McMaster University

Medical Sciences
Graduate Program

Scope of Search

Mark Larché

Mark Larché


Research Interests

Translational medicine; development of peptide-based vaccines for chronic immunological diseases including asthma, allergy, autoimmunity and transplantation-related diseases.

Immunological mechanisms of asthma. Human in vivo experimental models of T lymphocyte activation and mast cell-independent asthma.

Experimental in vivo modeling of asthma, scleroderma, systemic lupus erythematosus (SLE) and GVHD.


McMaster University
Health Sciences Centre

telephone: (905) 525-9140 ext. 21284

Program Area

Infection & Immunity

Research Focus

Immunology, Immunotherapy, T cell, Epitope, Peptide, Vaccine, Allergy, Asthma, Autoimmunity, Transplantation, Translational medicine

Selected Publications

  • Natural regulatory T cells in isolated early responders compared with dual responders with allergic asthma.Kinoshita T, Baatjes A, Smith SG, Dua B, Watson R, Kawayama T, Larche M, Gauvreau GM, O'Byrne PM. J Allergy Clin Immunol. 2014 Mar;133(3):696-703. doi: 10.1016/j.jaci.2013.08.025. Epub 2013 Oct 15.
  • Amelioration of ovalbumin-induced allergic airway disease following Der p 1 peptide immunotherapy is not associated with induction of IL-35. Moldaver DM, Bharhani MS, Wattie JN, Ellis R, Neighbour H, Lloyd CM, Inman MD, Larché M. Mucosal Immunol. 2014 Mar;7(2):379-90. doi: 10.1038/mi.2013.56. Epub 2013 Aug 14.
  • The effect of rituximab on vaccine responses in patients with immune thrombocytopenia.

    Nazi I, Kelton JG, Larché M, Snider DP, Heddle NM, Crowther MA, Cook RJ, Tinmouth AT, Mangel J, Arnold DM. Blood. 2013 Sep 12;122(11):1946-53. doi: 10.1182/blood-2013-04-494096. Epub 2013 Jul 12.