McMaster University

McMaster University

Jacqueline Bourgeois

, MD, MSc

Associate Professor (Part-Time)
Pathology and Molecular Medicine

Cambridge Memorial Hospital
519-621-2330 ext. 2452
jbourgeois@cmh.org

Jacqueline Bourgeois

Faculty Biography

Education and Professional Standing

MD, McMaster University, 1992
MSc, Biology, Plant Physiology, Lakehead University, 1989
BSc, Honours Biochemistry (Biotechnology and Genetic Engineering), McMaster University, 1987

Interests

Research Focus

Dr. Bourgeois’ research interest in metabolic disorders started during her residency while working with Dr. B. Robinson, at The Hospital for Sick Children, Ontario, Canada. Research performed in Dr. Robinson’s on various mitochondrial disorders.  Her interest in improving oncology patient outcomes has translated into a small clinical trial funded by a Hamilton Health Sciences Foundation Grant, examining the potential of creatine supplementation at attenuating the adverse effects and improving the outcome of children treated with corticosteroid for acute lymphoblastic leukemia (ALL). As an extension of these projects she is currently involved in collaborative work with Dr. M. Tarnopolsky.  As a co-investigator, she has provided essential surgical techniques in murine models as well as expertise in histologic examination of the various tissues from these murine models.

Clinical Focus

As a member of the Hamilton Children’s Hospital Dr. Bourgeois has been involved in consultative pediatric pathology. She provides a vital component to the clinical-radiologic-pathologic correlation used in the ultimate management of patients in the pediatric age group. The Children’s Hospital has active Pediatric Surgical and Oncology teams for which Dr. Bourgeois is active participant in the diagnosis of such patients diseases. The hospital has a high risk obstetrical unit, a relatively large neonatal intensive care unit (NICU),  a Maternal Fetal Medicine unit and Prenatal Diagnosis Clinic. These clinical services require Dr. Bourgeois to have expertise in placenta pathology, obstetric, neonatal pathology and developmental pathology.  As part of this practice, she is involved in the examination of such cases and provides vital pathologic information required by the obstetricians, neonatologists and geneticists in the follow-up and genetic counseling of the families for all these services.

Academic Interests

Dr. Bourgeois has been practicing since 1999 and actively supervises the Pediatric Pathology rotation for Anatomic Pathology residents. Rotations have been established for clinical residents and fellows with an interest in perinatal health. During their rotation, the residents are exposed to pediatric oncology, neonatology, placental and embryofetal pathology with an emphasis on the role of the pathologist as a consultant in pediatric oncology, perinatal and placental pathology, and metabolic disorders.


Team Members

Dr. Jorge L. Arredondo, Dr. Jan Jansen

Pathologist Assistants: Janice Kariatsumari, Scott Phillips, Vasco Georgievski

Team members from left to right: Dr. Jorge Arredondo, Dr. Jackie Bourgeois, Scott Phillips, Janice Kariatsumari, Dr. Jan Jansen
Left to right: Dr. Jorge Arredondo, Dr. Jackie Bourgeois, Scott Phillips, Janice Kariatsumari, Dr. Jan Jansen

Selected Publications

  • Li C, Mernagh J, Bourgeois J.Novel craniofacial and extracraniofacial findings in a case of Treacher Collins syndrome with a pathogenic mutation and a missense variant in the TCOF1 gene. Clin Dysmorphol. 2009. 18(1):63-6.
  • Francescutti V, Ellis AK, Bourgeois JM, Ward C Acute acalculous cholecystitis: an unusual presenting feature of Churg-Strauss vasculitis. Can J Surg. 2008. 51(6):E129-30. No abstract available.
  • JM Bourgeois, K Nagel, E Pearce, M Wright, RD Barr, and MA Tarnopolsky. Creatine monohydrate attenuates body fat accumulation in children with acute lymphoblastic leukemia during maintenance chemotherapy.  Pediatric Blood & Cancer. 2008. 51(2):183-7.
  • Mullah-Ali A, Ramsay JA, Bourgeois JM, Hodson I, Macdonald P, Midia M, Portwine C. Paraspinal synovial sarcoma as an unusual postradiation complication in pediatric abdominal neuroblastoma. J Pediatr Hematol Oncol. 2008. 30(7):553-7.
  • Li A a, Bourgeois J, Yoshida L, Potter M, Chang P.  Isolation of human fetal myoblasts and its application for microencapsulation.  J. of Cellular and Mol. Med., 2008. 12(1):271-80.
  • Smith AC, Shuman C, Chitayat D, Steele L, Ray PN, Bourgeois J, Weksberg R.Severe presentation of Beckwith-Wiedemann syndrome associated with high levels of constitutional paternal uniparental disomy for chromosome 11p15.Am J Med Genet A. 2007. 143(24):3010-5.
  • Wen J, Xu N, Li A, Bourgeois J, Ofosu F, Hortelano G.  Encapsulated human primary myoblasts deliver functional hFIX in hemophilic mice.  J. Gene Med., 9(11): 1002-10, 2007.
  • Smith A, Shuman C, Chitayat D, Steele L, Ray P, Bourgeois J, Weksberg R.  Severe presentation of Bechwith-Wiedemann syndrome associated with high levels of constitutional paternal uniparental disomy for chromosome 11p15.  Am. J. Med. Genet. A, in press, November 2007.
  • Wang XY, Zarate N, Soderholm JD, Bourgeois J, Liu LW, Huizinga JD.  Ultrastructural injury to interstitial cells of cajal and communication with mast cells in Crohn’s disease.  Neurogatroenterol Motil., (5): 349-364, 2007.
  • Khan A, Bourgeois J, Mohide P.  Agnathia-otocephaly complex in a fetus with maternal use of topical 1% salicylate. Clin Dysmorphol. 2008. 17(1):75-76.
  • Verdu EF, Mauro M, Bourgeois J, Armstrong D.  Clinical onset of celiac disease after an episode of campylobacter jejunienteritis.  Can. J. Gastroenterol, (7):453-455, 2007
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