Research Program Overview
Dr. Singh's research program is centred on the study of cancer stem cells. She recently identified an abnormal stem cell that may drive the formation of brain tumours. Using the cell surface protein CD133, Dr. Singh has characterized a rare subpopulation of brain tumour cells that exclusively generate a replica of the patient's tumour and exhibit self-renewal ability in vivo through serial retransplantation.
Her research program will focus on further molecular and genetic characterization of the brain tumour initiating cell (BTIC), and the molecular signalling pathways that are dysregulated in this cell to allow for brain tumorigenesis.
- Characterization of the Heterogeneity of Human BTICs
- Comparative Analysis of Normal vs Tumorigenic Human Neural Stem Cells expressing CD133
- Development of Therapeutic Targets for Brain Tumours
Publications & Achievements
- Singh SK et al. Cancer stem cells and CNS tumours. Neurosurgery Clinics of North America 2007: 18(1):pp31-38
- Singh SK et al. Identification of human brain tumor initiating cells. Nature 2004: 7015(432):pp396-401
- Singh SK et al. Cancer Stem Cells in Nervous System Tumours. Oncogene 2004: 23 pp7267-7273
- Singh SK et al. Cancer Stem cells. The Lancet 2004
- Singh SK et al. Isolation of a Cancer Stem Cell from Human Brain Tumours. Cancer Research 2003:63(18):pp521-528
Phone: 905-521-2100 x
Title: Administrative Assistant
Phone: 905-521-2100 x73673
Title: Clinical Research Associate