Research Program Overview
Focused on the relationship between hemostatic system and diseases in children. Lab Research Program
includes Pediatric Thrombosis and Bronchopulmonary Dysplasia. Main research is the characterization of
antithrombin-heparin covalent complex (ATH): consists of structure/function of ATH as well as its potential to
be a pulmonary and systemic anticoagulant and a surface coating for catheters. Clinical Research Program,
mainly collaborative in nature, includes Pediatric Stroke (Dr. deVeber), Thrombosis in Pediatric Cancer Patients
(Dr. Athale), Thrombosis in Pediatric Cardiac Patients (Ms Gruenwald; Dr Brandao), and Neonatal Thrombosis
(Canadian Pediatric Thrombosis and Hemostasis Network).
Dr. Chan’s research laboratory is based at the Thrombosis and Atherosclerosis Research Institute (TaARI) in the David Braley Research Institute.
- Surface Mechanisms of Anticoagulant ATH Complex
- Study of Pathogenesis and Treatment of Pediatric Diseases Related to the Hemostatic System
- Changes in glycosylation of coagulation factors during childhood development
Publications & Achievements
- Creation and development of a novel anticoagulant ATH covalent complex, potentially for use as a
pulmonary/systemic anticoagulant or surface coating for catheters.
- Invention of a new clinical assay system to directly monitor thrombin generation in patient plasma/blood to
aid in assessing clinical conditions and treatments.
- Maintenance of a worldwide pediatric thrombophilia consultation service (1800NOCLOTS) to provide
information on pediatric thrombosis for physicians.
- Dr. Chan's research is frequently published in peer-reviewed publications in leading journals. A comprehensive list of publications is available on Research Gate.
Phone: 905-521-2100 x 73464
Title: Administrative Assistant
Phone: 905-905-521-2100 x40719
Title: Research Associate