Division of Hematology & Thromboembolism

Donald M. Arnold

M.D., MSc, FRCP(C)

Associate Professor, Division of Hematology and Thromboembolism,
Department of Medicine



Education and Professional Standing

Dr. Arnold obtained his medical degree from McGill University in 1997 and his Master’s in Clinical Epidemiology from McMaster University in 2006. He completed his residency training in Internal Medicine at the Sir Mortimer B. Davis Jewish General Hospital in Montreal in 2001, Hematology at McMaster University in 2003 and Transfusion Medicine with the Canadian Blood Services (CBS) in 2005. He has completed a Fellowship in Transfusion Science funded jointly by the Canadian Institutes for Health Research and CBS. Dr. Arnold is an assistant professor in the department of Medicine at McMaster University as of July 2007.

Research Interests

Dr. Arnold’s research interests are in platelet disorders with a focus on clinical trials. He is spearheading a new Canadian multi-centered pilot trial of rituximab in ITP with plans for the larger phase III trial already underway. Other research interests include the optimal use of platelet transfusions in critically ill patients and transfusion reactions.

Selected Publications

  1. Arnold, DM, Lim W. The use and abuse of surrogate endpoints in clinical research in
    transfusion medicine. Transfusion 2008 May 23 (Epub ahead of print).
  2. Heddle NM, Arnold DM, Boye D, Webert KE, Resz I, Dumont LJ. Comparing the efficacy and safety of apheresis and whole blood derived platelet transfusions: A systematic review. Transfusion 2008 May 12 (Epub ahead of print).
  3. Arnold DM, Kelton JG. Current Options for the Treatment of Idiopathic Thrombocytopenic Purpura. Semin Hematol 2007; 44(suppl 5):S12-S23
  4. Arnold DM. The Science of Systematic Reviews. Transfusion. 2007 Aug;47(8):1347-9
  5. Moore JC, Arnold DM, Leber BF, Clare R, Molnar GJ, Kelton JG. Intravenous Immunoglobulin as an Adjunct to Plasma Exchange for the Treatment of Chronic Thrombotic Thrombocytopenic Purpura. Vox Sang. 2007 Aug;93(2):173-5
  6. Arnold DM, Blajchman MA, DiTomasso J, Kulczycki M, Keith PK. Passive Transfer of Peanut Hypersensitivity by Fresh Frozen Plasma. Arch Intern Med. 2007 Apr 23;167(8):853-4.
  7. Arnold DM, Donahoe L, Clarke FJ, Tkaczyk AJ, Heels-Ansdell D,Zytaruk N, Cook RJ, Webert KE, McDonald E, Cook DJ. Bleeding during critical illness: A prospective cohort study using a new measurement tool. Clin Invest Med 2007;30:E93-E102.
  8. Arnold DM, Dentali F, Crowther MA, Meyer RM, Cook RJ, Sigouin C, Fraser GA, Lim W, and Kelton JG. Systematic Review: Efficacy and Safety of Rituximab for Adults with Idiopathic Thrombocytopenic Purpura. Annals of Internal Medicine. 2007;146:25-33.

Collective Works and Book Chapters

Arnold D, Hume H, Popovsky MA ed. Hypotensive transfusion reactions, Transfusion Reactions, 3rd ed. Bethesda, MD: AABB Press, 2007: 251 – 273.

Arnold DM & Warkentin TE. Thrombocytopenia and Thrombocytosis in Critical Care. In Trauma: Resuscitation, Anesthesia, and Critical Care, 2007. Publisher: Marcel Dekker Inc., New York.