McMaster University

McMaster University

Chris Verschoor,

MSc, PhD

Assistant Professor (Part-Time)
Pathology and Molecular Medicine

Research Associate, Canadian Longitudinal Study on Aging

207A McMaster Innovation Park (MIP)
175 Longwood Road South
Hamilton, ON L8P 0A1
Tel: 905-525-9140 x21749
Email: cversch@mcmaster.ca

Website: verschoorlab.ca

Currently accepting applications for prospective undergraduate and graduate students

Dr Verschoor

Faculty Biography

Education and Professional Standing

PDF, 2010-2015. McMaster University. Hamilton, ON, Canada. McMaster Immunology Research Centre. Dept. of Pathology and Molecular Medicine. Focus: Aging and mucosal immunity.

PhD, 2007-2010. University of Guelph. Guelph, ON, Canada. Dept. of Animal and Poultry Science. Focus: Immunogenetics.

MSc, 2004-2006. University of Guelph. Guelph, ON, Canada. Dept. of Animal and Poultry Science. Focus: Genomics.

BSc, 2000-2004. University of Guelph. Guelph, ON, Canada. Biomedical Sciences, Honours.


Interests

Research focus

My ultimate ambition is to better understand immunosenescence and immune dysregulation over the trajectory of aging, and how these changes relate to compromised health and quality of life in old age. This is particularly important since over the next several decades the world will undergo an unprecedented increase in the proportion of adults over the age of 65. Hence, strategies to promote healthy aging will be critical to minimize the social and economic burdens that are normally associated with elder care. Implicit to this goal is a continual advancement of our understanding of the biology of aging. 

My research focus features a comprehensive approach that combines epidemiological techniques to identify inherent and modifiable risk factors of age-related disease and morbidity, and in vitro and ex vivo molecular methods to examine potential biological mechanisms. This approach often features immune and inflammation related soluble and cell-associated biomarkers that not only correlate with aging and/or age-related disease but also modify relevant cellular innate immune processes. I am closely involved with the scientific operations of the Canadian Longitudinal Study on Aging (CLSA, https://www.clsa-elcv.ca/), and largely employ this cohort to test my hypotheses regarding the aging of community-dwelling older adults. I am also interested in the unique immunological alterations that occur to the nursing home elderly, who are often of advanced-age, frail, and feature a number of comorbid conditions.

Specific research interests

  • The identification and examination of biomarkers and other risk factors related to age-related disease and morbidities, such as: frailty, impaired mobility and cognitive impairment. Biomarkers include soluble (serum/plasma cytokines, acute phase proteins, nucleic acids, and other inflammation and immune related molecules) and cell-associated (peripheral blood leukocytes, host genetics and epigenetics (DNA methylation)) factors.
  • Multivariate techniques related to the measurement of biological age and accelerated aging.
  • Myeloid cell dysfunction with age (immunosenescence) and disease. Specifically, the phenotype and innate and anti-bacterial functions of peripheral blood monocytes.
  • High-throughput assay development for the measurement of soluble factors and cellular phenotype in large epidemiological studies such as the Canadian Longitudinal Study on Aging.

Selected Publications

  • Puchta A, Naidoo A, Verschoor CP, Loukov D, Thevaranjan N, Mandur TS, Nguyen P, Jordana M, Loeb M, Xing Z, Kobzik L, Larché MJ, Bowdish and DME. TNF drives monocyte dysfunction with age and results in impaired anti-pneumococcal immunity. 2016. PLOS Pathogens.12(1):e1005368. PMID: 26766566.
  • Verschoor CP, Loukov D, Naidoo A, Puchta A, Johnstone J, Millar J, Lelic A, Novakowski K, Dorrington MG, Loeb M, Bramson JL, and Bowdish DME. Circulating TNF and DNA are major determinants of neutrophil phenotype in the advanced-age, frailty elderly. Molecular Immunology. 2015. 65(1):148-156. PMID: 25660689.
  • Verschoor CP, Johnstone J, Loeb M, Bramson JL, and Bowdish DME. Anti-pneumococcal deficits of monocyte-derived macrophages from the advanced-age, frail elderly and related impairments in PI3K-AKT signaling. Human Immunology. 2014. 75(12):1192-6. PMID: 25446401.
  • Verschoor CP, Dorrington MG, Novakowski KE, Kaiser J, Radford K, Nair P, Anipindi V, Kaushic C, Surette MG and Bowdish DME. MicroRNA-155 is required for the clearance of Streptococcus pneumoniae from the nasopharynx. Infection and Immunity. 2014. 82(11):4824-33. PMID: 25156727.
  • Chu DK, Jimenez-Saiz R, Verschoor CP, Walker TD, Goncharova S, Llop-Guevara A, Shen P, Gordon ME, Barra NG, Bassett JD, Kong J, Fattouh R, McCoy KD, Bowdish DM, Erjefält JS, Pabst O, Humbles AA, Kolbeck R, Waserman S, Jordana M. Indigenous Enteric Eosinophils Control DCs to Initiate a Primary Th2 Immune Response in vivo. Journal of Experimental Medicine. 2014. 211(8):1657-72. PMID: 25071163.
  • Verschoor CP, Johnstone J, Millar J, Parsons R, Lelic A, Loeb M, Bramson JL, and Bowdish DME. Alterations to the frequency and function of peripheral blood monocytes and associations with chronic disease in the advanced-age, frail elderly. PLOS One. 2014. 9(8):e104522. PMID: 25105870.
  • Whelan FJ, Verschoor CP, Stearns J, Rossi L, Johnstone J, Surette MG, and Bowdish DME. The loss of topography in the microbial communities of the upper respiratory tract in the elderly. Annals of the American Thoracic Society . 2014. 11(4):513-21.PMID: 24601676.
  • Verschoor CP, Johnstone J, Millar J, Dorrington MG, Habibagahi M, Lelic A, Loeb M, Bramson JL, and Bowdish DME. Blood CD33(+)HLA-DR(-) myeloid-derived suppressor cells are increased with age and a previous history of cancer. Journal of Leukocyte Biology. 2013. 93(4):633-7. PMID: 23341539.
  • Lelic A, Verschoor CP, Ventresca M, Parsons R, Evelegh C, Bowdish D, Betts MR, Loeb MB, and Bramson JL. The polyfunctionality of memory CD8+ T cells in response to chronic and acute virus infections is not influenced by age. PLoS Pathogens. 2012. 8(12):e1003076. PMID: 23271970.
  • Verschoor CP, Pant SD, You Q, Kelton DF, Karrow NA. Gene expression profiling of PBMCs from Holstein and Jersey cows sub-clinically infected with Mycobacterium avium ssp. paratuberculosis. Veterinary Immunology and Immunopathology. 2010. 137(1-2): 1-11.  PMID: 20447698.
  • Verschoor CP, Pant SD, You Q, Schenkel FS, Kelton DF, Karrow NA. Single nucleotide polymorphisms in the gene encoding bovine interleukin-10 receptor alpha are associated with Mycobacterium avium ssp. paratuberculosis infection status. BMC Genetics. 2010. 11: 23.  PMID: 20398313.
  • Verschoor CP, Pant SD, Schenkel FS, Sharma BS, Karrow NA. SNPs in the bovine IL-10 receptor are associated with somatic cell score in Canadian dairy bulls. Mammalian Genome. 2009. 20:  447-54.  PMID: 19641966.

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