Division of Gastroenterology

Frances Tse


Associate Professor, Division of Gastroenterology, Department of Medicine

Chief of Service, Gastroenterology





Academic Biography

Dr. Frances Tse is an Associate Professor and Chief of Service for Gastroenterology at Hamilton Health Sciences. After receiving her MD at the University of Calgary, she completed her Internal Medicine residency, Gastroenterology Fellowship, and MSc in Clinical Epidemiology & Biostatistics at McMaster University. She went on to complete two additional years of fellowship in Advanced Therapeutic Endoscopy (EUS & ERCP) at McGill University in Montreal. She has been on staff at McMaster University since 2005. She was the Program Director for the Adult Gastroenterology Training Program from 2009-2015.

Her clinical, research and medical education efforts are focused in Therapeutic Endoscopy.
She specializes in pancreatic and biliary disorders with particular expertise in therapeutic endoscopic retrograde cholangiopancreatography (ERCP), endoscopic ultrasound (EUS) including EUS-guided fine needle aspiration (FNA) / fine needle biopsy (FNB) of mass lesions and EUS-guided interventions (celiac plexus block / neurolysis, drainage of pancreatic pseudocysts, etc.), as well as endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) of complex large polyps.

Her research interests lie primarily in the area of post-ERCP pancreatitis. She has published a number of systematic reviews and meta-analyses in this area. She serves as a methodologist in the guideline development process for the Canadian Association of Gastroenterology (CAG). She has been involved in the process of integrating the GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach in the development of high quality, evidence-based clinical guidelines in many areas including inflammatory bowel disease, wireless capsule endoscopy, dysphagia, colorectal cancer screening, bile acid diarrhea, and upper gastrointestinal bleeding for the CAG. She is the lead for the CAG Practice Affairs Committee. She is an Editor for the Cochrane Upper GI and Pancreatic Diseases Group and the Journal of the Canadian Association of Gastroenterology (JCAG). She is also a certified faculty for the Canadian Association of Gastroenterology’s Skills Enhancement for Endoscopy (SEE™) Program that addresses gaps in the quality of endoscopy skills through Train the Colonoscopy Skills Improvement (CSI) and Train-the-Endoscopy-Training (TET) courses.

Dr. Tse has received several honors / awards during her career including the Watson Buchanan Clinician Educator Award, teaching award for GI residents, and the American Society for Gastrointestinal Endoscopy (ASGE) Research & Outcomes & Effectiveness Award.

