The Lancet and the New England Journal of Medicine (NEJM) have accepted papers from Dr Sonia Anand, with Drs Stu Connolly and John Eikelboom. These papers stem from the COMPASS study, which is an international study from 33 countries and over 27 000 participants.
The NEJM paper has shown that rivaroxaban (a.k.a. Xarelto) and aspirin in combination are more effective in preventing heart attacks, strokes, and death (from heart disease). The difference (aspirin vs aspirin and rivaroxaban) was so clear, that they stopped the trial early.
This same combination of drugs (aspirin and rivaroxaban) was shown in the Lancet paper to reduce damage to limbs (loss of limb or reduced blood flow) by 46% and reduce heart attacks, stroke, and death from heart disease by 28%.
Rivaroxaban was not more effective than aspirin on its own. The use of rivaroxaban (on its own or with aspirin) increased major bleeding, but not fatal or critical organ bleeding.
Dr Sonia Anand has published a paper on gestational diabetes risk in South Asian women in Ontario. In the START prospective cohort, 36.3% of women had gestational diabetes. Factors that were associated with gestational diabetes included maternal age, family history of diabetes, prepregnancy weight, and diet quality. The modifiable risk factors (prepregnancy weight/BMI and diet) accounted for 37% of the population attributable risk of gestational diabetes. McMaster also featured this paper in its news.
We had the pleasure of having Dr John Ioannidis here as the fifth annual Chanchlani Global Health Research Award Lecturer on February 6. While here, he presented his thoughts on currently used study methodologies, and their merits or dangers. If you were unable to see this lecture in person, you may view it below:
It is with our deepest regrets that we learn of the passing of Hans Rosling. We had the pleasure of having him here as the second annual Chanchlani Global Health lecturer and award winner in 2014, and all valued the opportunity to meet him. We will miss his data-driven insights into global health. Here is an obituary from the Guardian.
Dr John Ioannidis is the recipient of the fifth annual Chanchlani Global Health Research Award. He will present his lecture Improving Research Practices: A Global Challenge on Monday February 6, 2017. For more details, see this article from the McMaster Global Health Office.
December 7, 2016
MICYRN Member Organizations– A Closer Look
With exceptional work taking place at the 20 organizations that make up the MICYRN collaborative, the quarterly newsletter will now include a new feature exploring their research and achievements. This issue features the Department of Pediatrics at McMaster University, a long-standing member of MICYRN that played a key role in the early days of the network’s formation.
The department has strong research, education and clinicalprograms with more than 200 faculty comprised of clinician-educators, clinician scientists and basic scientists. Research conducted within the Department of Pediatrics is supported by the Associate Chair (Research), Dr. Anthony Chan, a research services specialist, and two statisticians with research design expertise, and several wet and dry laboratory research facilities. Child health research in the department is categorized into five thematic programs, including Determinants of Health and Disease, Mechanism of Disease and Disability, Innovative Management of Childhood Disease, Health and Quality of Life Outcomes, and Knowledge Translation and Education. A number of the department’s investigators have benefited from linking to MICYRN, most recently Katherine Morrison (TeamABC3, CIHR Bariatric Care grant), Deborah Sloboda and Stephanie Atkinson (Hugs for HEALTH: Healthy Bugs for Healthy Babies, CIHR DOHaD Team grant), and Jan Willem Gorter (CHILD-BRIGHT, CIHR SPOR Chronic Diseases grant).
One of the department’s leading research foci is developmental origins of health and disease (DOHaD) using epidemiological, clinical trial and basic animal research.
McMaster researchers have taken a national lead on optimizing the use of study data through collaborative research using software and metadata facilities. With a network start-up grant from MICYRN in 2008, Dr. Stephanie Atkinson, (McMaster University professor and current MICYRN board chair) led a symposia on Birth Cohort Studies: Findings, best methods and gene studies, which led to the recent partnership between MICYRN and Maelstrom Research (McGill), and highly collaborative interactions with pregnancy and birth cohort researchers across Canada.
MICYRN has provided the investigators in-kind support towards the objective of building a virtual infrastructure to connect Canadian pregnancy and birth cohort studies to share study designs, methodologies and eventual harmonization of data.
In March, the CIHR DOHaD Registry – Research Advancement through Cohort Cataloguing and Harmonization (ReACH) was approved for $1.3M in funding distributed over five years.
The ReACH initiative will address the issue that individual studies often do not have the statistical power, specific data items, or appropriate design needed to fully support the current and upcoming needs of cutting-edge research. It will provide resources (a comprehensive web-based catalogue and harmonization platform) to the Canadian research community to optimize the use of existing Canadian cohort data and samples, and leverage national and international DOHaD research collaborations. A small portion of funds will come to MICYRN’s coordinating centre for logistical support. Several of the funded research projects in DOHaD have also been provided in-kind support by MICYRN for knowledge translation.
