Research Program Overview
Main Research Areas: Investigations of normal and abnormal development of the extrinsic innervation of the gut
Specific Focus: My research is focused on determining how, during ontogeny, vagal and sacral nerves find their targets in the bowel and on examining whether developmental abnormalities of this innervation contribute to the pathogenesis of disorders of gastrointestinal motility.
Methodologies: These studies employ a variety of techniques in molecular biology, histology and tissue culture. Specific techniques include neuronal tracing, primary culture of tissue explants and quantitative image analysis.
- Title: Roles of guidance molecules in the innervation of the developing gut by extrinsic nerves
- Objective: To determine the role of axons guidance molecules in guiding extrinsic axons to the gut and targets within it.
- Gershon MD, Ratcliffe EM. (2004) Developmental Biology of the Enteric Nervous System: Pathogenesis of Hirschsprung’s Disease and other Congenital Dysmotilities. Semin Pediatr Surg 13(4): 224-35.
- Ratcliffe EM et al. (2006) Netrin/DCC- mediated attraction of vagal sensory axons to the fetal mouse gut. J Comp Neurol 498: 567-580.
- Ratcliffe EM et al. (2008) Laminin terminates the netrin/DCC mediated attraction of vagal sensory axons. Dev Neurobiol 68: 960-971.
Phone: 905-521-2100 x 73455
Title: Medical Secretary
Phone: 905-521-2100 x
Title: Research Assistant