McMaster University

Medical Sciences
Graduate Program

Scope of Search

Jeffrey Weitz

Jeffrey Weitz

MD, FRCP (C), FACP, FCCP
Professor

Research Interests

Research is focused on the molecular mechanisms of coagulation and fibrinolysis with emphasis on the clinical significance of findings.


Specific topics currently under investigation include:

  1. Mechanism of action of plasminogen activators
  2. Structure-activity relationships of coagulation enzymes, and their inhibitors,
  3. Mechanisms of action and potential clinical utility of new antithrombotic and thrombolytic agents
  4. Clinical trials investigating optimal methods for the diagnosis and treatment of venous and arterial thrombosis

Light scattering, fluorescence spectroscopy, and plasmon resonance are employed to study protein/protein, protein/carbohydrate or protein/DNA interactions. Kinetic analyses are used to examine rates of enzyme inactivation, whereas molecular biologic techniques (site-directed mutagenesis and expression of recombinant proteins in bacterial or cultured mammalian cell systems) are used to investigate structure-activity relationships of clotting enzymes and inhibitors. Hypotheses that originate from the results of basic research are then tested in animal models of arterial and venous thrombosis or in humans.

Contact

McMaster University
Henderson Hospital Site

telephone: (905) 527-2299 ext. 42461
email: weitzj@mcmaster.ca

Program Area

Blood & Vasculature

Research Focus

Coagulation, Fibrinolysis, Thrombin, Thrombosis, Anticoagulants, Mutagenesis, Recombinant Proteins

Selected Publications

  • Thrombosis: a major contributor to global disease burden. Raskob GE, Angchaisuksiri P, Blanco AN, Buller H, Gallus A, Hunt BJ, Hylek EM, Kakkar A, Konstantinides SV, McCumber M, Ozaki Y, Wendelboe A, Weitz JI; ISTH Steering Committee for World Thrombosis Day Arterioscler Thromb Vasc Biol. 2014 Nov;34(11):2363-71. doi: 10.1161/ATVBAHA.114.304488.
  • Thrombosis: a major contributor to global disease burden. Raskob GE, Angchaisuksiri P, Blanco AN, B├╝ller H, Gallus A, Hunt BJ, Hylek EM, Kakkar TL, Konstantinides SV, McCumber M, Ozaki Y, Wendelboe A, Weitz JI; ; ISTH Steering Committee for World Thrombosis Day.

    Semin Thromb Hemost. 2014 Oct;40(7):724-35. doi: 10.1055/s-0034-1390325. Epub 2014 Oct 10.

  • The postthrombotic syndrome: evidence-based prevention, diagnosis, and treatment strategies: a scientific statement from the american heart association. Kahn SR, Comerota AJ, Cushman M, Evans NS, Ginsberg JS, Goldenberg NA, Gupta DK, Prandoni P, Vedantham S, Walsh ME, Weitz JI; American Heart Association Council on Peripheral Vascular Disease, Council on Clinical Cardiology, and Council on Cardiovascular and Stroke Nursing.

    Circulation. 2014 Oct 28;130(18):1636-61. doi: 10.1161/CIR.0000000000000130. Epub 2014 Sep 22. No abstract available.