Research Interests

Leukocyte recruitment is a specific cascade of molecules and events designed to bring the inflammatory cells to the site of infection or injury. My research examines the role of adhesion molecules, pro-inflammatory mediators and endogenous anti-inflammatory molecules in systemic inflammation. I am specifically interested in the factors that control leukocyte recruitment and clinical therapies, such as intravenous fluid or catheter materials.

I study the in vivo responses associated with septic shock, severe infection and gastrointestinal inflammation.

I use inflammatory models such as cecal ligation and perforation and local inflammatory mediators. We currently examine the liver microcirculation, the peritoneal surface and the bladder.

Contact

McMaster University
Health Sciences Centre

telephone: (905) 525-9140 ext. 22782
email: afoxrob@mcmaster.ca

Program Area

Infection & Immunity

Research Focus

Inflammation, Sepsis, Liver, Endothelium, Adhesion molecules, Cytokines, Oxidative Stress

View faculty member's publications on PubMed

Selected Publications

• Syndecan-1 in the mouse parietal peritoneum microcirculation in inflammation.

  Kowalewska PM, Patrick AL, Fox-Robichaud AE. PLoS One. 2014 Sep 3;9(9):e104537. doi: 10.1371/journal.pone.0104537. eCollection 2014.

• Development of a murine model of early sepsis in diet-induced obesity.

  Khan M, Patrick AL, Fox-Robichaud AE; Canadian Critical Care Translational Biology Group.Biomed Res Int. 2014;2014:719853. doi: 10.1155/2014/719853. Epub 2014 May 25.

• Alpha-1 acid glycoprotein reduces hepatic leukocyte recruitment in murine models of either early endotoxemia or early sepsis.McCurdy TR, Patrick AL, Eltringham-Smith LJ, Bhakta V, Sheffield WP, Fox-Robichaud AE. Microcirculation. 2014 Jan;21(1):74-83. doi: 10.1111/micc.12081.