Visit the McMaster UniversityDepartment of Pediatrics research page for more news on recent accomplishments.
Published: February 29, 2016
Vikram Patel's vision of mental health for all "is one that we should all celebrate," said Dr. Tina Chanchlani, who presented the Chanchlani Global Health Research Award to this year's recipient on February 23, 2016 at the 4th annual award and lecture.
Chanchlani's father, philanthropist Vasu Chanchlani who passed away in 2014, and her mother, Dr. Jaya Chanchlani, created the award with McMaster in 2012 to honour an outstanding scientist who has made a significant impact in the area of global health.
As Chanchlani noted, Patel is a "psychiatrist, researcher, author, and professor who has dedicated his life's work to making a positive difference in the field of global health and giving voice to those who are marginalized."
He delivered his talk "The Black Dog: Why We Don’t Care" to a packed lecture hall. The dynamic presentation shed light on the issue of depression and mental illnesses, which are among the leading causes of disability around the world. The World Health Organization (WHO) estimates that nearly four to five hundred million people are affected by mental illness.
"We were delighted to recognize Vikram Patel and his contributions to the area of global mental health," says Andrea Baumann, director of the Global Health program. "The stigma of mental health is a very real issue, and it needs to be addressed, especially considering the fact that depression is a leading cause of the global burden of disease."
Patel is co-founder and former Director of the Centre for Global Mental Health at the London School of Hygiene and Tropical Medicine (LSHTM). He is also Co-Director of the Centre for Control of Chronic Conditions for the Public Health Foundation of India, as well as the co-founder and a member of the Managing Committee of the NGO Sangath.
Dr Vikram Patel, MRCPsych PhD FMedSci
Although depression is one of the leading causes of the global burden of disease, there is little action by global or national policy makers to implement the interventions which are known to help people recover. This lecture will consider the assumptions and myths which underpin this inaction and the knowledge base which addresses these. The lecture will propose the necessary steps for the global health community to address one of the most neglected health conditions of our times.
The award ceremony will be held after the lecture on Tuesday February 23, 2016
SANSAR is a charitable organization whose mission is to promote the health of South Asians through community awareness, educational programs and research. The SANSAR Young Investigator Award is meant to provide recognition and support to an outstanding young investigator whose activities are focused on the health of South Asians.
Professor Ab Osterhaus, PhD Professor of Virology in Rotterdam, Utrecht, and Hannover.
Ab Osterhaus is an award-winning scientific researcher and principal investigator for numerous major scientific projects. As Professor of Virology in Rotterdam, Utrecht, and Hannover, he ran the virology diagnostic and research labs at Erasmus MC and is currently establishing new One Health Institutes in Utrecht and Hannover.
He has discovered over 50 new viruses in humans and animals, and his work has enabled health authorities including the WHO to combat outbreaks like SARS, MERS, and the avian influenza. As Chief Scientific Officer at Viroclinics Biosciences BV, Osterhaus leads effective testing and refining of preventive, therapeutic, and diagnostic tools.
Osterhaus mentors many students, holds several key patents, and has authored more than 1,100 papers in peer-reviewed journals. He firmly believes scientists have a role to play in translating their knowledge for the benefit and protection of society.
The award ceremony was held on February 25, 2015 in Health Sciences Centre at McMaster University.
We are all deeply saddened by the passing of Mr. Vasudev Chanchlani on September 7, 2014 His passion for medical research, higher education, and celebrating Canada’s multicultural diversity was evident in his unwavering support of the Chanchlani Research Centre. His passion will continue to influence our research, and we are ever so grateful for his and his family's support of our mission.
Dr. Hans Rosling, PhD, MD Professor of International Health, Karolinska Institute, Co-founder & Chairman, Gapminder Foundation
The award ceremony was held on February 24, 2014 in Health Sciences Centre at McMaster University
Read the synopsis of the Women's Health Symposium which was held on May 10, 2013 in Boston.
Click on the link below to read about this prestigous award.
The Chanchlani Global Health Research Award was created by the Chanchlani Family and McMaster University in 2012 to recognize a leading scholar in the area of Global Health. The Scholar will be selected based on his or scholarly contributions to Global Health. Each year a discipline within Global Health (i.e. Determinants of Health, Policy Development, Innovative Solutions) will be chosen, and an internal review committee at McMaster will review leading candidates.
The successful applicant receives a monetary prize of $5,000 CDN, and travel and accommodations are covered to enable the scientist to visit Hamilton, Ontario, Canada for a minimum of three days to receive the award. During that time, he or she will present a state-of-the-art lecture to researchers, and present a lecture of more general interest to the McMaster University community on a Global Health topic of broader scope. Opportunities for informal scientific exchanges between the scientist/scholar and faculty, postdoctoral fellows, graduate and undergraduate medical students will be emphasized during the visit.