McMaster University

Medical Sciences
Graduate Program

Scope of Search

 

Peter J. Margetts

Peter J. Margetts

 

BSc, MD, PhD, FRCPC
Professor

Research Interests

I am presently investigating the pathology of tissue fibrosis pertaining to kidneys and the peritoneum. I am interested in cytokines, growth factors, and cells involved in the progression or maintenance of fibrosis and tissue regeneration; the role of angiogenesis in fibrosis; and gene therapy and pharmacologic techniques to interfere with fibrosis.

I am specifically studying the process of epithelial mesenchymal transition in peritoneal fibrosis. This is a central process in the early stage of fibrosis, and transition to metastatic disease. I have been interested in localized gene expression and use laser capture microdissection to evaluate mRNA responses in progressive or resolving tissue injury. I have been studying the role of transforming growth factor beta in angiogenesis and specifically the regulation of angiopoietins in fibrotic tissue. These studies have wide applicability to scar formation, ischemic disease, and cancer. We have used adenovirus mediated gene therapy to inhibit fibrosis and angiogenesis and are exploring other gene therapy techniques. I have also studied the use of novel pharmacologic agents for modulating the fibrogenic response; specifically the chemotherapeutic agents paclitaxel and thalidomide.

We use adenovirus mediated gene transfer, animal models of renal disease and peritoneal fibrosis, transgenic animals, cell culture techniques, quantitative real time PCR, western blot, ELISA, zymography, histology, fluorescent and light immunohistochemistry, EM, and laser capture microdissection.

Contact

McMaster University
St. Joseph's Healthcare

telephone: (905) 522-1155 ext. 32299
email: margetts@mcmaster.ca

 

Program Area

Infection & Immunity

 

Research Focus

Adenovirus, Fibrosis, Angiogenesis, Gene Therapy, Laser Capture Microdissection, Gene Regulation, Renal Disease, Peritoneal Dialysis

Selected Publications

  • Gremlin Promotes Peritoneal Membrane Injury in an Experimental Mouse Model and Is Associated with Increased Solute Transport in Peritoneal Dialysis Patients.

    Siddique I, Curran SP, Ghayur A, Liu L, Shi W, Hoff CM, Gangji AS, Brimble KS, Margetts PJ. Am J Pathol. 2014 Sep 3. pii: S0002-9440(14)00436-2. doi: 10.1016/j.ajpath.2014.07.018. [Epub ahead of print].

  • The role of mouse strain differences in the susceptibility to fibrosis: a systematic review.

    Walkin L, Herrick SE, Summers A, Brenchley PE, Hoff CM, Korstanje R, Margetts PJ. Fibrogenesis Tissue Repair. 2013 Sep 25;6(1):18. doi: 10.1186/1755-1536-6-18.

  • Peritoneal dialysis-moving from current status to the future. Oh KH, Kim YL, Lo WK, Margetts PJ. Int J Nephrol. 2013;2013:530713. doi: 10.1155/2013/530713. Epub 2013 Oct 24. No abstract available.