McMaster University

Medical Sciences
Graduate Program

Scope of Search


Mark D. Inman

Mark D. Inman


B.Sc., M.Sc., MD, PhD

Research Interests

Primary research interest is in the relationship between pathology and dysfunction in asthma. To investigate we reproduce some of the immune and pathologic features of asthma in several mouse models. Current directions include determining the relationship between morphologic changes and airway hyperresponsiveness and examining the effect of pharmacologic intervention in these models.

The role and mechanisms of bone marrow events in the development of allergen-induced airway pathologies. We are interested in the mechanisms by which bone marrow production of specific inflammatory cells is increased following allergen challenge in mice, and whether this mechanism would be a potential site for pharmacologic intervention.

Clinical methods for comparing the relative potency of asthma medications. Currently we are investigating methods to compare the efficacy of different inhaled steroid in the management of exercise-induced bronchoconstriction.


McMaster University
St. Joseph's Healthcare

telephone: (905) 522-1155 ext. 33694


Program Area

Physiology & Pharmacology


Research Focus

Asthma, Physiology, Morphology, Lung, Inflammation, Morphometry, Airway Hyperresponsiveness, Bone Marrow, Hematopoiesis

Selected Publications

  • Lung-homing of endothelial progenitor cells and airway vascularization is only partially dependant on eosinophils in a house dust mite-exposed mouse model of allergic asthma.

    Sivapalan N, Wattie J, Inman MD, Sehmi R. PLoS One. 2014 Oct 3;9(10):e109991. doi: 10.1371/journal.pone.0109991. eCollection 2014.

  • Amelioration of ovalbumin-induced allergic airway disease following Der p 1 peptide immunotherapy is not associated with induction of IL-35. Moldaver DM, Bharhani MS, Wattie JN, Ellis R, Neighbour H, Lloyd CM, Inman MD, Larché M.Mucosal Immunol. 2014 Mar;7(2):379-90. doi: 10.1038/mi.2013.56. Epub 2013 Aug 14.
  • Increased ornithine-derived polyamines cause airway hyperresponsiveness in a mouse model of asthma. North ML, Grasemann H, Khanna N, Inman MD, Gauvreau GM, Scott JA.

    Am J Respir Cell Mol Biol. 2013 Jun;48(6):694-702. doi: 10.1165/rcmb.2012-0323OC.