McMaster University

Medical Sciences
Graduate Program

Scope of Search

Judah A. Denburg

Judah A. Denburg

MD, FRCP
Professor

Research Interests

Dr. Judah Denburg’s main research thrust has been to investigate the mechanisms of allergic inflammation, with particular emphasis on hemopoietic cytokines and their role in activating the differentiation and recruitment of inflammatory cells such as eosinophils, basophils and mast cells. In addition, hemopoietic progenitor phenotyping has been utilized to discover new biomarkers to predict the development of allergic disease and asthma, in several national projects undertaken by the Allergy, Genes & Environment (AllerGen) Network of Centres of Excellence, which is under Dr. Denburg’s leadership.

More Detailed Outline of Research Interests:

Dr. Denburg’s main research thrust has been to investigate the mechanisms of allergic inflammation, with particular emphasis on hemopoietic cytokines and their role in activating the differentiation and recruitment of inflammatory cells such as eosinophils, basophils and mast cells. This includes an understanding of the growth and differentiation of human basophil and eosinophil precursors, with the development of in vitro assays to monitor clinically relevant fluctuations in these cells during allergic responses. The specific diseases studied have included allergic rhinitis, nasal polyposis and asthma. These studies have established the biological importance of hemopoietic mechanisms in allergic inflammation. Currently, the focus of his research is the development of allergic disease and asthma through the study of cord blood stem cells.

Contact

McMaster University
Health Sciences Centre

telephone: (905) 521-2100 ext. 76714
email: denburg@mcmaster.ca

Program Area

Infection & Immunity

Research Focus

Eosinophils, Basophils, Hemopoiesis, Allergic Inflammation, Allergic Disease, Autoimmune Disease, Systemic Lupus Erythematosus

Selected Publications

  • Hui CC, Murphy DM, Neighbour H, Al-Sayegh M, O’Byrne S, Thong B, Denburg JA, Larché M. T cell-mediated induction of thymic stromal lymphopoietin in differentiated human primary bronchial epithelial cells. Clin Exp Allergy 44:953-964, 2014.
  • Carlsten C, Brauer M, Brinkman F, Brook J, Daley D, McNagny K, Pui M, Royce D, Takaro T, Denburg J. Genes, the environment and personalized medicine. EMBO Reports, published online June 6, 2014. This commentary summarizes the key messages resulting from discussions at the annual AllerGen NCE meeting held June 2013.
  • Reece P, Baatjes AJ, Cyr MM, Sehmi R, Denburg JA. Toll-like receptor-mediated eosinophil-basophil differentiation: autocrine signalling by granulocyte-macrophage colony-stimulating factor in cord blood haematopoietic progenitors. Immunology 139(2):256-264, 2013.
  • Weisse K, Lehmann I, Heroux D, Kohajda T, Herberth G, Röder S, von Bergen M, Borte M, Denburg J. The LINA cohort: indoor chemical exposure, circulating eosinophil/basophil (Eo/B) progenitors and early life skin manifestations. Clin Exp Allergy 42:1337-1346, 2012.
  • Reece P, Thanendran A, Crawford L, Tulic MK, Thabane L, Prescott SL, Sehmi R, Denburg JA. Maternal allergy modulates cord blood hemopoietic progenitor Toll-like receptor expression and function. J Allergy Clin Immunol 127(2): 447-453, 2011.