Pediatric Diabetes, Translational Research, Child Health, Metabolism, Inflammation, Immunometabolism, Pediatric Obesity, Knowledge Synthesis, Knowledge Translation
Dr. M. Constantine Samaan is a staff physician in the division of Pediatric Endocrinology and Associate Professor in the Department of Pediatrics at McMaster University and McMaster Children's Hospital.
Dr. Samaan’s research program is in the area of translational research, with specific focus on pediatric diabetes.
Goals of Dr. Samaan’s research program:
The specific focus of Dr. Samaan’s program of research include the following platforms
1. Investigate the determinants of diabetes in at-risk populations
2. Evaluation of interventions to manage diabetes in children
3. Knowledge Translation (KT) through the conduct of systematic reviews and meta-analysis
This bedside-to-bench side approach to research allows the comprehensive study of the drivers of pediatric diabetes, and the evaluation of specific therapeutic and preventative strategies for diabetes.
The clinical studies focus on understanding what keeps children healthy, and what environmental and psychosocial factors increase the risk of diabetes. We work with several pediatric populations who already have or at risk of developing diabetes.
The bench studies use a state-of-the-art molecular and cell biology platforms to define mechanisms responsible for the development of diabetes. An important component of this platform is the investigation of the role of immune system activation and inflammation in driving diabetes in children and across the lifespan.