McMaster University

Medical Sciences
Graduate Program

Scope of Search

 

Patricia Liaw

Patricia Liaw

 

BSc, MSc, PhD
Professor

Research Interests

Our overall research interest is to study the mechanistic links between blood clotting, inflammation, and the host immune system. We integrate lab-based studies with clinical/translational projects to better understand why dysregulation of these pathways contributes to vascular disease states such as thrombosis and sepsis.

 


 

Our research focuses on three key areas:


1. Role of immune cells in the pathophysiology of thrombosis
2. Novel pre-clinical strategies for the treatment of sepsis
3. Precision medicine approach for the treatment of sepsis

 


 

We perform studies at the levels of cell biology, biochemistry, molecular biology, mouse models of sepsis, and human patients.

Contact

McMaster University

Thrombosis & Atherosclerosis Research Institute (TaARI)
Hamilton General Site

telephone: (905) 521-2100 ext.40788
email: patricia.liaw@taari.ca

 

Program Area

Blood & Vasculature

 

Research Areas


Blood coagulation, thrombosis, critical care, innate immunity, sepsis, vascular biology, endothelium, neutrophils, animal models, human studies

Selected Publications

Liaw PC, Fox-Robichaud AE, Liaw KL, McDonald E, Dwivedi DJ et al. Mortality Risk Profiles for Sepsis: A Novel Longitudinal and Multivariable Approach. Crit Care Explorations. 2019:e0032.

 

Medeiros SK, Zafar N, Liaw PC*, Kim PY*. Purification of silica-free DNA and characterization of its role in coagulation. J Thromb Haemost. 2019 Nov;17(11):1860-1865. * co-senior author.

Jackson Chornenki NL, Coke R, Kwong AC, Dwivedi DJ, Xu MK, McDonald E, Marshall JC, Fox-Robichaud AE, Charbonney E, Liaw PC. Comparison of the source and prognostic utility of cfDNA in trauma and sepsis. Intensive Care Med Exp. 2019 May 22;7(1):29.

Mai SHC, Sharma N, BSc; Kwong AC, Dwivedi DJ, Khan M, Grin PM, Fox-Robichaud AE, Liaw PC. Body temperature and mouse scoring systems as surrogate markers of death in cecal ligation and puncture sepsis. Intensive Care Med Exp. 2018 Jul 27;6(1):20.

Swystun LL, Liaw PC. The role of leukocytes in thrombosis. Blood. 2016; Aug 11;128(6):753-62.

Dwivedi DJ, Grin PM, Khan M, Prat A, Zhou J, Fox-Robichaud AE, Seidah NG, Liaw PC. Differential Expression of PCSK9 Modulates Infection, Inflammation and Coagulation in a Murine Model of Sepsis. Shock. 2016; Dec;46(6):672-680.

Gould TJ, Vu TT, Stafford AR, Dwivedi DJ, Kim PY, Fox-Robichaud AE, Weitz JI, Liaw PC. Cell-Free DNA Modulates Clot Structure and Impairs Fibrinolysis in Sepsis. Arterioscler Thromb Vasc Biol. 2015; Dec; 35(12):2544-53.

Pepler L, Dwivedi D, Liaw PC. Pepler L, Dwivedi D, Liaw PC. Characterization of mice harboring an EPCR variant with impaired ability to bind protein C: Novel role of EPCR in hematopoiesis Blood. 2015; Jul 30;126(5):673-82.

Mai SH, Khan M, Dwivedi DJ, Ross CA, Zhou J, Gould TJ, Gross PL, Weitz JI, Fox-Robichaud AE, Liaw PC. Delayed But Not Early Treatment With DNase Reduces Organ Damage and Improves Outcome in a Murine Model of Sepsis. Shock. 2015; Aug;44(2):166-72.