McMaster University

Medical Sciences
Graduate Program

Scope of Search

 

Bernardo Trigatti

Bernardo Trigatti

 

BSc, PhD
Professor

Research Interests

Atherosclerosis is a major cause of heart disease and stroke, among the leading causes of hospitalization and death in Western countries. It is a multifactorial disease involving a variety of physiological pathways. These include innate immunity, inflammation and lipoprotein metabolism.

Our laboratory utilizes mouse molecular genetics to delineate the contribution of components of these pathways to the development of atherosclerosis. The mouse has been an extremely useful model genetic system to analyze pathways involved in atherosclerosis. In conventional mouse models of atherosclerosis, including the workhorse apoE and LDL receptor knockout mouse strains, atherosclerosis develops primarily in the aorta while coronary arteries, which feed the heart, appear resistant to disease. In contrast, mice that lack a receptor for high density lipoproteins develop extensive atherosclerosis in their coronary arteries as well as increased atherosclerosis in their aortas. These mice develop myocardial infarction as a result of the extensive coronary artery atherosclerosis. This suggests that the HDL receptor, called SR-BI, plays a key role in protection against coronary artery atherosclerosis. One of the main focuses of the lab is to delineate the mechanisms by which expression of SR-BI in bone marrow derived cells including macrophages, protects against atherosclerosis. In particular, we are interested in understanding the role of this receptor in lipid transport as well as cell signalling.

We are also making use of our mouse models of coronary artery atherosclerosis to delineate the factors that normally contribute to the resistance of mouse coronary arteries to atherosclerosis development, as well as to test the contribution of different physiological pathways to the development of coronary artery atherosclerosis and myocardial infarction.

Contact

McMaster University
Health Sciences Centre

telephone: (905) 521-2100 Extension 40744
email: trigatt@mcmaster.ca

 

Program Area

Blood & Vasculature

 

Research Focus

Atherosclerosis, Cardiovascular Disease, Glycosylation, Inflammation, Knockout, Lipoprotein, Mouse Genetics,Transgenic, Vascular Biology

Selected Publications

  • The effects of diet on occlusive coronary artery atherosclerosis and myocardial infarction in scavenger receptor class B, type 1/low-density lipoprotein receptor double knockout mice.

    Fuller M, Dadoo O, Serkis V, Abutouk D, MacDonald M, Dhingani N, Macri J, Igdoura SA, Trigatti BL. Arterioscler Thromb Vasc Biol. 2014 Nov;34(11):2394-403. doi: 10.1161/ATVBAHA.114.304200. Epub 2014 Sep 11.

  • High density lipoprotein stimulated migration of macrophages depends on the scavenger receptor class B, type I, PDZK1 and Akt1 and is blocked by sphingosine 1 phosphate receptor antagonists. Al-Jarallah A, Chen X, Gonz├ílez L, Trigatti BL. PLoS One. 2014 Sep 4;9(9):e106487. doi: 10.1371/journal.pone.0106487. eCollection 2014.
  • SR-BI in bone marrow derived cells protects mice from diet induced coronary artery atherosclerosis and myocardial infarction. Pei Y, Chen X, Aboutouk D, Fuller MT, Dadoo O, Yu P, White EJ, Igdoura SA, Trigatti BL. PLoS One. 2013 Aug 13;8(8):e72492. doi: 10.1371/journal.pone.0072492. eCollection 2013.