McMaster University

Medical Sciences
Graduate Program

Scope of Search

Radhey Gupta

Radhey Gupta

BSc, MSc, PhD
Professor

Research Interests

Broad area of research: Genetics, cell and molecular biology.

There are two main areas of research. The first concerns the cellular functions of mitochondria and heat shock proteins.


Specific problems being studied are:

  1. Subcellular distribution of mitochondial proteins in normal and disease states
  2. Mechanism of protein translocation from mitochondria to other compartments
  3. Relationship of proteins released from mitochondrial proteins under normal conditions to those during apoptosis
  4. Cellular functions of mitochondrial proteins at other sites
  5. Characterization of mutants resistant to antimitotic drugs that are affected in the major heat shock protein genes
  6. Effect of antimitotic drugs and mutant Hsp's on apoptosis.

Our second interest is in the enzyme adenosine kinase (AK), which is a key enzyme in the metabolism of adrenosine, a potent cadioprotective and neuromodulating agent.


The problems being studied are:

  1. Stucture-activity studies on AK by in vitro mutagenesis
  2. Understanding regulation of AK by pentavalent ions and other compounds
  3. Characterizing different mutants affected in AK
  4. Effect of AK mutations on the neighbouring gene for Herman-Pudlak Syndrome

Contact

McMaster University
Health Sciences Centre

telephone: (905) 525-9140 ext. 22639
email: gupta@mcmaster.ca

Program Area

Metabolism & Nutrition

Research Focus

Drug-Resistance, Molecular, Heat-shock, Proteins, Evolution, Mitochondria

Selected Publications

  • Asthma and food allergy management in chicago public schools.

    Gupta RS, Rivkina V, DeSantiago-Cardenas L, Smith B, Harvey-Gintoft B, Whyte SA. Pediatrics. 2014 Oct;134(4):729-36. doi: 10.1542/peds.2014-0402.

  • Insertion/Deletion-Based Approach for the Detection of Escherichia coli O157:H7 in Freshwater Environments.Wong SY, Paschos A, Gupta RS, Schellhorn HE. Environ Sci Technol. 2014 Oct 7;48(19):11462-70. doi: 10.1021/es502794h.
  • Enhancing TB case detection: experience in offering upfront Xpert MTB/RIF testing to pediatric presumptive TB and DR TB cases for early rapid diagnosis of drug sensitive and drug resistant TB. Raizada N, Sachdeva KS, Nair SA, Kulsange S, Gupta RS, Thakur R, Parmar M, Gray C, Ramachandran R, Vadera B, Ekka S, Dhawan S, Babre A, Ghedia M, Alavadi U, Dewan P, Khetrapal M, Khanna A, Boehme C, Paramsivan CN. PLoS One. 2014 Aug 20;9(8):e105346. doi: 10.1371/journal.pone.0105346.