McMaster University

McMaster University

Other MPSRC Research Studies

The MPSRC is currently conducting the following clinical research studies:

Quantitative Research

Prospective Hypospadias Outcomes Long-term Database (HOLD)

Principal Investigator: Dr. Luis Braga

The objective of this project is to develop a reliable and quality registry of information on long-term surgical outcomes of hypospadias surgeries performed at McMaster Children's Hospital. This prospective database will produce consistent high-level evidence needed in hypospadias surgery and inform the future practice of pediatric urologists. This project also provides infrastructure that will facilitate and encourage future collaborative research among pediatric urologists. The future plan is to include participating centres from across Canada, the USA, Brazil, France and Italy to make this an international database connecting pediatric urologists from around the world.

Preventable Vision Loss in 4 Inner City Hamilton Elementary Schools – An Observational Study of the Prevalence and Causes of Amblyopia

Principal Investigator: Dr. Kourosh Sabri

This study will consist of screening each consented child at Cathy Wever, Bennetto, Dr. J. Edgar Davey and Hess Street elementary schools over the age of seven using a vision chart, a colour vision test and a depth perception test. A preliminary general diagnosis will be made based on these tests and those students identified as requiring a follow-up eye examination with a paediatric ophthalmologist will be given the opportunity to have an appointment. Dr. Sabri will make a final diagnosis and plan treatment for the patient based on a full eye exam.


Systematic/Scoping Reviews and Meta-Analyses

Pediatric Surgical Outcomes in Africa: A Scoping Review

Principal Investigator: Dr. Dan Poenaru

Indications for Surgical Intervention in Pectus Excavatum: A Scoping Review

Principal Investigator: Dr. Peter Fitzgerald

The Role of Anti-Reflux Medications in Minimizing the Impact of Gastro-esophageal Reflux in Patients Treated Surgically for Congenital Esophageal Atresia and Tracheo-esophageal Fistula: A Scoping Review

Principal Investigator: Dr. Helene Flageole

How Best to Measure Eye Pressure in Young Children? A Systematic Review of the Effects of Anesthetic Agents on Intraocular Pressure

Principal Investigator: Dr. Kourosh Sabri


Qualitative Research

Health-Related Quality of Life after Anorectal Surgery Repair in Children

Principal Investigator: Dr. Brian Cameron

The objective of this descriptive qualitative study is to identify patient and family health related quality of life issues specific to children who have undergone anorectal surgery at the McMaster Children's Hospital.

Understanding the Caregiver Quality of Life Experience Following Gastrostomy Tube Insertion in Pediatric Patients: A Qualitative Phenomenological Approach

Principal Investigator: Dr. Mark Walton

The objective of this phenomenological qualitative study is to identify quality of life issues specific to parents of children who have undergone gastrostomy surgery at the McMaster Children's Hospital.


Educational Research

Neonatal Circumcision: An Educational Surgical Training Website

Principal Investigator: Dr. Jorge DeMaria

The main objective of this project is to create a standardized, accessible, web-based instruction module to help reduce the complication rates of neonatal circumcision.

TTT Update Course Development

The Trauma Team Training Course is a nationally accredited trauma program in Guyana. The TTT Update course was piloted November 2011 to allow TTT graduates to sharpen skills while focusing on teamwork capacity. Study results will help inform the development of an official TTT Update manual for the Canadian Network for International Surgery. An abstract and a poster for this project were presented at the 2012 Bethune Round Table Conference.

Creation of Bowel Anastomosis Competency Module for Residents

A Resident Project by Dr. Jennifer Li

Principal Investigator: Dr. Brian Cameron


Evidence Based Reviews

Quality of Reporting over 10 years in Randomized Controlled Trial Published in
the Journal of Pediatric Surgery

Principal Investigator: Dr. Peter Fitzgerald

Quality of Reporting in Hypospadias Randomized Controlled Trial Published over 5 years

Principal Investigator: Dr. Luis Braga

The Scientific Program at the Canadian Association of Pediatric Surgery National Meetings:
Is the Level of Evidence Changing?

Principal Investigator: Dr. Helene Flageole


The MPSRC is currently participating in the following clinical research studies:


Astellas Trials

This clinical trial, sponsored by Astellas Pharma Europe B.V, is currently being coordinated by Jessie Heaman of the MPSRC under the supervision Dr. Luis Braga. The objective is to study the long-term safety, efficacy, and pharmacokinetics of Solifenacin Succinate Suspension, a new treatment for pediatric patients with overactive bladder (OAB) or Neurogenic Detrusor Overactivity (NDO). This study is being conducted in three different parts called the Lion, Leopard, and Monkey studies. Each study examines the study drug in a specific population of pediatric patients.

Local Principal Investigator: Dr. Luis Braga

Sponsoring Company: Astellas Pharma Europe B.V.

Astellas

Moxipedia Trial

The Moxipedia trial is a randomized, double-blind, multicenter trial to evaluate the safety and efficacy of sequential (intravenous, oral) moxifloxacin in pediatric subjects with complicated intra-abdominal infection versus standard therapy.

Local Principal Investigator: Dr. Karen Bailey

Sponsoring Company: Bayer Healthcare AG

Bayer Healthcare AG

 

SMOF Trial

Can SMOFlipid®, a Composite Parenteral Nutrition Lipid Emulsion, Prevent Progression Of Parenteral Nutrition Associated Liver Disease in Infants? A Pilot Double Blind Randomized Controlled Trial.

Local Principal Investigator: Dr. Peter Fitzgerald
Principal Investigator: Dr. Paul Wales, Hospital for Sick Children

The aim of this study is to perform a pilot trial that will be used to determine feasibility and to generate data that will be used to design a more definitive trial to address the question of whether the administration of SMOFlipid® rather than Intralipid® prevents the progression of liver disease in infants with SBS and early PNALD in a double blind randomized control trial. This trial is coordinated by the Hospital of Sick Children in Toronto, and the McMaster Children's Hospital is a participating centre in this multi-centre initiative.

Hospital of Sick Children in Toronto

CAPSNet

The Canadian Pediatric Surgery Network (CAPSNet) is a multi-speciality Canadian collaborative established in 2005 to enable systematic study of the two most common structural birth defects encountered by pediatric general surgeons: gastroschisis (GS) and congenital diaphragmatic hernia (CDH).

Local Principal Investigator: Dr. Peter Fitzgerald
Principal Investigator: Dr. Eric Skarsgard, British Columbia's Children's Hospital

Canadian Pediatric Surgery Network (CAPSNet)

STEP Database

The STEP database aims to create a web-based data registry for all patients worldwide who undergo the serial transverse enteroplasty (STEP) procedure, analyze the data from the STEP registry to determine a baseline diagnostic, demographic, anatomical, and nutritional profile for patients who undergo the STEP procedure, and analyze long-term data from the STEP registry to determine and measure long-term clinical outcomes of patients who undergo the STEP procedure.

Local Principal Investigator: Dr. Brian Cameron

Principal Investigator: Children's Hospital Boston

Children's Hospital Boston

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