Health Research Methods, Evidence, and Impact

Guillaume Pare

MD (Montreal), MSc (McGill), FRCPC

Associate Professor, Department of Pathology and Molecular Medicine

Joint Member, Dept of Health Research Methods, Evidence, and Impact

Canada Research Chair in Genetic and Molecular Epidemiology

Director, Genetic and Molecular Epidemiology Laboratory

Deputy Director, Clinical Research & Clinical Trials Laboratory, Hamilton Health Sciences Associate

Director, MacDATA Institute Co-Director, McMaster Genome Facility

Member: Population Genomics Program

McMaster University
3203 Michael DeGroote Centre for Learning & Discovery
(905) 527-4322 ext 40356 (research related inquiries only) or ext 44537 (clinical inquiries only, Lipid Clinic)
(905) 297-3789

Assistant: Sue McMillan

Currently accepting Graduate students
Currently accepting Post Doctoral Fellows

Education and Professional Standing

Research Fellow, Harvard Medical School, 2009
Medical Biochemist, University of Montreal, 2007
MSc, Human Genetics, McGill University, 2006
MD, University of Montreal, 2002


Academic Interests

My main research focus is Genetic and molecular epidemiology.  Briefly, I aim to identify  genetic determinants of complex disease such as hypertension, coronary artery disease, cerebrovascular disease and other types of chronic disease.  Another area of my research is the development and validation of novel biomarkers of disease. Genetic and molecular markers of disease are expected to lead to better understanding, prediction, and ultimately, prevention of diseases.

Selected Publication

  1. Dubuc G, Tremblay M, Paré G, Jacques H, Boulet L, Genest J, Bernier L, Seidah NG, Davignon J. A new method for measurement of total plasma PSCK9 - clinical applications. Journal of Lipid Research. In Press.
  2. Köttgen A, Glazer NL, Dehghan A, Hwang SH, Katz R, Li M, Yang Q, Gudnason V, Launer LJ, Harris TB, Smith AV, Arking DE, Astor BC, Boerwinkle E, Ehret GB, Ruczinski I, Scharpf RB, Chen YDI, deBoer IH, Haritunians T, Lumley T, Sarnak M, Siscovick D, Benjamin EJ, Levy D, Upadhyay A, Aulchenko YS, Hofman A, Rivadeneira F, Uitterlinden AG, vanDuijn CM, Chasman DI, Paré G, Ridker PM, Kao L, Witteman JC, Coresh J, Shlipak MG, Fox CS. Common Variants in the Gene Encoding Tamm-Horsfall Glycoprotein are Associated with Chronic Kidney Disease Risk. Nature Genetics. In Press.
  3. He C, Kraft P, Chen C, Buring JE, Paré G , Hankinson SE, Chanock S, Ridker PM, Hunter DJ, Chasman DI. Genome-wide association studies identify novel loci associated with age at menarche and age at natural menopause. Nature Genetics. In Press.
  4. Albert MA, Paré G, Morris A, Rose L, Buring J, Ridker PM, Zee RYL. Candidate Genetic Variants in the Fibrinogen, Methylenetetrahydrofolate Reductase and Intercellular Adhesion Molecule-1 Genes and Plasma levels of Fibrinogen, Homocysteine, and Intercellular Adhesion Molecule-1 Among Various Race/ethnic Groups: Data from the Women’s Genome Health Study. American Heart Journal. 157: 777-83, 2009
  5. Paré G, Chasman DI, Parker AN, Zee RYL, Mälarstig A, Seedorf U, Collins R, Watkins H, Hamsten A, Miletich JP, Ridker PM. Novel Association of CPS1, MUT, NOX4 and DPEP1 with Plasma Homocysteine in a Healthy Population: A Genome Wide Evaluation of 13,974 Participants in the Women’s Genome Health Study. Circulation: Cardiovascular Genetics. 2:142-150, 2009
  6. Danik JS, Paré G, Chasman DI, Zee RY, Kwiatkowski DJ, Parker AN, Miletich JP, Ridker PM. Multiple Novel Loci Identified in a Genome-Wide Association Study of Fibrinogen in 17,686 women: the Women’s Genome Health Study. Circulation: Cardiovascular Genetics. 2: 134-41, 2009
  7. Chasman DI, Paré G, Ridker PM. Population-based genomewide genetic analysis of common clinical chemistry analytes. Clinical Chemistry. 55:39-51, 2009
  8. Anand SS, Xie CC, Paré G , Montpetit A, Rangarajan S, McQueen M, Cordell H, Keavney B, Yusuf S, Hudson TJ, Engert J. Genetic Variants Associated with Myocardial Infarction risk factors in over 8,000 Individuals from Five Ethnic Groups: The INTERHEART Genetics Study. Circulation Cardiovascular Genetics. 2:16-25, 2009
  9. Ridker PM, Paré G, Parker AN, Zee RY, Miletich J, Chasman DI. Polymorphism in the CETP Gene Region, HDL Cholesterol, and Risk of Future Myocardial Infarction: Genomewide Analysis among 18,245 Initially Healthy Women from the Women’s Genome Health Study. Circulation Cardiovascular Genetics. 2:26-33, 2009
  10. Paré G, Chasman DI, Parker AN, Miletich J, Zee RY, Ridker PM. Novel Association of HK1 with Glycated Hemoglobin in a Non-Diabetic Population: A Genome Wide Evaluation of 14,618 Participants in the Women's Genome Health Study. PLoS Genetics. 4: e1000312, 2008

Search for citations for Dr. Pare on PubMed