We are studying the biology of human ovarian carcinoma to determine factors important in the growth and metastasis of this tumour. The malignant ascites produced by this tumour has been demonstrated to possess growth stimulatory activity which appears to be due to a novel growth factor. Using the technique of mRNA differential display, we are identifying proteins that are involved in regulation of the proliferation of ovarian carcinoma cells. Understanding factors controlling the growth of ovarian carcinoma may lead to therapeutic strategies to more effectively treat this disease.
A phase II trial of sunitinib in women with metastatic or recurrent endometrial carcinoma: a study of the Princess Margaret, Chicago and California Consortia.Castonguay V, Lheureux S, Welch S, Mackay HJ, Hirte H, Fleming G, Morgan R, Wang L, Blattler C, Ivy PS, Oza AM.
Gynecol Oncol. 2014 Aug;134(2):274-80. doi: 10.1016/j.ygyno.2014.05.016. Epub 2014 May 29.
Fractionated stereotactic radiosurgery with concurrent temozolomide chemotherapy for locally recurrent glioblastoma multiforme: a prospective cohort study.Greenspoon JN, Sharieff W, Hirte H, Overholt A, Devillers R, Gunnarsson T, Whitton A. Onco Targets Ther. 2014 Mar 24;7:485-90. doi: 10.2147/OTT.S60358.
Management of advanced or recurrent cervical cancer: chemotherapy and beyond.
Elit LM, Hirte H. Expert Rev Anticancer Ther. 2014 Mar;14(3):319-32. doi: 10.1586/14737140.2014.866041. Epub 2014 Jan 10. Review.