McMaster University

Medical Sciences
Graduate Program

Scope of Search

Martin Kolb

Martin Kolb

MD, PhD
Professor

Research Interests

To investigate the mechanism of impaired wound healing after acute or chronic lung injury, which leads to progressive fibrogenesis in the lung parenchyma and airways and can result in respiratory failure.

The growth factors produced in the lung that trigger progressive fibrogenesis. The differentiation of local fibroblasts into myofibroblasts. The recruitment of circulating mesenchymal progenitor cells to the site of tissue injury. Epithelial mesenchymal transition in the lungs. Drug effects on the lung fibrogenesis, use of molecular therapies.

Animal models of lung fibrosis. Adenoviral gene transfer. Analysis of gene expression and signaling cascades. Progenitor cell biology. Small animal imaging techniques (SPEC CT and PET scan).

Clinical trials in Idiopathic Pulmonary Fibrosis patients and evaluation of biomarkers for chronic lung diseases.

Contact

McMaster University
St. Joseph's Healthcare

telephone: (905) 522-1155 ext. 34929
email: kolbm@mcmaster.ca

Program Area

Infection & Immunity

Research Focus

Lung Fibrosis,Tissue Repair, GeneTherapy, Small Animal Imaging, Drug Trials, Clinical Research

Selected Publications

  • Influenza Promotes Collagen Deposition via αvβ6-integrin Mediated Transforming Growth Factor β Activation. Jolly L, Stavrou A, Vanderstoken G, Meliopoulos VA, Habgood A, Tatler AL, Porte J, Knox A, Weinreb P, Violette S, Hussell T, Kolb M, Stampfli MR, Schultz-Cherry S, Jenkins G. J Biol Chem. 2014 Oct 22. pii: jbc.M114.582262. [Epub ahead of print].
  • Multiblock copolymer solutions in contact with a surface: self-assembly, adsorption, and percolation. Hugouvieux V, Kolb M. Langmuir. 2014 Oct 21;30(41):12400-10. doi: 10.1021/la502945k. Epub 2014 Oct 6.
  • Pulmonary and cardiac function in asymptomatic obese subjects and changes following a structured weight reduction program: a prospective observational study. Held M, Mittnacht M, Kolb M, Karl S, Jany B. PLoS One. 2014 Sep 18;9(9):e107480. doi: 10.1371/journal.pone.0107480. eCollection 2014.