McMaster University

McMaster T-cell Epitope
Centre (MTEC)

Scope of Search

Clinical Trials

sneeze

 

PROJECT 1 RECRUITMENT IS NOW CLOSED!

WE ARE STILL RECRUITING FOR PROJECT 2!!!

Contact us for information at

catallergy@sjoes.ca or

905-522-1155 x35296


 

MTEC Cat Allergy Database:

This database will be used to collect contact information on subjects who wish to be considered for current and future clinical studies within our group.

For information please contact Recruitment at MTEC:

Phone: 905-522-1155 ext 35296
Email: catallergy@stjoes.ca

See our ad now appearing on HSR public transit!

Hamilton city bus with cat allergy advertisement on back cat allergy advertisement

See our new Ads at McMaster University on the

"I Saw the Sign" TVs located in Health Sciences and MDCL

I saw the sign 1

i saw the sign 2

You can also take advantage of participating in PURR. Help us with research!

Contact by phone or email for more information:

PURR

Pulmonary Research Registry (PURR) at the FIRH

Phone: 905-522-1155 ext 32722
Email: PURR@stjoes.ca

Project 1

Cat allergy is one of the commonest allergic sensitizations and is strongly associated with asthma. Children sensitized to cats are more likely to develop severe asthma than those sensitized to other allergens. Current treatment options for allergy to cats are largely symptomatic. However, allergen-specific immunotherapy (SIT) is available for desensitization to cats and has been demonstrated to be clinically effective in both allergic rhinitis and asthma.

Objective:

To understand how peptide immunotherapy, using validated T cell epitopes of a major allergen (Fel d 1), modulates the frequency and functional phenotype of Fel d 1-specific T cells using unique MHC

Project 2

Asthma, a disease/syndrome which affects up to 10% of the population of the United States, is identified by characteristic symptoms (such as periodic wheeze, shortness of breath etc) and by the physiological abnormalities of reversible airway obstruction and airway hyperresponsiveness (AHR) to a variety of inhaled bronchoconstrictor stimuli.   Asthma is also recognized as an inflammatory disease of the airways, with reversible airflow obstruction and AHR being physiological manifestations of either the cellular inflammation and/or the structural consequences of the inflammation.

Objective:

Our goal is to enumerate, functionally phenotype and track allergen-specific T cells in the peripheral blood, bone marrow and airways following allergen challenge, and to further understand the contribution of these allergen-specific T-cells in the initiation and maintenance of allergen-induced airway inflammation and hyperresponsiveness.