Selected Publications

  1. Enns RA, Hookey L, Armstrong D, Bernstein CN, Heitman SJ, Teshima C, Leontiadis GI, Tse F, Sadowski D. Clinical Practice Guidelines for the Use of Video Capsule Endoscopy. Gastroenterology. 2017 Feb;152(3):497-514.
  2. Tse F, Yuan Y, Moayyedi P, Leontiadis GI, Barkun A Tse F, Yuan Y, Moayyedi P, Leontiadis GI, Barkun AN. Double-guidewire technique in difficult biliary cannulation for the prevention of post-ERCP pancreatitis: a systematic review and meta-analysis. Endoscopy. 2017 Jan;49(1):15-26.
  3. Forbes N, Cooray M, Al-Dabbagh R, Yuan Y, Tse F, Liu LW, Xenodemetropoulos T. Domperidone Prescribing Practices Exposed Patients to Cardiac Risk despite a "Black Box" Warning: A Canadian Tertiary Care Center Study. Can J Gastroenterol Hepatol. 2016;2016:2937678.
  4. Tse F, Yuan Y, Bukhari M, Leontiadis GI, Moayyedi P, Barkun A. Pancreatic duct guidewire placement for biliary cannulation for the prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. Cochrane Database Syst Rev. 2016 May 16;(5):CD010571.
  5. Nguyen GC, Seow CH, Maxwell C, Huang V, Leung Y, Jones J, Leontiadis GI, Tse F, Mahadevan U, van der Woude CJ; IBD in Pregnancy Consensus Group; Canadian Association of Gastroenterology. The Toronto Consensus Statements for the Management of Inflammatory Bowel Disease in Pregnancy. Gastroenterology. 2016 Mar;150(3):734-757.
  6. Alhazzani W, Al-Shamsi HO, Greenwald E, Radhi J, Tse F. Chronic abdominal pain secondary to mesenteric panniculitis treated successfully with endoscopic ultrasonography-guided celiac plexus block: A case report. World J Gastrointest Endosc. 2015 May 16;7(5):563-6.
  7. Anglin R, Yuan Y, Moayyedi P, Tse F, Armstrong D, Leontiadis GI. Risk of upper gastrointestinal bleeding with selective serotonin reuptake inhibitors with or without concurrent nonsteroidal anti-inflammatory use: a systematic review and meta-analysis. Am J Gastroenterol. 2014 Jun;109(6):811-9.
  8. Tse F, Yuan Y, Leontiadis GI. The role of endoscopic retrograde cholangiopancreatography in acute pancreatitis. Am J Gastroenterol. 2014 Mar;109(3):443-4.
  9. Yuan Y, Ford AC, Khan KJ, Gisbert JP, Forman D, Leontiadis GI, Tse F, Calvet X, Fallone C, Fischbach L, Oderda G, Bazzoli F, Moayyedi P. Optimum duration of regimens for Helicobacter pylori eradication. Cochrane Database Syst Rev. 2013 Dec 11;(12):CD008337.
  10. Razik R, Cino M; Canadian Gastroenterology Program Directors, Nguyen GC. Employment prospects and trends for gastroenterology trainees in Canada: a nationwide survey. Can J Gastroenterol. 2013 Nov;27(11):647-52.
  11. Alkhiari R, Jacob D, Kassam Z, Abu Zaghlan O, Tse F. Closure of a percutaneous endoscopic gastrostomy-associated nonhealing gastrocutaneous fistula using endoscopic hemoclips. Can J Gastroenterol. 2013 Sep;27(9):501-2.
  12. Xiong X, Barkun AN, Waschke K, Martel M; Canadian Gastroenterology Training Program Directors. Current status of core and advanced adult gastrointestinal endoscopy training in Canada: Survey of existing accredited programs. Can J Gastroenterol. 2013;27(5):267-72.
  13. Tse F, Yuan Y, Moayyedi P, Leontiadis GI. Guidewire-assisted cannulation of the common bile duct for the prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. Cochrane Database Syst Rev. 2012 Dec 12;12:CD009662.
  14. Jones DJ, Barkun AN, Lu Y, Enns R, Sinclair P, Martel M, Gralnek I, Bardou M, Kuipers EJ, Sung J; International Consensus Upper Gastrointestinal Bleeding Conference Group.  Conflicts of interest ethics: silencing expertise in the development of international clinical practice guidelines. Ann Intern Med. 2012 Jun 5;156(11):809-16, W-283.
  15. Tse F, Yuan Y. Early routine endoscopic retrograde cholangiopancreatography strategy versus early conservative management strategy in acute gallstone pancreatitis. Cochrane Database Syst Rev. 2012 May 16;(5):CD009779.
  16. Greenspoon J, Barkun A, Bardou M, Chiba N, Leontiadis GI, Marshall JK, Metz DC, Romagnuolo J, Sung J; International Consensus Upper Gastrointestinal Bleeding Conference Group. Management of patients with nonvariceal upper gastrointestinal bleeding. Clin Gastroenterol Hepatol. 2012 Mar;10(3):234-9.
  17. Leontiadis GI, Tse F, Howden CW. Antiplatelet therapy in patients with atherosclerotic coronary artery disease undergoing elective endoscopic gastrointestinal procedures. Key messages for clinical practice. Pol Arch Med Wewn. 2010 Apr;120(4):143-7.
  18. Barkun AN, Bardou M, Kuipers EJ, Sung J, Hunt RH, Martel M, Sinclair P; International Consensus Upper Gastrointestinal Bleeding Conference Group. International consensus recommendations on the management of patients with nonvariceal upper gastrointestinal bleeding. Ann Intern Med. 2010 Jan 19;152(2):101-13.
  19. Tse F, Liu L, Barkun AN, Armstrong D, Moayyedi P. EUS: a meta-analysis of test performance in suspected choledocholithiasis. Gastrointest Endosc. 2008 Feb;67(2):235-44.
  20. Tse F, Barkun JS, Barkun AN. The elective evaluation of patients with suspected choledocholithiasis undergoing laparoscopic cholecystectomy. Gastrointest Endosc. 2004 Sep;60(3):437-48. Review.