McMaster University

Medical Sciences
Graduate Program

Scope of Search

Carlos K. Morillo

Carlos K. Morillo

MD, FRCP (C), FACC
Professor

Research Interests

The primary focus of my work is the understanding of the physiologic mechanisms that control blood pressure and heart rate during different physiologic and non-physiologic stimuli in humans. I have a particular interest in baroreflex control both at the vagal and sympathetic levels and their role during different situations such as vasovagal syncope, supraventricular and ventricular tachycardias. I also have a great interest in the role of cardiovascular reflex responses and their prognostic value in coronary artery disease, sudden cardiac death and stroke.


Specific studies include:

  1. Investigation of cardiovascular autonomic control during orthostatic stress in subjects with recurrent vasovagal syncope
  2. Determine the role of cardiac resynchronization therapy and restoration of cardiac and vascular reflexes
  3. Determine the prognostic value of baroreflex sensitivity, heart turbulence and T wave alternans in patients at risk of sudden cardiac death
  4. Effects of simulated ventricular tachycardia on sympathetic and vagal baroreflex mechanisms
  5. Investigation of the normal baroreflex and vascular response to orthostatic stress in male and female and in different age groups

Sympathetic Microneurography, baroreflex modulation, heart rate and blood pressure variability, linear and non-linear dynamics of biological signals, plethysmography, lower body negative pressure, tilt table testing.

Contact

McMaster University
Hamilton General Hospital

telephone: (905) 577-8004 ext. 1
email: morillo@hhsc.ca

Program Area

Physiology & Pharmacology

Research Focus

Cardiovascular Autonomic Response, Baroreflexes, Heart rate variability, Blood Pressure, Autonomic Nervous System

Selected Publications

  • Reduced-dose warfarin or interrupted warfarin with heparin bridging for pacemaker or defibrillator implantation: a randomized trial. Schulman S, Healey JS, Douketis JD, Delaney J, Morillo CA. Thromb Res. 2014 Oct;134(4):814-8. doi: 10.1016/j.thromres.2014.07.028. Epub 2014 Aug 1.
  • Defibrillator discharges in a young patient: What is the underlying arrhythmia? Kansal N, Healey JS, Morillo CA, Divakara Menon SM. Heart Rhythm. 2014 Jul 28. pii: S1547-5271(14)00809-1. doi: 10.1016/j.hrthm.2014.07.036. [Epub ahead of print] No abstract available.
  • Cryptogenic stroke and underlying atrial fibrillation. Sanna T, Diener HC, Passman RS, Di Lazzaro V, Bernstein RA, Morillo CA, Rymer MM, Thijs V, Rogers T, Beckers F, Lindborg K, Brachmann J; CRYSTAL AF Investigators. N Engl J Med. 2014 Jun 26;370(26):2478-86. doi: 10.1056/NEJMoa1313600.