BSc, MSc, PhD
Medical Sciences Graduate Program
The major focus of my research is on various aspects of the molecular biology of vascular disease and thrombosis. Other interests include the role of endoplasmic reticulum stress in human disease.
Specific studies include:
- Investigation of the mechanisms responsible for homocysteine-induced atherosclerosis and thrombosis.
- Examining the regulation of cell-surface tissue factor activity.
- Identifying the cellular role of dystrophin isoforms.
A wide range of molecular biological techniques are used including, RNA and DNA isolation and purification, agarose and polyacrylamide gel electrophoresis, Northern and Western blotting, polymerase chain reaction, eukaryotic and prokaryotic protein expression systems, mRNA differential display, and screening of cDNA microarrays.
Blood and Vasculature
Hyperhomocysteinemia, Atherosclerosis, Cancer, Differential Gene Expression,Endoplasmic Reticulum Stress
- Endoplasmic reticulum protein ERp46 in renal cell carcinoma.
Duivenvoorden WC, Paschos A, Hopmans SN, Austin RC, Pinthus JH. PLoS One. 2014 Mar
- Underactivation of the adiponectin-adiponectin receptor 1 axis in clear cell renal cell carcinoma: implications for progression.Kleinmann N, Duivenvoorden WC, Hopmans SN, Beatty LK, Qiao S, Gallino D, Lhotak S, Daya D, Paschos A, Austin RC, Pinthus JH.Clin Exp Metastasis. 2014 Feb
- Decreased endogenous production of hydrogen sulfide accelerates atherosclerosis.
Mani S, Li H, Untereiner A, Wu L, Yang G, Austin RC, Dickhout JG, Lhoták Š, Meng QH, Wang R.Circulation. 2013 Jun 25