To investigate the mechanism of impaired wound healing after acute or chronic lung injury, which leads to progressive fibrogenesis in the lung parenchyma and airways and can result in respiratory failure.
The growth factors produced in the lung that trigger progressive fibrogenesis. The differentiation of local fibroblasts into myofibroblasts. The recruitment of circulating mesenchymal progenitor cells to the site of tissue injury. Epithelial mesenchymal transition in the lungs. Drug effects on the lung fibrogenesis, use of molecular therapies.
Animal models of lung fibrosis. Adenoviral gene transfer. Analysis of gene expression and signaling cascades. Progenitor cell biology. Small animal imaging techniques (SPEC CT and PET scan).
Clinical trials in Idiopathic Pulmonary Fibrosis patients and evaluation of biomarkers for chronic lung diseases.