The overall theme of our research is an evaluation of treatment strategies to attenuate the effect of neuromuscular disorders and aging on skeletal muscle function.
Currently, we are looking at a number of nutritional and exercise interventions to enhance muscle function in response to neuromuscular, neurometabolic disorders as well as in the aging process. We have transgenic animal models of several neuromuscular disorders and are also completing clinical trials in patients with these conditions. Another line of research is the role of mitochondria in aging and the role of oxidative stress/apoptosis in skeletal muscle damage in response to exercise and neuromuscular disorders.
We use a variety of methods in the laboratory from strength and functional outcome measures in the dry laboratory to Western blotting, RT-PCR, PCR, enzyme analysis, metabolite analysis, ELISA, microscopy (immuno, EM and fluorescent methods), GC-MS, micro array, HPLC and RIA.