McMaster University

Medical Sciences
Graduate Program

Scope of Search

DNA

Lennard P. Niles

BA, MSc, PhD
Professor

Research Interests

Molecular neuroendocrinology and neuropharmacology. Cellular and molecular mechanisms underlying drug-induced neuroprotection in animal models of neurodegeneration.


Current research projects include:

  1. Neurotrophic factor (eg GDNF, BDNF, NGF) induction by the neuroprotective hormones and drugs
  2. Stem cell transplantation and drug administration in neurotoxin models of Parkinson's disease
  3. Epigenetic modulation of gene expression in glial and neuronal cell lines by hormones, neurotransmitters and psychotropic drugs

Pharmacological, immunohistochemical and molecular studies in brain, cultured stem cells, neuronal and glial cell lines. Stereotaxic lesioning and neural stem cell transplantation in the brain. Examination of mRNA expression by RT-PCR and in situ hybridization. Confirmation of target gene expression by sequencing. Examination of protein expression by Western blotting, enzyme activity assays, immunohistochemistry and receptor binding assays. Reporter gene assays of promoter activity.

Contact

McMaster University
Health Sciences Centre

telephone: (905) 525-9140 ext. 22224
email: niles@mcmaster.ca

Program Area

Physiology & Pharmacology

Research Focus

Molecular neuroendocrinology and Neuropharmacology

Selected Publications

  • Regional upregulation of hippocampal melatonin MT2 receptors by valproic acid: therapeutic implications for Alzheimer's disease. Bahna SG, Sathiyapalan A, Foster JA, Niles LP.

    Neurosci Lett. 2014 Jul 25;576:84-7. doi: 10.1016/j.neulet.2014.05.056. Epub 2014 Jun 5.

  • Neuroprotection by valproic acid in an intrastriatal rotenone model of Parkinson's disease.

    Carriere CH, Kang NH, Niles LP. Neuroscience. 2014 May 16;267:114-21. doi: 10.1016/j.neuroscience.2014.02.028. Epub 2014 Mar 6.

  • Induction of neurotrophic and differentiation factors in neural stem cells by valproic acid.

    Almutawaa W, Kang NH, Pan Y, Niles LP. Basic Clin Pharmacol Toxicol. 2014 Aug;115(2):216-21. doi: 10.1111/bcpt.12201. Epub 2014 Feb 20.