McMaster University

 

McMaster University

 

 

research

Faculty

 

Jakob Magolan, PhD

 

Associate Professor,

Biochemistry and Biomedical Sciences

Boris Family Chair in Drug Discovery

Joint Member, Chemistry and Chemical Biology


MDCL - 2306
McMaster University

magolanj@mcmaster.ca

905-525-9140 ext. 22268

Research

- Pre-Clinical Drug Discovery and Development

- Organic Synthetic Methods

In collaboration with biologists and biochemists, we pursue the discovery and pre-clinical development of pharmaceutical leads in a variety of therapeutic areas including: antimicrobial, anti-pancreatic cancer, and anti-depression. We specialize in the chemical synthesis of lead compounds and their structural derivatives with a particular interest in natural product-based leads.

Our laboratory is also engaged in the development new strategies and methodologies for the efficient chemical synthesis. Our current areas of focus include: 1) new synthetic approaches to rare or unknown heterocyclic scaffolds; 2) expanding the versatility of simple inexpensive substrates like dimethylsulfoxide (DMSO) as synthetic building blocks; and 3) use of heterogeneous reagents to enhance procedural efficiency and minimize the environmental impact of organic synthesis.

 

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