Division of Respirology

Gail Gauvreau

BSc, MSc, PhD

Professor, Divisions of Respirology and Clinical Immunology & Allergy, Department of Medicine

 

 

 

 

 

Research Interests

My research investigates the mechanisms of allergic inflammation in human models of allergic asthma. Ongoing clinical studies examine the effects of experimental therapies on allergen-induced changes in airway physiology and inflammation, with emphasis on the activation of leukocytes known to participate in the allergic response.

More specifically, research conducted in my laboratory examines the activation of eosinophils, basophils, and their progenitors in samples from airways, blood and bone marrow. We have shown that airway epithelial cell-derived products such as TSLP are important inducers of airway inflammation, in part through the activation of basophils.

Selected Publications

  1. Gauvreau GM, El-Gammal AI, O'Byrne PM. Allergen-induced airway responses. Eur Respir J. 2015 Sep;46(3):819-31.
  2. Salter BM, Oliveria JP, Nusca G, Smith SG, Watson RM, Comeau M, Sehmi R, Gauvreau GMThymic stromal lymphopoietin activation of basophils in patients with allergic asthma is IL-3 dependent. J Allergy Clin Immunol. 2015 Dec;136(6):1636-44.
  3. Gauvreau GM, O'Byrne PM, Boulet L-P, Wang D, Cockcroft DW, Bigler J, Fitzgerald JM, Boedigheimer M, Davis BE, Dias C, Gorski K, Smith L, Bautista E, Comeau MR, Leigh R, Parnes JR. Effects of an anti-TSLP antibody on allergen-induced asthmatic responses. N Engl J Med. 2014 May 29;370(22):2102-10.
  4. Gauvreau GM, Harris JM, Boulet LP, Scheerens H, Fitzgerald JM, Putnam WS, Cockcroft DW, Davis BE, Leigh R, Zheng Y, Dahlén B, Wang Y, Maciuca R, Mayers I, Liao XC, Wu LC, Matthews JG, O'Byrne PM. Targeting membrane-expressed IgE B cell receptor with an antibody to the M1 prime epitope reduces IgE production. Sci Transl Med. 2014 Jul 2;6(243):243ra85.