Leukocyte recruitment is a specific cascade of molecules and events designed to bring the inflammatory cells to the site of infection or injury. My research examines the role of adhesion molecules, pro-inflammatory mediators and endogenous anti-inflammatory molecules in systemic inflammation. I am specifically interested in the factors that control leukocyte recruitment and clinical therapies, such as intravenous fluid or catheter materials.
I study the in vivo responses associated with septic shock, severe infection and gastrointestinal inflammation.
I use inflammatory models such as cecal ligation and perforation and local inflammatory mediators. We currently examine the liver microcirculation, the peritoneal surface and the bladder.
McMaster University
Health Sciences Centre
telephone:
(905) 525-9140 ext. 22782
email:
afoxrob@mcmaster.ca
Infection & Immunity
Inflammation, Sepsis, Liver, Endothelium, Adhesion molecules, Cytokines, Oxidative Stress
Kowalewska PM, Patrick AL, Fox-Robichaud AE. PLoS One. 2014 Sep 3;9(9):e104537. doi: 10.1371/journal.pone.0104537. eCollection 2014.
Khan M, Patrick AL, Fox-Robichaud AE; Canadian Critical Care Translational Biology Group.Biomed Res Int. 2014;2014:719853. doi: 10.1155/2014/719853. Epub 2014 May 25.