Dr. Martin Stampfli

Division of Respirology

Martin R. Stämpfli


Professor, Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre

Associate Member, Department of Medicine, Division of Respirology




Education and Professional Standing

PhD, University of Bern (Switzerland), 1995

Dr. Martin Stämpfli is a Professor in the Department of Pathology and Molecular Medicine. His research focus is on the impact of cigarette smoke on the immune system and its implications to smoking-related diseases. Dr. Stämpfli has held several career awards including a Parker B. Francis Scholarship (USA), a CIHR New Investigator Award, and received the Respiratory 2000 International Young Investigator Award in recognition of outstanding achievement in basic research.

Research Interests

The goal of my research program is to understand how environmental and infectious agents, alone or in combination, influence innate and adaptive immune responses in the respiratory tract and the contribution of these changes to the pathogenesis of respiratory disorders such as chronic obstructive pulmonary disease (COPD). Specific focus is placedon cigarette smoke’s impact on innate and adaptive respiratory immune defense mechanisms. The goal of our research are to develop novel interventions to restore immune function and mitigate inflammation in COPD.

Selected Publications

  1. How cigarette smoke skews immune responses to promote infection, lung disease and cancer. Stämpfli MR, Anderson GP. Nat Rev Immunol. 2009 May;9(5):377-84.
  2. IL-1α/IL-1R1 expression in chronic obstructive pulmonary disease and mechanistic relevance to smoke-induced neutrophilia in mice. Botelho FM, Bauer CM, Finch D, Nikota JK, Zavitz CC, Kelly A, Lambert KN, Piper S, Foster ML, Goldring JJ, Wedzicha JA, Bassett J, Bramson J, Iwakura Y, Sleeman M, Kolbeck R, Coyle AJ, Humbles AA, Stämpfli MR.PLoS One. 2011;6(12):e28457.
  3. Immune Function and Autoimmune Disease.  32rd Surgeon General’s Report on Smoking and Health, The Health Consequences of Smoking—50 Years of Progress. Anderson GP and Stampfli MR. 2014: 545-571.
  4. Impacts of peroxisome proliferator-activated receptor-γ activation on cigarette smoke-induced exacerbated response to bacteria. Morissette MC, Shen P, Thayaparan D, Stämpfli MR. Eur Respir J. 2015 Jan;45(1):191-200.
  5. IL-17A is Elevated in End-stage COPD and Contributes to Cigarette Smoke-induced Lymphoid Neogenesis. Roos AB, Sandén C, Mori M, Bjermer L, Stampfli MR, Erjefält JS.Am J Respir Crit Care Med. 2015 Apr 6. [Epub ahead of print]

Team Members

Technical staff:
Joanna Kasinska

Post-doctoral fellows:
Yang, Gao, Abraham Roos, Gilles Vanderstocken

PhD student:
Pamela Shen

MSc student:
Ashley Beaulieu, Joshua McGrath, Danya Thayaparan

Undergraduate students:
Maria Merlano

Selected Former Trainees

Swirski, Filip, PhD,Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Robbins, Clinton, PhD,Departments of Laboratory Medicine and Pathobiology and Immunology, Peter Munk Cardiac Centre, Toronto General Research Institute, University of Toronto, Toronto, ON, Canada
Pouladi, Mahmoud, PhD, Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research and the Department of Medicine, National University of Singapore, Singapore.
Morissette, Mathieu, PhD, Faculty of Medicine, Université Laval, Québec, QC, Canada