McMaster University

McMaster University

Martin Hyrcza,


Assistant Professor
Pathology and Molecular Medicine

Division: Anatomical Pathology

Consultant Pathologist, Head and Neck, Ophthalmic & Endocrine Pathology

L208-1 St Joseph's Healthcare
Hamilton, Ontario

Tel:   905.522.1155 x35010
Fax:   905.521.6192

photo of Dr Hyrcza

Faculty Biography

Education and Professional Standing

2016-2018 The United States and Canadian Academy of Pathology Ambassador

2015-2016 Combined Endocrine Pathology and Head and Neck Pathology Fellowship at the University of Toronto, Toronto General Hospital, University Health Network

2010–2015 Medical Residency in Anatomic Pathology at the University of British Columbia Faculty of Medicine, Department of Pathology and Laboratory Medicine

2003-2009 PhD in Department of Laboratory Medicine and Pathobiology, University of Toronto.  Thesis: “Gene Expression Changes in Immune Cells During Human Immunodeficiency Virus 1 (HIV-1) Infection” Supervisors: Dr. Sandy D. Der & Dr. Marion A. Ostrowski

2001-2010 MD/PhD Program, University of Toronto

1998-2001 MSc in Molecular Biology, Department of Zoology, University of Toronto,

Thesis:  “Genome-wide screening for genes differentially regulated under heat shock” Supervisor:  Dr. J. Timothy Westwood

1994-1998  BSc (Hon. Molecular Biology Specialist), University of Toronto


Dr Hyrcza is interested in head and neck, ophthalmic, and endocrine pathology. Specific interests include:

  • Histomorphological correlates of molecular changes in tissues
  • Transcription factor markers of squamous differentiation
  • Molecular changes in salivary gland tumours
  • Thymic disorders
  • Competency assessment in pathology education
  • History of pathology

Selected Publications

  • Mutational signatures in oral cancer indicate a complex role for tobacco smoke carcinogens. Grace Bradley, Marco A. Magalhaes, Martin Hyrcza, Oral Diseases, 2017 epub Mar 13

  • Pituitary adenomas presenting as sinonasal or nasopharyngeal masses – a case series illustrating potential diagnostic pitfall. Martin D. Hyrcza, Shereen Ezzat, Ozgur Mete, Sylvia L. Asa; American Journal of Surgical Pathology, 2017, Vol.41(4), pp.525-534

  • BAP1: gene of the month. Ami Wang, Anjali Papneja, Martin D. Hyrcza, Ayman Al Habeeb, Danny Ghazarian, Journal of Clinical Pathology, 2016, Vol.69(9), pp.750-3

  • TFE3-expressing perivascular epithelioid cell neoplasm (pecoma) of the sella. Martin D. Hyrcza, Daniel A. Winer, Mary Shago, Karolyn Au, Gelareh Zadeh, Sylvia L. Asa, Ozgur Mete, Endocrine Pathology, 2017 Vol. 28(1), pp.22-2
  • Proximal epithelioid sarcoma following a history of malignant melanoma - a diagnostic challenge. Gang Wang, Martin D. Hyrcza, Nicholas van der Westhuizen, Torsten Nielsen, Davide Salina Cytopathology, epub May 18, 2016
  • Renal clear cell carcinoma metastasis to salivary glands -a series of 9 cases: clinicopathological study. Hanna Majewska, Alena Skálová, Klaudia Radecka, Dominik Stodulski, Martin Hyrcza, Czesław Stankiewicz, Wojciech Biernat, Polish Journal of Pathology, 2016 Vol. 67(1), pp. 39-45
  • Detection of the ETV6-NTRK3 translocation in cutaneous mammary-analog secretory carcinoma. Martin D. Hyrcza, Tony Ng, Richard I. Crawford, Diagnostic Histopathology, 2015. Vol. 21(12), pp. 481-483
  • Parathyroid lipoadenoma: a clinicopathological diagnosis and possible trap for the unaware pathologist. Martin D. Hyrcza, Pinar Sargin, Ozgur Mete, Endocrine Pathology, 2016 Vol. 27(1), pp. 34-41
  • Mucoepidermoid carcinoma ex-inverted papilloma. Martin D. Hyrcza, Ralph W. Gilbert, Eugene Yu, Bayardo Perez-Ordoñez, Diagnostic Histopathology, 2015 Vol. 21(5) pp.212-215
  • Clear cell myoepithelial carcinoma of salivary glands showing EWSR1 rearrangement: molecular analysis of 93 CASES. Alena Skalova, Ilan Weinreb, Martin Hyrcza, Roderick HW Simpson, Jan Laco, Abbas Agaimy, Marina Vazmitel, Hanna Majewska, Tomas Vanecek, Peter Talarcik, Spomenka Manajlovic, Simona Nunzia Losito, Petr Steiner, Michal Michal, American Journal of  Surgical Pathology 2015 Vol. 39(3) pp.338-348
  • Papillary variant of medullary thyroid carcinoma with cystic change. Martin D. Hyrcza, Dan Winer, Ozgur Mete,  Endocrine Pathology 2015 Vol. 26(1) pp.87-89
  • Low grade intraductal carcinoma of the lacrimal gland. Lulu L. Bursztyn, Martin D. Hyrcza, Larry H. Allen, Ken W. Berean, Bret Wehrli, Orbit, 2014, Volume 33(2) pp.135-8
  • HIV delays IFN-Α production from human plasmacytoid dendritic cells and is associated with SYK phosphorylation. Calvin C. Lo, J.A. Schwartz, D.J. Johnson, M. Yu, N. Aidarus, S. Mujib, E. Benko, Martin Hyrcza, C. Kovacs, M. Ostrowski, 2012, PLoS One.  Vol. 7 (5) e37052
  • Immune activation and neuropsychiatric symptoms in HIV infection. Erin M. Warriner, Sean B. Rourke, Byron P. Rourke,  Sarah Rubenstein, Colleen Millikin, Lori Buchanan, Phil Connelly, Martin Hyrcza, Mario Ostrowski, Sandy Der, Kevin Gough, The Journal of Neuropsychiatry and Clinical Neurosciences, 2010, Vol. 22, pp. 321-8.
  • The impact of CCL3L1 copy number in an HIV-1-infected white population. Elisabeth Y. Lee, F. Y. Yue, R. Bradley Jones, Calvin Lo, Prameet Sheth, Martin D. Hyrcza, Colin Kovacs, E. Benko, Rupert Kaul, Mario Ostrowski , AIDS, 2010, Vol. 24, pp.1589-91
  • TIM-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection. R.B. Jones, Ndhlovu L.C., Barbour J.D., Sheth P.M., Jha A.R, Long B.R., Wong J.C., Satkunarajah M., Schweneker M., Chapman J.M., Gyenes G., Vali B., Martin D. Hyrcza, Yue F.Y., Kovacs C., Sassi A., Loutfy M., Halpenny R., Persad D., Spotts G., Hecht F.M., Chun T.W., McCune J.M., Kaul R., Rini J.M., Nixon D.F., Mario Ostrowski , Journal of Experimental Medicine, 2008, Vol. 205 (12): pp.2763-79
  • Distinct transcriptional profiles in ex vivo CD4+ and CD8+ T cells are established early in HIV infection and are characterized by chronic interferon response as well as extensive transcriptional changes in CD8+ T-cells. Martin D. Hyrcza, Colin Kovacs, Mona Loutfy, Roberta Halpenny, Lawrence Heisler, Stuart Yang, Olivia Wilkins, Mario Ostrowski, Sandy D. Der, Journal of Virology, 2007, Vol. 81 (7): pp.3477-86
  • Genomic DNA functions as a universal external standard in quantitative real-time PCR.  James Yun, Lawrence Heisler, Irene Hwang, Olivia Wilkins, Lau S.K., Martin Hyrcza, Jayabalasingham B., Jin J., McLaurin J., Tsao M.S., Sandy D. Der, Nucleic Acids Research, 2006, Vol. 34(12), e85
Valid XHTML 1.0 Transitional Level Double-A conformance, W3C WAI Web Content Accessibility Guidelines 2.0