McMaster University

Medical Sciences
Graduate Program

Scope of Search

Darren Bridgewater

Darren Bridgewater

Associate Professor

Research Interests

Abnormal kidney development is a major cause of childhood renal failure. It arises from a failure in the fundamental processes that guide kidney development. Despite the importance of normal kidney development to human health the underlying molecular mechanisms remain poorly understood. My lab is interested in identifying the mechanisms that control kidney development. Having a better understanding of these processes will allow us to make informed hypotheses into the mechanisms that lead to disease.

More specifically my laboratory is
interested in:

  1. ß-catenin’s role in kidney development and disease
  2. Pathological mechanisms contributing to glomerular disease in patients with Schimke Immunoosseous Dysplasia (SIOD)


McMaster University
Health Sciences Centre

telephone: (905) 525-9140 ext. 20754

Program Area

Cancer & Genetics

Research Focus

ß-catenin, Kidney Development, Glomerular Disease, SIOD

Selected Publications

  • Insights into the Renal Pathogenesis in Schimke-immuno-osseous Dysplasia: A Renal Histological Characterization and Expression Analysis.Sarin S, Javidan A, Boivin F, Alexopoulou I, Svajger B, Chu S, Baradaran-Heravi A, Boerkoel CF, Rosenblum ND, Lukie D, Bridgewater D. J Histochem Cytochem. 2014 Oct 15
  • β-catenin overexpression in the metanephric mesenchyme leads to renal dysplasia genesis via cell-autonomous and non-cell-autonomous mechanisms.Sarin S, Boivin F, Li A, Lim J, Svajger B, Rosenblum ND, Bridgewater D. Am J Pathol. 2014 May
  • Penetrance of biallelic SMARCAL1 mutations is associated with environmental and genetic disturbances of gene expression.Baradaran-Heravi A, Cho KS, Tolhuis B, Sanyal M, Morozova O, Morimoto M, Elizondo LI, Bridgewater D, Lubieniecka J, Beirnes K, Myung C, Leung D, Fam HK, Choi K, Huang Y, Dionis KY, Zonana J, Keller K, Stenzel P, Mayfield C, Lücke T, Bokenkamp A, Marra MA, van Lohuizen M, Lewis DB, Shaw C, Boerkoel CF.Hum Mol Genet. 2012 Jun 1