McMaster University

Medical Sciences
Graduate Program

Scope of Search

Mathew Leonardi

Mathew Leonardi

Assistant Professor

Research Interests

My primary research focus is improving the non-invasive diagnosis of gynecologic pathology, particularly those that cause pelvic pain, infertility, and reduced quality of life in women and those born with female pelvic organs. Non-invasive diagnoses can be achieved by a single tool such as ultrasound or a combination of tools such as biomarkers and clinical history. The longterm goal is to reduce the necessity for diagnostic laparoscopy and reliance on a purely clinical diagnosis for gynecologic pathologies. Secondarily, improved diagnosis may allow for more appropriately targeted therapies and proper evaluation of disease progression, which are areas of academic interest for me.

Specific to endometriosis, there are about a million unanswered questions. Areas I have started to explore included the microbiome, general population and obstetrician/gynecologist awareness of diagnostic techniques, machine learning models for diagnosis using ultrasound, diagnostic accuracy of advanced ultrasound techniques. Areas I am keen to explore are how the diagnosis of endometriosis impacts wellbeing and physical outcomes, how novel techniques can be disseminated outside of academic centres, how we can sample and test bodily fluids for biomarkers to assist in diagnosis and monitoring of disease state. Other possible considerations include the effect of complementary and alternative management strategies (e.g. physiotherapy, medical cannabis, psychotherapy) on endometriosis outcomes, optimizing evidence-based practices in endometriosis and infertility, and interventional trials on specific medical or surgical management options.


McMaster University
Health Sciences Centre

telephone: 905-525-9140 x76252


Physiology and Pharmacology

Research Areas

Complex gynecology, gynecologic surgical planning and outcomes, gynecologic ultrasound, endometriosis, pelvic pain, infertility, uterine diseases (adenomyosis, fibroids), ovarian diseases (polycystic ovarian syndrome, adnexal masses), systematic reviews, meta-analyses

Selected Publications

  • Leonardi M, Espada M, Choi S, Chou D, Chang T, Smith C, Rowan K, Condous G. Transvaginal Ultrasound Can Accurately Predict the American Society of Reproductive Medicine Stage of Endometriosis Assigned at Laparoscopy. J Minim Invasive Gynecol 2020.
  • Leonardi M, Martin WP, Espada M, Georgousopoulou E, Condous G. Prevalence of negative sliding sign representing pouch of Douglas obliteration during pelvic transvaginal ultrasound for any indication. Ultrasound Obstet Gynecol 2020.
  • Leonardi M, Gibbons T, Armour M, Wang R, Glanville E, Hodgson R, Cave AE, Ong J, Tong YYF, Jacobson T, Mol B, Campbell N, Condous G. When to do surgery and when not to do surgery for endometriosis: a systematic review and meta-analysis. J Minim Invasive Gynecol 2019.
  • Leonardi M, Hicks C, El-Assaad F, El-Omar E, Condous G. Endometriosis and the microbiome: a systematic review. BJOG An Int J Obstet Gynaecol 2019: