McMaster University

Medical Sciences
Graduate Program

Scope of Search

Renée Labiris

N. Renée Labiris

BSc, MSc, PhD
Assistant Professor

Research Interests

The use of molecular imaging to bridge the gap between preclinical and clinical investigations of the efficacy of drug therapy and diagnosis and progression of respiratory diseases.

My research is focussed on the development of methods to visualize in situ lung disease and pharmacokinetics and pharmacodynamic properties of inhaled therapies in both animal models of disease and humans, using radiopharmaceuticals and 3-dimensional imaging techniques. Current research involves preclinical molecular imaging of animal models of respiratory disease, including pulmonary fibrosis, COPD, and lung infections, to study disease progression and impact of therapy on disease processes. Clinical imaging studies include cystic fibrosis COPD.

These studies employ techniques in molecular imaging, including positron emission tomography (PET), single photon emission computed tomography (SPECT), and radiopharmaceuticals to measure the pathogenesis of disease as well as drug distribution. Principles of pharmacokinetics are employed to measure the uptake and distribution of the radiopharmaceuticals.

Contact

McMaster University
Health Sciences Centre

telephone: (905) 521-2100 ext. 75657
email: labir@mcmaster.ca

Program Area

Physiology & Pharmacology

Research Focus

Molecular imaging, Lung Imaging, Drug Targeting in the lung, Positron Emission Tomography, Single Photon Emission Computed Tomography, X-ray Computed Tomography, Aerosolized Drug Formulations, Pharmacokinetics, Pulmonary Pharmacology

Selected Publications

  • Synthesis and characterization of rhenium and technetium-99m labeled insulin.

    Sundararajan C, Besanger TR, Labiris R, Guenther KJ, Strack T, Garafalo R, Kawabata TT, Finco-Kent D, Zubieta J, Babich JW, Valliant JF. J Med Chem. 2010 Mar 25;53(6):2612-21. doi: 10.1021/jm100096

  • Evaluation of allergic lung inflammation by computed tomography in a rat model in vivo. Jobse BN, Johnson JR, Farncombe TH, Labiris R, Walker TD, Goncharova S, Jordana M. Eur Respir J. 2009 Jun;33(6):1437-47. Epub 2009 Jan 22.
  • Role of STAT6 and SMAD2 in a model of chronic allergen exposure: a mouse strain comparison study. Hirota JA, Ask K, Fritz D, Ellis R, Wattie J, Richards CD, Labiris R, Kolb M, Inman MD. Clin Exp Allergy. 2009 Jan;39(1):147-58. Epub 2008 Oct 11.
  • Comparison between conventional and "clinical" assessment of experimental lung fibrosis. Ask K, Labiris R, Farkas L, Moeller A, Froese A, Farncombe T, McClelland GB, Inman M, Gauldie J, Kolb MR. J Transl Med. 2008 Apr 10;6:16.