Stem Cell and Cancer Research Institute
905-525-9140 ext. 20818
Visit Karun Singh's Homepage
Our primary research objective is to understand the pathological mechanisms of psychiatric disorders including schizophrenia and autism spectrum disorders.
Neuropsychiatric diseases including autism, schizophrenia and bipolar disorder are a major problem in our society as patients have few successful treatment options. One of the reasons is because scientists do not understand the pathogenic mechanisms of these diverse diseases, which makes discovering new drugs for treatment very difficult. Interestingly, neuropsychiatric illnesses tend to run in families, which means there is a genetic basis for these diseases. However only recently have we started to discover the genes that are responsible for increasing risk of disease. Furthermore, there is a lack of model organizms (eg. mouse models) that can faithfully recapitulate the genetic diversity and heterogeneity of these brain disorders.