McMaster University

McMaster University

Anthony K. C. Chan

Dr. Anthony K. C. Chan

Professor, Pediatrics

Chair,McMaster Children’s Hospital/Hamilton Health Sciences Foundation Pediatric Thrombosis and Hemostasis

Ph: 905-521-2100 x73464
Fx: 905-521-1703
Em: akchan@mcmaster.ca

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Research Theme

Hematology, thrombosis and cardiovascular disease

  • Primary Research: Thrombosis/Hemostasis
  • Secondary Research: Stroke

Key words

Thrombosis and hemostasis, Platelet function, Biochemistry, Protein/amino acid, Respiration

Research Program Overview

Focused on the relationship between hemostatic system and diseases in children. Lab Research Program includes Pediatric Thrombosis and Bronchopulmonary Dysplasia. Main research is the characterization of antithrombin-heparin covalent complex (ATH): consists of structure/function of ATH as well as its potential to be a pulmonary and systemic anticoagulant and a surface coating for catheters. Clinical Research Program, mainly collaborative in nature, includes Pediatric Stroke (Dr. deVeber), Thrombosis in Pediatric Cancer Patients (Dr. Athale), Thrombosis in Pediatric Cardiac Patients (Ms Gruenwald; Dr Brandao), and Neonatal Thrombosis (Canadian Pediatric Thrombosis and Hemostasis Network).

Dr. Chan’s research laboratory is based at the Thrombosis and Atherosclerosis Research Institute (TaARI) in the David Braley Research Institute.


Current Projects

  • Surface Mechanisms of Anticoagulant ATH Complex
  • Study of Pathogenesis and Treatment of Pediatric Diseases Related to the Hemostatic System
  • Changes in glycosylation of coagulation factors during childhood development

Publications & Achievements

  • Creation and development of a novel anticoagulant ATH covalent complex, potentially for use as a pulmonary/systemic anticoagulant or surface coating for catheters.
  • Invention of a new clinical assay system to directly monitor thrombin generation in patient plasma/blood to aid in assessing clinical conditions and treatments.
  • Maintenance of a worldwide pediatric thrombophilia consultation service (1800NOCLOTS) to provide information on pediatric thrombosis for physicians.
  • Dr. Chan's research is frequently published in peer-reviewed publications in leading journals. A comprehensive list of publications is available on Research Gate.

Secondary Contact

Wendy Armstrong
Phone: 905-521-2100 x 73464
Email: warmst@mcmaster.ca
Title: Administrative Assistant

Research Staff

Leslie Berry
Phone: 905-905-521-2100 x40719
Email: Leslie.Berry@taari.ca
Title: Research Associate

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