McMaster University

Medical Sciences
Graduate Program

Scope of Search

 

Alison Holloway

Alison Holloway

 

BSc, PhD
Associate Professor

Research Interests

Dr. Holloway's research is focused on examining the mechanisms by which chemical insults in fetal or adult life can cause metabolic endocrine disruption in animal and human populations. The central theme of her current research is to examine how exposure to various chemicals during pregnancy can cause adverse postnatal metabolic outcomes including type 2 diabetes and obesity. The chemicals that are of interest to her laboratory include: chemicals we may intentionally expose ourselves to through lifestyle choices or the use of over the counter natural health products; man-made chemicals present in the environment and naturally occuring chemicals in our diet (e.g. plant phytoestrogens). The majority of the work in her lab at this time focuses on the consequences of fetal and neonatal exposure to consistuents of cigarette smoke and smoking cessation pharmacotherapies.

Contact

McMaster University
Health Sciences Centre

telephone: (905) 525-9140 ext. 22130
email: hollow@mcmaster.ca

 

Program Area

Physiology & Pharmacology

 

Research Focus

Fetal Origins of Adult Disease, Environmental Contaminants, Obesity,Type 2 Diabetes, Infertility, Endocrine Toxicology

Selected Publications

De Long NE, JJ Petrik and AC Holloway. 2015. Fetal exposure to sertraline hydrochloride impairs pancreatic beta cell development. Endocrinology 156: 1952-1957.


De Long NE, DB Hardy, N Ma and AC Holloway. 2017. Increased incidence of non-alcoholic fatty liver disease in male rat offspring exposed to fluoxetine during fetal and neonatal life involves the NLRP3 inflammasome and augmented de novo hepatic lipogenesis. J Appl Tox 37: 1507-1516.

 

Raez-Villanueva S, Ma C, Kleiboer S and AC Holloway. 2018. The effects of electronic cigarette vapor on placental trophoblast cell function. Reprod Toxicol. 81: 115-121.

Raez-Villanueva S, Jamshed L, Ratnayake G, Cheng L, Thomas PJ and Holloway AC. 2019. Adverse effects of naphthenic acids on reproductive health: A focus on placental trophoblast cells. Reprod Toxicol. 90: 126-133.