Primary research interest is in the relationship between pathology and dysfunction in asthma. To investigate we reproduce some of the immune and pathologic features of asthma in several mouse models. Current directions include determining the relationship between morphologic changes and airway hyperresponsiveness and examining the effect of pharmacologic intervention in these models.
The role and mechanisms of bone marrow events in the development of allergen-induced airway pathologies. We are interested in the mechanisms by which bone marrow production of specific inflammatory cells is increased following allergen challenge in mice, and whether this mechanism would be a potential site for pharmacologic intervention.
Clinical methods for comparing the relative potency of asthma medications. Currently we are investigating methods to compare the efficacy of different inhaled steroid in the management of exercise-induced bronchoconstriction.