Health Research Methods, Evidence, and Impact

Marek Smieja

MD (Western), MSc (McMaster),
PhD (McMaster), FRCPC

Associate Professor, Department of Pathology and Molecular Medicine

Associate Member, Dept of Health Research Methods, Evidence, and Impact

Associate Member, Department of Medicine

Microbiologist & Infectious Diseases Physician, Hamilton Regional Laboratory Program

Member, Infections Research Group at St. Joseph’s Hospital

Founding Member, Ontario Working Group for the Rapid Diagnosis of Emerging Infections


St. Joseph's Healthcare
50 Charlton Ave. E.
L-424, St. Luke's Wing
Hamilton, ON
L8N 4A6

Administrative Assistant: Rita Taraschi
905.521.6143 x 3776

Academic Interests

My primary research interests are in the role of infections in respiratory and cardiac diseases. I lead the CIHR-sponsored Canadian HIV Vascular Study, a multi-centre cohort study assessing the relationships between HIV medications, metabolic abnormalities, and vascular disease among HIV-positive subjects.  I am co-chair of the Clinical Working Group of the OHTN Cohort Study, and chair a working group creating guidelines for cardiovascular risk assessment in HIV patients.

I am a member of the Canadian Pandemic Influenza Laboratory Preparedness Network, and co-principal investigator (with Dr. Astrid Petrich) of a CIHR-sponsored multi-laboratory study of rapid influenza molecular diagnostics.  I am involved in the design and improvement of pre-analytic, analytic, and post-analytic aspects of respiratory virus testing.

Selected Publications

  1. Lamontagne F, Garant M-P, Carvalho J-C, Lanthier L, Smieja M, Pilon D.  Pneumococcal Vaccination and Myocardial Infarct Risk.  CMAJ 2008: 179:773-7.
  2. Friis-Møller N, Smieja M, Klein D.  Antiretroviral Therapy as a Cardiovascular Disease Risk Factor - Fact or Fiction?  A review of clinical and surrogate outcome studies.  Current Opinion in HIV and AIDS 2008: 3(3):220-225. 
  3. Currier JS, Lundgren JE, Carr A, Klein D, Sabin CA, Sax PE, Schouten JT, Smieja M for Working Group 2.  Epidemiological Evidence for Cardiovascular Disease in HIV-Infected Patients and Relationship to Highly Active Antiretroviral Therapy. Circulation 2008: 118(2):e29-35.
  4. Daley P, Castriciano S, Chernesky M, Smieja M.  Comparison of Flocked and Rayon Swabs for Collection of Respiratory Epithelial Cells From Uninfected Volunteers and Symptomatic Patients. J Clin Microbiol 2006; 44:2265-7.
  5. Smieja M, Gnarpe J, Lonn E, Gnarpe H, Olsson G, Yi Q, Dzavik V, McQueen M, Yusuf S for the HOPE study investigators. Multiple infections and subsequent cardiovascular events in the Heart Outcomes Prevention Evaluation (HOPE) Study. Circulation 2003; 107(2):251-257.
  6. Smieja M, Mahony JB, Petrich A, Boman J, Chernesky M. Association of Circulating Chlamydia pneumoniae DNA with Cardiovascular Disease: A Systematic Review. BMC Infectious Diseases: 2002; 2:21.

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