McMaster University

Medical Sciences
Graduate Program

Scope of Search

Helga Duivenvoorden

Helga Duivenvoorden

MSc, PhD
Assistant Professor

Research Interests

Investigations, basic and translational, in prostate and kidney cancer in relation to obesity and mechanisms of bone metastasis.

Wide range of techniques in molecular and cellular biology are employed:

  1. Mammalian cell culture
  2. Gene and protein expression analysis
  3. Quantitative RT-PCR
  4. Stable transfection
  5. shRNA
  6. Multiplex protein detection
  7. Western blotting
  8. Enzymography
  9. In vitro invasion and in vivo xenograft
  10. Flow cytometry
  11. Immunohistochemistry
  12. Fluorescence microscopy


McMaster University
St. Joseph’s Healthcare

Phone: (905) 522-1155
ext. 35284

Program Area

Cancer & Genetics

Research Focus

Prostate, Renal, Cancer, Invasion, Metastasis, Obesity

Selected Publications

  • Duivenvoorden WC, Paschos A, Hopmans SN, Austin RC, Pinthus JH. PLoS Endoplasmic reticulum protein ERp46 in renal cell carcinoma. One. 2014 Mar 3;9(3):e90389. doi: 10.1371/journal.pone.0090389. eCollection 2014. PMID: 2459467
  • Kleinmann N, Duivenvoorden WC, Hopmans SN, Beatty LK, Qiao S, Gallino D, Lhotak S, Daya D, Paschos A, Austin RC, Pinthus JH. Underactivation of the adiponectin-adiponectin receptor 1 axis in clear cell renal cell carcinoma: implications for progression. Clin Exp Metastasis. 2014 Feb;31(2):169-83. PMID: 24096711
  • Paschos A, Pandya R, Duivenvoorden WC, Pinthus JH. Oxidative stress in prostate cancer: changing research concepts towards a novel paradigm for prevention and therapeutics. Prostate Cancer Prostatic Dis. 2013 Sep;16(3):217-25. Review. PMID: 23670256
  • Duivenvoorden WC, Beatty LK, Lhotak S, Hill B, Mak I, Paulin G, Gallino D, Popovic S, Austin RC, Pinthus JH. Underexpression of tumour suppressor LKB1 in clear cell renal cell carcinoma is common and confers growth advantage in vitro and in vivo. Br J Cancer. 2013 Feb 5;108(2):327-33. PMID: 23322200
  • Cumming AP, Hopmans SN, Vukmirović-Popović S, Duivenvoorden WC. PSA affects prostate cancer cell invasion in vitro and induces an osteoblastic phenotype in bone in vivo. Prostate Cancer Prostatic Dis. 2011 Dec;14(4):286-94. PMID: 21826098
  • Vukmirovic-Popovic S, Escott NG, Duivenvoorden WC. Presence and enzymatic activity of prostate-specific antigen in archival prostate cancer samples. Oncol Rep. 2008 Oct;20(4):897-903. PMID: 18813833