McMaster University

Medical Sciences
Graduate Program

Scope of Search

Dr. Samaan

M. Constantine Samaan

Associate Professor

Research Interests

Research themes
Pediatric Diabetes, Translational Research, Child Health, Metabolism, Inflammation, Immunometabolism, Pediatric Obesity, Knowledge Synthesis, Knowledge Translation

Dr. M. Constantine Samaan is a staff physician in the division of Pediatric Endocrinology and Associate Professor in the Department of Pediatrics at McMaster University and McMaster Children's Hospital.
Dr. Samaan’s research program is in the area of translational research, with specific focus on pediatric diabetes.

Goals of Dr. Samaan’s research program:
The specific focus of Dr. Samaan’s program of research include the following platforms
1. Investigate the determinants of diabetes in at-risk populations
2. Evaluation of interventions to manage diabetes in children
3. Knowledge Translation (KT) through the conduct of systematic reviews and meta-analysis

This bedside-to-bench side approach to research allows the comprehensive study of the drivers of pediatric diabetes, and the evaluation of specific therapeutic and preventative strategies for diabetes.

The clinical studies focus on understanding what keeps children healthy, and what environmental and psychosocial factors increase the risk of diabetes. We work with several pediatric populations who already have or at risk of developing diabetes.
The bench studies use a state-of-the-art molecular and cell biology platforms to define mechanisms responsible for the development of diabetes. An important component of this platform is the investigation of the role of immune system activation and inflammation in driving diabetes in children and across the lifespan.


McMaster University
Health Sciences Centre

telephone: (905) 525-9140 ext. 73716

Program Areas

Metabolism & Nutrition

Research Focus

Immunometabolism, childhood obesity, Pediatric Endocrinology, type 2 diabetes, inflammation, metabolism, cytokines, translational research

Selected Publications

  • M. Constantine Samaan, Sonia S. Anand, Imtiaz Samjoo, Arya M. Sharma, Ashley Bonner, Joseph Beyene, Mark Tarnopolsky. Adiposity and immune-muscle crosstalk in South Asians & Europeans: A cross-sectional study. Scientific Reports, Sept 2015.

  • Samaan, M.C., Anand, S.S, Sharma, A.M., Bonner, A., Samjoo, I., Tarnopolsky, M. Sex differences in skeletal muscle Phosphatase and tensin homolog deleted on Chromosome 10(PTEN) levels: A Cross-sectional study. Scientific Reports, 2015 Mar 17;5:9154. doi: 10.1038/srep09154.

  • Samaan,M.C., Valencia,M., Cheung,C., Wilk,B,. Lau.K., Thabane,L. The Design, Implementation and evaluation of Pediatric & Adolescent Type 2 diabetes Management Program in a Tertiary Pediatric Center. Journal of Multidisciplinary Healthcare. 7: 321-331. Jul 2014.

  • M Constantine Samaan, Lehana Thabane, Sarah Burrow, Rejane F Dillenburg, Katrin Scheinemann. Canadian Study of Determinants of Endometabolic Health in ChIlDrEn (CanDECIDE study): a cohort study protocol examining the mechanisms of obesity in survivors of childhood brain tumours. BMJ Open 06/2013; 3(6). DOI:10.1136/bmjopen-2013-002869