Leukocyte recruitment is a specific cascade of molecules and events designed to bring the inflammatory cells to the site of infection or injury. My research examines the role of adhesion molecules, pro-inflammatory mediators and endogenous anti-inflammatory molecules in systemic inflammation. I am specifically interested in the factors that control leukocyte recruitment and clinical therapies, such as intravenous fluid or catheter materials.
I study the in vivo responses associated with septic shock, severe infection and gastrointestinal inflammation.
I use inflammatory models such as cecal ligation and perforation and local inflammatory mediators. We currently examine the liver microcirculation, the peritoneal surface and the bladder.