McMaster University

Medical Sciences
Graduate Program

Scope of Search

Derek K. Lobb

Derek K. Lobb

BSc, MSc, PhD
Associate Professor

Research Interests

Reproductive hormones and their effects

Many of the peptide hormones and growth factors synthesized within the gonads also act on neighbouring cells in a paracrine manner. Included among these are relaxin, a member of the insulin family of genes and the transforming growth factors. We have found relaxin in the non-pregnant ovary and in the testis and are examining its effects on cell growth, steroidogenesis and tissue remodelling in the reproductive tract. We are using relaxin to treat human cervical cells in vitro to determine which proteases are involved in cervical softening.

Cell culture, hormone assays, blotting, RT-PCR.

Contact

McMaster University
Health Sciences Centre

telephone: (905) 525-9140 ext. 22228
email: lobbd@mcmaster.ca

Specialty

Physiology & Pharmacology

Research Focus

Ovary, Testis, Growth-Factors, Relaxin, Cervix, Ovarian Cancer

Selected Publications

  • Student attrition in the Ontario midwifery education programme.

    Wilson R, Eva K, Lobb DK. Midwifery. 2013 Jun;29(6):579-84. doi: 10.1016/j.midw.2012.04.015. Epub 2012 Nov 7.

  • Niles, L.P., Lobb, D.K., Kang, N.Y. and Armstrong, K.J. (2012) Resistin expression in human granulosa cells. Endocrine 42: 742-745.
  • Kong, R.C., Shilling, P.J., Lobb, D.K., Gooley, P.R., Bathgate, R.A. (2010) Membrane receptors: Structure and function of the relaxin family peptide receptors. Mol Cell Endocrinol. 320: 1 - 15.