests

Dr. Doering is very involved in teaching within the Faculty of Health Sciences. Currently, his academic involvement includes:

Graduate Studies

  • Medical Sciences Program
  • Biochemistry and Biomedical Sciences Program
  • Radiology and Surgery Residency Training

Undergraduate Studies:

  • Education Program in Anatomy
  • Undergraduate Medical Program, Medical Foundations 1,2,3 and 5

Team Members

Graduate Students:
Kathryn Reynolds, Victoria Krasovska

Undergraduate Students:
Amanda Poxon. Kelly Rodrigues, Chloe Wong

Post-doctoral Fellows:
Angela Scott, Shivraj Singh

Selected Publications

Publications:

  • Wang H, Pati S , Pozzo-Miller, L and Doering LC (2015) Neural and synaptic defects in autism spectrum disorders. Front. Cell. Neurosci. 2015 Feb 26;9:55. doi: 10.3389/fncel.2015.00055. eCollection 2015.
  • Wang H and Doering LC (2015) Autism spectrum disorders:emerging mechanisms and mechanism based treatment. Front. Cell. Neurosci. 2015 May 12;9:183. doi: 10.3389/fncel.2015.00183
  • Lai JK, Doering LC and Foster JA (2016) Developmental expression of the neuroligins and neurexins in fragile X mice. J. Comp. Neurol. 2016 Mar 1;524(4):807-28. doi: 10.1002/cne.23868. Epub 2015 Sep 2.
  • Lai JK, Lerch JP, Doering LC, Foster JA and Ellegood J (2016) Regional brain volumes changes in adult male FMR1-KO mouse on the FVB strain. Neuroscience. 2016 Mar 24;318:12-21. doi: 10.1016/j.neuroscience.2016.01.021. Epub 2016 Jan 12
  • Jacobs S, Cheng C and Doering LC (2016) Hippocampal neuronal subtypes develop abnormal dendritic arbors in the presence of Fragile X astrocytes. Neuroscience. 2016 Jun 2;324:202-17. doi: 10.1016/j.neuroscience.2016.03.011. Epub 2016 Mar 8
  • Sourial M and Doering LC (2016) Astrocyte-secreted factors selectively alter neural stem and progenitor proliferation in the Fragile X mouse. Front. Cell. Neurosci. 2016 May 18;10:126. doi: 10.3389/fncel.2016.00126. eCollection 2016.
  • Cheng C, Lau SK and Doering LC (2016) Astrocyte-secreted thrombospondin-1 modulates synapse and spine defects in the fragile X mouse model. Mol. Brain 2016 Aug 2;9(1):74. doi: 10.1186/s13041-016-0256-9.
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