Broad area of research: Genetics, cell and molecular biology.
There are two main areas of research. The first concerns the cellular functions of mitochondria and heat shock proteins.
Specific problems being studied are:
- Subcellular distribution of mitochondial proteins in normal and disease states
- Mechanism of protein translocation from mitochondria to other compartments
- Relationship of proteins released from mitochondrial proteins under normal conditions to those during apoptosis
- Cellular functions of mitochondrial proteins at other sites
- Characterization of mutants resistant to antimitotic drugs that are affected in the major heat shock protein genes
- Effect of antimitotic drugs and mutant Hsp's on apoptosis.
Our second interest is in the enzyme adenosine kinase (AK), which is a key enzyme in the metabolism of adrenosine, a potent cadioprotective and neuromodulating agent.
The problems being studied are:
- Stucture-activity studies on AK by in vitro mutagenesis
- Understanding regulation of AK by pentavalent ions and other compounds
- Characterizing different mutants affected in AK
- Effect of AK mutations on the neighbouring gene for Herman-Pudlak Syndrome