Health Research Methods, Evidence, and Impact

Lehana Thabane

BSc (Lesotho), MSc (Sheffield), PhD (Western)

Professor and Associate Chair, Department of Health Research Methods, Evidence, and Impact

Director, Biostatistics Unit, Centre for Evaluation of Medicine

Senior Scientist, Population Health Research Institute (PHRI), Hamilton Health Sciences, McMaster University

Director of Biostatistics, System-Linked Research Unit, SLRU

905.522.1155 x 33720

St. Joseph's Healthcare Hamilton
3rd Floor, Martha Wing, Room H-325
50 Charlton Avenue East
Hamilton ON L8N 4A6

For Biostatistics Unit information click here

Project Assistant: Samantha Downey
905.522.1155 x 34905


Academic Interests

Dr. Thabane is a research methodologist with research interests in the development and application of statistical methods health research. He collaborates with researchers in cardiology, internal medicine, nephrology, HIV-AIDS, evidence-based medicine and health technology assessment. He provides statistical leadership in studies in various areas of population health research, clinical research, health services and outcomes research. As research methodologist, his research interests cover a wide spectrum of research areas including clinical trials, research ethics, and conjoint analysis of patient preferences for colorectal cancer screening. The applications of Bayesian hierarchical methods to model medical data, systematic reviews and meta-analysis of RCT's using both Bayesian and classical approaches.

Current HRM Graduate Students

Giulio DiDidato
Guowei Li
Thuva Vanniyasingam
Victoria Borg Debono
Sameer Parpia
Ji (Emmy) Cheng
Lawrence Mbuagbaw candidate in HRM - Clinical Epidemiology
Balpreet Guilhotra
Harsha Shanthanna
Arthur Lau
Reem Alkhalef

Recent HRM Graduate Students

Chenglin Ye, PhD in Biostatistics, currently Clinical Epidemiologist at Health Quality Ontario
Courtney Kennedy, PhD in Biostatistics, currently Research Methodologist, St. Peter’s Hospital, McMaster University
Junhui Ma, PhD in Biostatistics, currently Scientist at the Children’s Hospital of Eastern Ontario
Rong (Rachel) Chu, PhD in Biostatistics , currently Associate Biostatistics Manager Agensys, Inc
Robert Hopkins, PhD in Biostatistics, currently Biostatistician, PATH, McMaster University
Janice Pogue, PhD in Biostatistics, currently Statistical Manager, Population Health Institute
Kristian Thorlund, PhD in Biostatistics, currently Director at Redwood Outcomes, Stanford Prevention Research Center
Adewope Odueyungbo, PhD
George Ioannidis, PhD
Natasha Cohen candidate in HRM – Clinical Epidemiology
Sara Daisy Kosa
Maura Marcucci, candidate in HRM – Clinical Epidemiology
Victoria Borg Debono, MSc
Thuva Vanniyasingam, MSc
Shiyuan Zhang, MSc
Maura Marcucci,  MSc
Jeff Muir, MSc
Lisa-Ann Fraser, MSc
Juan Guzman, MSc
Luiz Garrido-Olivares, MSc

Selected Publications

  1. Ma J*, Raina P, Beyene J, Thabane L. Comparing the performance of different multiple imputation strategies for missing binary outcomes in cluster randomized trials: a simulation study. Open Access Medical Statistics 2012; 2:93-103.
  2. Brouwers MC, Thabane L, Moher D, Straus SE. The Comparative Effectiveness Research Paradigm: Implications for Systematic Reviews and Clinical Practice Guidelines. Journal of Clinical Oncology 2012; 30(34):4202-4207 PMID: 23071227.
  3. Mbuagbaw L*, Ye C*, Thabane L. Motivational interviewing for improving outcomes in youth living with HIV. Cochrane Database of Systematic Reviews 2012; 12; 9:CD009748 PMID: 22972147. Has been recommended as being of special significance in its field by the F1000 recommendations.
  4. Devereaux PJ, Alonso-Coelho P, Walsh M, Berwanger O, Wang CY, Garutti RI, Jacka MJ, Srinathan S, Biccard BM, Chow CK, Abraham V, Tiboni M, Petti S, Szczeklik W, Buse GL, Botto F, Guyatt G, Hells-Ansdell D, Sessler DI, Thorlund K27, Garg AX, Mrkobrada M, Thomas S, Rodeseth RN, Pearse RM, Thabane L, McQueen MJ, VanHelder T, Bhandari M, Bosh J, Kurz A, Polanczyk CA, Malaga G, Nagele P, Le Manach Y, Leuwer M, Yusuf S, and the Vision Investigators. Association between postoperative troponin levels and 30-day mortality among patients undergoing noncardiac surgery. Journal of the American Medical Association 2012; 307:2295.
  5. Chu R*, Thabane L, Stephen W, Guyatt G, Devereaux P, Thorlund K*. Assessment and Implication of Prognostic Imbalance in Randomized Controlled Trials with a Binary Outcome - A Simulation Study. PLoS ONE 2012; 7(5):e33677 PMID: 22629322
  6. Pogue J*, Thabane L, Devereaux P, Yusuf S. Designing and analyzing clinical trials with composite outcomes: Consideration of possible treatment differences between the individual outcomes. PLoS ONE 2012; 7(4):e34785 PMID: 22529934.
  7. Parpia S*, Julian JA, Thabane L, Lee AY, Rickles FR, Levine MN. Competing events in patients with malignant disease who are at risk for recurrent venous thromboembolism. Contemporary Clinical Trials 2011; 32(6):829-833 PMID 21777700.

    *Graduate student or mentee under my supervision

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