McMaster University

Forsythe Lab

Scope of Search

Recent Publications

1: Leclercq S, Mian FM, Stanisz AM, Bindels LB, Cambier E, Ben-Amram H, Koren O, Forsythe P, Bienenstock J. Low-dose penicillin in early life induces long-term changes in murine gut microbiota, brain cytokines and behavior. Nat Commun. 2017 Apr 4;8:15062. doi: 10.1038/ncomms15062.

2: Khambati I, Han S, Pijnenburg D, Jang H, Forsythe P. The bacterial quorum-sensing molecule, N-3-oxo-dodecanoyl-L-homoserine lactone, inhibits mediator release and chemotaxis of murine mast cells. Inflamm Res. 2017 Mar;66(3):259-268. doi: 10.1007/s00011-016-1013-3.


3: Bharwani A, Mian MF, Surette MG, Bienenstock J, Forsythe P. Oral treatment with Lactobacillus rhamnosus attenuates behavioural deficits and immune changes in chronic social stress.BMC Med. 2017 Jan 11;15(1):7. doi: 10.1186/s12916-016-0771-7.


4:Forsythe P, Kunze W, Bienenstock J. Moody microbes or fecal phrenology: what do we know about the microbiota-gut-brain axis? BMC Med. 2016 Apr 19;14(1):58. doi: 10.1186/s12916-016-0604-8.


5: Szklany K, Ruiter E, Mian F, Kunze W, Bienenstock J, Forsythe P, Karimi K. Superior Cervical Ganglia Neurons Induce Foxp3+ Regulatory T Cells via Calcitonin Gene-Related Peptide. PLoS One. 2016 Mar 29;11(3):e0152443. doi: 10.1371/journal.pone.0152443.


6:Janik R, Thomason LA, Stanisz AM, Forsythe P, Bienenstock J, Stanisz GJ. Magnetic resonance spectroscopy reveals oral Lactobacillus promotion of increases in brain GABA, N-acetyl aspartate and glutamate. Neuroimage. 2016 Jan 15;125:988-95. doi: 10.1016/j.neuroimage.2015.11.018.


7: Bharwani A, Mian MF, Foster JA, Surette MG, Bienenstock J, Forsythe P. Structural & functional consequences of chronic psychosocial stress on the microbiome & host. Psychoneuroendocrinology. 2016 Jan;63:217-27. doi: 10.1016/j.psyneuen.2015.10.001.


8: Bienenstock J, Kunze W, Forsythe P. Microbiota and the gut-brain axis. Nutr Rev. 2015 Aug;73 Suppl 1:28-31. doi: 10.1093/nutrit/nuv019.


9: Forsythe P. Microbes taming mast cells: Implications for allergic inflammation and beyond. Eur J Pharmacol. 2016 May 5;778:169-75. doi: 10.1016/j.ejphar.2015.06.034.


10: Castillo-Courtade L, Han S, Lee S, Mian FM, Buck R, Forsythe P. Attenuation of food allergy symptoms following treatment with human milk oligosaccharides in a mouse model. Allergy. 2015 Sep;70(9):1091-102. doi: 10.1111/all.12650.


11: Al-Nedawi K, Mian MF, Hossain N, Karimi K, Mao YK, Forsythe P, Min KK, Stanisz AM, Kunze WA, Bienenstock J. Gut commensal microvesicles reproduce parent bacterial signals to host immune and enteric nervous systems. FASEB J. 2015 Feb;29(2):684-95. doi: 10.1096/fj.14-259721.


12: Forsythe P. The parasympathetic nervous system as a regulator of mast cell function. Methods Mol Biol. 2015;1220:141-54. doi: 10.1007/978-1-4939-1568-2_9.


13: Forsythe P, Bienenstock J, Kunze WA. Vagal pathways for microbiome-brain-gut axis communication. Adv Exp Med Biol. 2014;817:115-33. doi: 10.1007/978-1-4939-0897-4_5.


14: Forsythe P. Probiotics and lung immune responses. Ann Am Thorac Soc. 2014 Jan;11 Suppl 1:S33-7.