McMaster University

McMaster University

Disinfection of human skin allografts in tissue banking

We are pleased to share with you a recent publication in Cell and Tissue Banking. This publication is entitled "Disinfection of human skin allografts in tissue banking: a systematic review report".

Please find access to the full-version of the article click here.

Johnston C, Callum J, Mohr J, Duong A, Garibaldi A, Simunovic N, Ayeni OR, Bioburden Steering Committee and Skin Working group. Disinfection of human skin allografts in tissue banking: a systematic review report. Cell Tissue Bank. 2016 Aug 13. [Epub ahead of print]


The use of skin allografts to temporarily replace lost or damaged skin is practiced worldwide. Naturally occurring contamination can be present on skin or can be introduced at recovery or during processing. This contamination can pose a threat to allograft recipients. Bacterial culture and disinfection of allografts are mandated, but the specific practices and methodologies are not dictated by standards. A systematic review of literature from three databases found 12 research articles that evaluated bioburden reduction processes of skin grafts. The use of broad spectrum antibiotics and antifungal agents was the most frequently identified disinfection method reported demonstrating reductions in contamination rates. It was determined that the greatest reduction in the skin allograft contamination rates utilized 0.1 % peracetic acid or 25 kGy of gamma irradiation at lower temperatures.

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