Division of Gastroenterology

Premysl Bercik


Associate Professor, Division of Gastroenterology, Department of Medicine

Richard Hunt-AstraZeneca Chair in Gastroenterology

Education and Professional Standing

Dr. Bercik is an Associate Professor of Medicine, Division of Gastroenterology at McMaster University and consultant gastroenterologist at Hamilton Health Sciences in Hamilton Ontario. He is director of Complex Motility and Celiac Clinics at McMaster University.

Dr. Bercik graduated as MD from Charles University, Prague, Czechoslovakia. He obtained his doctorate degree from University of Lausanne, Switzerland, where he studied neural control of gastrointestinal motility. He did his postdoctoral fellowship at McMaster University focusing on animal models of functional gastrointestinal diseases. His basic and clinical research, funded by CIHR and NIH, investigates the role of intestinal bacteria in gut-brain axis signaling, and its relevance to functional gastrointestinal and gluten-related disorders. He has published over 90 peer-reviewed papers.

Clinical Interests

  • Functional gastrointestinal diseases
  • Gastrointestinal motility disorders (dysphagia, gastroparesis, constipation)
  • Celiac disease and other gluten related disorders

Selected Publications

  1. De Palma G, Blennerhassett P, Lu J, Deng Y, Park AJ, Green W, Denou E, Silva MA, Santacruz A, Sanz Y, Surette MG, Verdu EF, Collins SM, Bercik P. Microbiota and host determinants of behavioural phenotype in maternally separated mice. Nature Communications 2015; 6:7735.
  2. Pinto-Sanchez MI, Ford AC, Avila CA, Verdu EF, Collins SM, Morgan D, Moayyedi P, Bercik P. Anxiety and depression increase in a stepwise manner in parallel with multiple FGIDs and symptom severity and frequency. The American Journal of Gastroenterology 2015; 110(7): 1038-48.
  3. Leffler DA, Kelly CP, Green PH, Fedorak RN, DiMarino A, Perrow W, Rasmussen H, Wang C, Bercik P, Bachir NM, Murray JA. Larazotide acetate for persistent symptoms of celiac disease despite a gluten-free diet: a randomized controlled trial. Gastroenterology 2015; 148(7): 1311-9.
  4. De Palma G, Lynch MD, Lu J, Dang VT, Deng Y, Jury J, Umeh G, Miranda PM, Pigrau Pastor M, Sidani S, Pinto-Sanchez MI, Philip V, McLean PG, Hagelsieb MG, Surette MG, Bergonzelli GE, Verdu EF, Britz-McKibbin P, Neufeld JD, Collins SM, Bercik P. Transplantation of fecal microbiota from patients with irritable bowel syndrome alters gut function and behavior in recipient mice. Science Translational Medicine 2017; 9(379).
  5. Pinto-Sanchez MI, Hall GB, Ghajar K, Nardelli A, Bolino C, Lau JT, Martin FP, Cominetti O, Welsh C, Rieder A, Traynor J, Gregory C, De Palma G, Pigrau M, Ford AC, Macri J, Berger B, Bergonzelli G, Surette MG, Collins SM, Moayyedi P, Bercik P. Probiotic Bifidobacterium longum NCC3001 reduces depression scores and alters brain activity: A pilot study in patients with Irritable Bowel Syndrome. Gastroenterology 2017; 153(2): 448-459.