Dr. Maureen Meade

Division of Critical Care

Maureen Meade

MD, FRCPC, MSc (Epid)

Professor, Department of Medicine, Clinical Epidemiology & Biostatistics

Director, Canada-DONATE Research Program

Co-Chair, ACCADEMY (Academy of Critical Care: Development, Evaluation, and Methodology)

Staff Physician, Hamilton Health Sciences

Administrative Assistant: Laurel Grainger
905.525.9140 X22900

Education and Professional Standing

  • Bachelor of Science, University of Ottawa: 1986
  • Medical Degree (MDCM), McGill University: 1990
  • Internal Medicine, University of Toronto: 1990-1993
  • Academic General Internal Medicine Fellowship: 1993-1994
  • Masters of Science (Health Research Methods), McMaster University: 1993-1995
  • Critical Care Fellowship, University of Toronto: 1995-1996
  • Critical Care Research Fellowship, University of Toronto: 1996-1998

Research Interests

Dr. Meade recently launched a program of research in deceased organ donation and is the director of the Canada-DONATE research program.   Central to this research is a national prospective observational study of deceased donation practices at high-volume donation institutions across Canada.  The purpose is to build a national research platform that will support future clinical trials and address various pragmatic, methodologic and ethical challenges unique to research in this field.  In the context of the observational study, Dr. Meade and her collaborators are advancing research consent models; evaluating the suitability of provincial data for research purposes; developing a generic outcome measurement of graft function specifically for donation research; and creating knowledge translation tools for clinical and research purposes.  Other initiatives include systematic reviews, surveys, and qualitative research.  This research has engaged the collaboration of intensive care physicians, transplant physicians and other key stakeholders including the Trillium Gift of Life Network of Ontario, Transplant Quebec, Canadian Blood Services, the Canadian National Transplant Research Program and the Canadian Critical Care Trials Group.

Dr. Meade has also spearheaded 4 randomized clinical trials evaluating lung-protective ventilation strategies (inhaled nitric oxide, low tidal volume ventilation, lung open ventilation and high frequency oscillation) for patients with acute respiratory distress syndrome (ARDS).  Largely funded by the Canadian Institutes for Health Research, many have been international in scope and practice-changing.  These trials have been published in NEJM, JAMA, and the Am J Respir Crit Care Med.  Dr. Meade’s ARDS research also includes physiologic studies, surveys, provincial and national observational studies, systematic reviews, individual patient data meta-analysis, and international guidelines.

Activities and Contributions  

Dr. Meade is a clinician-researcher at McMaster University. She is a member of the CLARITY (Clinical Advances through Research and Information Translation) Research Group.  Dr. Meade has had a substantial influence on evidence-based decision-making in critical care worldwide through her research, lectures, and workshops.

Dr. Meade practices critical care medicine at Hamilton Health Sciences – General Site where she supervises medical students, residents and fellows from numerous specialties.  She also supervises both Masters and PhD graduate students in the Health Research Methodology Program.

Dr. Meade is very active in fostering research in critical care. She and Dr Alison Fox-Robichaud supervise residents/fellows in critical care through regular ‘Research in Progress’ meetings.  As well, she and Dr Deborah Cook Co-Chair an ICU special interest group called ACCADEMY (Academy of Critical Care: Development, Evaluation, and Methodology) for ICU clinicians registered in formal research methodology training.

Selected Publications  

  1. Oczkowski SJ, Centofanti JE, Durepos P, Arseneau E, Kelecevic J, Cook DJ, Meade MO. Organ donation in the ICU: A document analysis of institutional policies, protocols, and order sets. Intensive and Crit Care Nursing. 2018.
  2. D’Aragon F, Dhanani S, Lamontagne F, Cook DJ, Burns K, Akhtar A, Chassé M, Frenette AJ, Keenan S, Lize JF, Kutsogiannis DJ. Meade MO. Canada-DONATE study protocol: a prospective national observational study of the medical management of deceased organ donors. BMJ Open. 2017; 7(9).
  3. Meade MO, Cook DJ, Guyatt GH, Slutsky AS, Arabi YM, Cooper DJ, Davies AR, Hand LE, Zhou Q, Thabane L, Austin P, Lapinsky S, Baxter A, Russell J, Skrobik Y, Ronco JJ, Stewart TE, for the Lung Open Ventilation Study Investigators. Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome. JAMA 2008; 299(6): 637-645.
  4. D'Aragon F, Belley-Cote E, Agarwal A, Frenette AJ, Lamontagne F, Guyatt G, Dhanani S, Meade MO. Effect of corticosteroid administration on neurologically deceased organ donors and transplant recipients: a systematic review and meta-analysis. BMJ Open. 2017;7(6)
  5. Foroutan F, Alba AC, Guyatt G, Posada JD, Hing NN, Arseneau E, Meade M, Hanna S, Badiwala M, Ross H. Predictors of 1-year mortality in heart transplant recipients: a systematic review and meta-analysis. Heart. 2017.
  6. Guyatt G, Rennie D, Meade M, Cook D. Users' guides to the medical literature. McGraw-Hill Medical; 2015.
  7. Briel M, Meade M, Mercat A, Brower RG, Talmor D, Walter SD, Slutsky AS, Pullenayegum E, Zhou Q, Cook D, Brochard L. Higher vs lower positive end-expiratory pressure in patients with acute lung injury and acute respiratory distress syndrome: systematic review and meta-analysis. JAMA. 2010;303(9):865-73.
  8. Kumar A, Zarychanski R, Pinto R, Cook DJ, Marshall J, Lacroix J, Stelfox T, Bagshaw S, Choong K, Lamontagne F, Turgeon AF. Meade MO et al.  Critically ill patients with 2009 influenza A (H1N1) infection in Canada. JAMA. 2009;302(17):1872-9.
  9. Meade MO, Cook DJ, Guyatt GH, Slutsky AS, Arabi YM, Cooper DJ, Davies AR, Hand LE, Zhou Q, Thabane L, Austin P. Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JAMA. 2008;299(6):637-45.
  10. Meade MO, Jacka MJ, Cook DJ, Dodek P, Griffith L, Guyatt GH for the Canadian Critical Care Trials Group. A survey of interventions for the prevention and treatment of the acute respiratory distress syndrome. Crit Care Med 2004; 32:946-954.
  11. Meade M, Guyatt G, Cook D, Griffith L, Sinuff T, Kergl C, Mancebo J, Esteban A, Epstein S. Predicting success in weaning from mechanical ventilation. Chest. 2001;120(6):400S-24S.
  12. Stewart TE, Meade MO, Cook DJ, et al. A pressure and volume limited ventilation strategy (PLVS) for patients at high risk for ARDS. New Engl J Med 1998; 338:355-361.

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